The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Functional Attachment of Soft Tissues to Bone: Development, Healing, and Tissue Engineering
Open accessAbstract
Connective tissues such as tendons or ligaments attach to bone across a multitissue interface with spatial gradients in composition, structure, and mechanical properties. These gradients minimize stress concentrations and mediate load transfer between the soft and hard tissues. Given the high incidence of tendon and ligament injuries and the lack of integrative solutions for their repair, interface regeneration remains a significant clinical challenge. This review begins with a description of the developmental processes and the resultant structure-function relationships that translate into the functional grading necessary for stress transfer between soft tissue and bone. It then discusses the interface healing response, with a focus on the influence of mechanical loading and the role of cell-cell interactions. The review continues with a description of current efforts in interface tissue engineering, highlighting key strategies for the regeneration of the soft tissue–to-bone interface, and concludes with a summary of challenges and future directions.
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Cites
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Cited by
Liu, Z., Meyers, M. A., Zhang, Z., & Ritchie, R. O. (2017) · Progress in Materials Science · doi:10.1016/j.pmatsci.2017.04.013 · Cited by 895
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
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The microstructure and micromechanics of the tendon–bone insertion
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Self-citation
Metadata
- Authors
- Lu, H. H., & Thomopoulos, S.
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2013-07-11
- Volume
- 15
- Issue
- 1
- Pages
- 201-226
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2156622891
- Cited by
- 447
- References
- 128
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Lu, H. H., & Thomopoulos, S. (2013). Functional Attachment of Soft Tissues to Bone: Development, Healing, and Tissue Engineering. Annual Review of Biomedical Engineering. https://doi.org/10.1146/annurev-bioeng-071910-124656
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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