The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression
Open accessAbstract
Major alterations of the hypothalamic-pituitary-adrenocortical (HPA) system that can be reversed by successful antidepressant therapy are often seen in depressed patients. Persuasive evidence points to the involvement of a dysfunctional glucocorticoid receptor (GR) system in these changes. Support for this also comes from studies of transgenic mice that express an antisense RNA, complementary to the GR mRNA, and have numerous neuroendocrine characteristics of human depression as well as altered behaviour. Many of these neuroendocrine and behavioural characteristics of the transgenic mice can be reversed by antidepressants. A possible explanation for this is that the antidepressant-induced increase in GRs renders the HPA axis more sensitive to glucocorticoid feedback. This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs.
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“Previous studies have shown that pharmacological treatment can modulate cortisol levels independently of promoting remission of depressive symptoms. [8][9]][10]”
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Gut–brain axis: How the microbiome influences anxiety and depression
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Metadata
- Authors
- Barden, N.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Barden, Nicholas
- Venue
- Journal of Psychiatry and Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2004-05
- Volume
- 29
- Issue
- 3
- Pages
- 185-193
- ISSN
- 1180-4882 (ISSN-L)
- 1488-2434
- PMC
- PMC400688
- OpenAlex
- W20284704
- Cited by
- 416
- References
- 99
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 16 · 2023: 10 · 2022: 20 · 2021: 18 · 2020: 27 · 2019: 21 · 2018: 25 · 2017: 12 · 2016: 22 · 2015: 17 · 2014: 23 · 2013: 20 · 2012: 19
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- hypothalamic-pituitary-adrenal axis, depression, glucocorticoid receptor, antidepressant action, HPA axis dysregulation, glucocorticoid feedback, neuroendocrine dysfunction, antidepressant drug development
- MeSH terms
- Antidepressive Agents, Major Depressive Disorder, Humans, Hypothalamo-Hypophyseal System, Hypothalamus, Pituitary-Adrenal System, RNA, Antisense, Mutation, Missense
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