The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.
Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
Open accessAbstract
In recent years, tumor immunotherapy has made significant progress. However, tumor immunotherapy, particularly immune checkpoint inhibitors (e.g., PD-1/PD-L1 inhibitors), benefits only a tiny proportion of patients in solid cancers. The tumor microenvironment (TME) acts a significant role in tumor immunotherapy. Studies reported that tumor-associated macrophages (TAMs), as one of the main components of TME, seriously affected the therapeutic effect of PD-1/PD-L1 inhibitors. In this review, we analyzed TAMs from epigenetic and single-cell perspectives and introduced the role and mechanisms of TAMs in anti-programmed death protein 1(anti-PD-1) therapy. In addition, we summarized combination regimens that enhance the efficacy of tumor PD-1/PD-L1 inhibitors and elaborated on the role of the TAMs in different solid cancers. Eventually, the clinical value of TAMs by influencing the therapeutic effect of tumor PD-1/PD-L1 inhibitors was discussed. These above are beneficial to elucidate poor therapeutic effect of PD-1/PD-L1 inhibitors in solid tumors from the point of view of TAMs and explore the strategies to improve its objective remission rate of solid cancers.
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Self-citationMing, Z., Zhang, Y., Song, L., Chen, M., Lin, L., He, Y., Liu, W., Zhu, Y., Zhang, Y., & Zhang, G. (2024) · Advanced Science · doi:10.1002/advs.202309992 · Cited by 13
Zhou, E., Xing, Z., Wang, M., Lu, D., Hao, M., Tang, G., Li, S., Chen, Y., Zhang, W., Li, X., et al. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118198
Metadata
- Authors
- Zhang, H., Liu, L., Liu, J., Dang, P., Hu, S., Yuan, W., Sun, Z., Liu, Y., & Wang, C.
- Venue
- Molecular Cancer
- Published
- 2023-03-21
- Volume
- 22
- Issue
- 1
- Pages
- 58-58
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W4328048621
- Cited by
- 389
- References
- 219
- FWCI
- 34.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, H., Liu, L., Liu, J., Dang, P., Hu, S., Yuan, W., Sun, Z., Liu, Y., & Wang, C. (2023). Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers. Molecular Cancer. https://doi.org/10.1186/s12943-023-01725-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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