The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
VOLCANO PLOTS IN ANALYZING DIFFERENTIAL EXPRESSIONS WITH mRNA MICROARRAYS
Open accessAbstract
A volcano plot displays unstandardized signal (e.g. log-fold-change) against noise-adjusted/standardized signal (e.g. t-statistic or -log 10(p-value) from the t-test). We review the basic and interactive use of the volcano plot and its crucial role in understanding the regularized t-statistic. The joint filtering gene selection criterion based on regularized statistics has a curved discriminant line in the volcano plot, as compared to the two perpendicular lines for the "double filtering" criterion. This review attempts to provide a unifying framework for discussions on alternative measures of differential expression, improved methods for estimating variance, and visual display of a microarray analysis result. We also discuss the possibility of applying volcano plots to other fields beyond microarray.
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Disease progression in women with X-linked adrenoleukodystrophy is slow
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Metadata
- Authors
- LI, W.
- Venue
- Journal of Bioinformatics and Computational Biology
- Publisher
- World Scientific Pub Co Pte Lt
- Published
- 2012-10-18
- Volume
- 10
- Issue
- 06
- Pages
- 1231003
- ISSN
- 0219-7200 (ISSN-L)
- 1757-6334
- OpenAlex
- W1570820201
- Cited by
- 204
- References
- 16
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
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- LI, W. (2012). VOLCANO PLOTS IN ANALYZING DIFFERENTIAL EXPRESSIONS WITH mRNA MICROARRAYS. Journal of Bioinformatics and Computational Biology. https://doi.org/10.1142/s0219720012310038
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