The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity
Abstract
Mitochondria are essential metabolic hubs that dynamically adapt to physiological demands. More than 40 proteases residing in different compartments of mitochondria, termed mitoproteases, preserve mitochondrial proteostasis and are emerging as central regulators of mitochondrial plasticity. These multifaceted enzymes limit the accumulation of short-lived, regulatory proteins within mitochondria, modulate the activity of mitochondrial proteins by protein processing, and mediate the degradation of damaged proteins. Various signaling cascades coordinate the activity of mitoproteases to preserve mitochondrial homeostasis and ensure cell survival. Loss of mitoproteases severely impairs the functional integrity of mitochondria, is associated with aging, and causes pleiotropic diseases. Understanding the dual function of mitoproteases as regulatory and quality control enzymes will help unravel the role of mitochondrial plasticity in aging and disease.
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Cites
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BackgroundDuring autophagy mitochondria elongate, are spared from degradation and sustain cell viability
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The i -AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
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Self-citationMitonuclear communication in homeostasis and stress
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Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
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Cited by
Quality control of the mitochondrion
Ng, M. Y. W., Wai, T., & Simonsen, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.009 · Cited by 445
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control
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Self-citationMitophagy in the pathogenesis and management of disease
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Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration
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Metadata
- Authors
- Deshwal, S., Fiedler, K. U., & Langer, T.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2020-06-20
- Volume
- 89
- Issue
- 1
- Pages
- 501-528
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W3008239514
- Cited by
- 246
- References
- 17
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Deshwal, S., Fiedler, K. U., & Langer, T. (2020). Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-062917-012739
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