The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Role of Mammalian DNA Methyltransferases in Development
Abstract
DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the two DNMT families, DNMT3 and DNMT1, are responsible for methylation establishment and maintenance, respectively. Since their discovery, biochemical and structural studies have revealed the key mechanisms underlying how DNMTs catalyze de novo and maintenance DNA methylation. In particular, recent development of low-input genomic and epigenomic technologies has deepened our understanding of DNA methylation regulation in germ lines and early stage embryos. In this review, we first describe the methylation machinery including the DNMTs and their essential cofactors. We then discuss how DNMTs are recruited to or excluded from certain genomic elements. Lastly, we summarize recent understanding of the regulation of DNA methylation dynamics in mammalian germ lines and early embryos with a focus on both mice and humans.
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
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CpG islands and the regulation of transcription
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DNA methylation: roles in mammalian development
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EUKARYOTIC CYTOSINE METHYLTRANSFERASES
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Dynamics and function of DNA methylation in plants
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Conserved role of intragenic DNA methylation in regulating alternative promoters
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Self-citationDNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
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Paternal High-Fat Diet Affects Weight and DNA Methylation of Their Offspring
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Metadata
- Authors
- Chen, Z., & Zhang, Y.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2020-06-20
- Volume
- 89
- Issue
- 1
- Pages
- 135-158
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2993308551
- Cited by
- 371
- References
- 149
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
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