Lactoferrin, a key molecule in immune and inflammatory processes 1 This article is part of Special Issue entitled Lactoferrin and has undergone the Journal’s usual peer review process.

Legrand, Dominique

doi:10.1139/o11-056

Cited by 193Antimicrobial Peptides and ActivitiesImmune Response and InflammationInfant Nutrition and Health

Lactoferrin, a key molecule in immune and inflammatory processes 1 This article is part of Special Issue entitled Lactoferrin and has undergone the Journal’s usual peer review process.

Legrand, Dominique·2012·Biochemistry and Cell Biology

DOI 10.1139/o11-056

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Abstract

Lactoferrin (Lf) belongs to the family of antimicrobial molecules that constitute the principal defense line of nonvertebrate organisms. In human immunity, their roles are considerably extended, and actually exceed mere direct antimicrobial properties. As a result, Lf is involved in both innate and adaptive immunities where its modulating effects not only help the host fight against microbes but also protect the host against harmful effects of inflammation. Such beneficial effects have been noticed in studies using dietary Lf, without the experimenters always explaining the exact modes of action of Lf. Effects on mucosal and systemic immunities are indeed often observed, which make the roles of Lf tricky to decipher. It is now known that the immunomodulatory properties of Lf are due to its ability to interact with numerous cellular and molecular targets. At the cellular level, Lf modulates the migration, maturation, and functions of immune cells. At the molecular level, in addition to iron binding, interactions of Lf with a plethora of compounds, either soluble or cell-surface molecules, account for its modulatory properties. This paper reviews our current understanding of the mechanisms that explain the regulatory properties of Lf in immune and inflammatory processes.

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Lactoferrin, through binding to its cognate receptor, promotes the maturation, migration and cell proliferation of many immune cells including macrophages and monocytes, which impact the efficacy of host responses in the course of infections.
“In addition to its role in scavenging iron, lactoferrin, through binding to its cognate receptor, promotes the maturation, migration and cell proliferation of many immune cells including macrophages and monocytes which impact on the efficacy of host responses in the course of infections (Actor et al., 2009; Legrand, 2012; Lepanto et al., 2019).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Legrand, 2012

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Atsumi (2000) · doi:10.1002/1529-0131(200009)43:9

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Lactoferrin: a natural Glycoprotein involved in iron and inflammatory homeostasis
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The negatively charged regions of lactoferrin binding protein B, an adaptation against anti-microbial peptides
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Authors: Legrand, D.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Legrand, Dominique
ORCID: Legrand, Dominique
Venue: Biochemistry and Cell Biology
Publisher: Canadian Science Publishing
Published: 2012-06
Volume: 90
Issue: 3
Pages: 252-268
ISSN: 0829-8211 (ISSN-L)
1208-6002
DOI: 10.1139/o11-056
OpenAlex: W1949927726
Cited by: 193
References: 190
Citations by year: 2026: 4 · 2025: 11 · 2024: 13 · 2023: 7 · 2022: 28 · 2021: 15 · 2020: 15 · 2019: 16 · 2018: 14 · 2017: 10 · 2016: 15 · 2015: 11 · 2014: 18 · 2013: 14 · 2012: 2
FWCI: 2.08
Type: journal article
Language: en
Open access: closed
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Biochemistry and Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: lactoferrin, immunomodulation, inflammation, innate immunity, adaptive immunity, antimicrobial peptides, iron binding, leukocyte migration, immune cell maturation, mucosal immunity, host defense
MeSH terms: Animals, Humans, Immunity, Innate, Immunologic Factors, Lactoferrin, Neutrophils, Protein Binding, Signal Transduction, Inflammation Mediators, Adaptive Immunity

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