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Potential of Nanofiber Matrix as Tissue-Engineering Scaffolds
Abstract
Tissue-engineering scaffolds should be analogous to native extracellular matrix (ECM) in terms of both chemical composition and physical structure. Polymeric nanofiber matrix is similar, with its nanoscaled nonwoven fibrous ECM proteins, and thus is a candidate ECM-mimetic material. Techniques such as electrospinning to produce polymeric nanofibers have stimulated researchers to explore the application of nanofiber matrix as a tissue-engineering scaffold. This review covers the preparation and modification of polymeric nanofiber matrix in the development of future tissue-engineering scaffolds. Major emphasis is also given to the development and applications of aligned, core shell-structured, or surface-functionalized polymer nanofibers. The potential application of polymer nanofibers extends far beyond tissue engineering. Owing to their high surface area, functionalized polymer nanofibers will find broad applications as drug delivery carriers, biosensors, and molecular filtration membranes in future.
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Citations
Cites
Rationalization of the effects of mutations on peptide andprotein aggregation rates
Chiti, F., Stefani, M., Taddei, N., Ramponi, G., & Dobson, C. M. (2003) · Nature · doi:10.1038/nature01891 · Cited by 1,072
Cited by
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Polymeric Scaffolds in Tissue Engineering Application: A Review
Dhandayuthapani, B., Yoshida, Y., Maekawa, T., & Kumar, D. S. (2011) · International Journal of Polymer Science · doi:10.1155/2011/290602 · Cited by 1,773
Nanotechnological strategies for engineering complex tissues
Dvir, T., Timko, B. P., Kohane, D. S., & Langer, R. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.246 · Cited by 1,367
Solution blow spinning: A new method to produce micro‐ and nanofibers from polymer solutions
Medeiros, E. S., Glenn, G. M., Klamczynski, A. P., Orts, W. J., & Mattoso, L. H. C. (2009) · Journal of Applied Polymer Science · doi:10.1002/app.30275 · Cited by 780
Electrospinning for tissue engineering scaffolds
Lannutti, J., Reneker, D., Ma, T., Tomasko, D., & Farson, D. (2007) · Materials Science and Engineering: C · doi:10.1016/j.msec.2006.05.019 · Cited by 693
Metadata
- Authors
- Ma, Z., Kotaki, M., Inai, R., & Ramakrishna, S.
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 2005-01
- Volume
- 11
- Issue
- 1-2
- Pages
- 101-109
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W2039497282
- Cited by
- 1,032
- References
- 1
- FWCI
- 24.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, Z., Kotaki, M., Inai, R., & Ramakrishna, S. (2005). Potential of Nanofiber Matrix as Tissue-Engineering Scaffolds. Tissue Engineering. https://doi.org/10.1089/ten.2005.11.101
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