Designing a novel vacuum aspiration system to decellularize large-size enthesis with preservation of physicochemical and biological properties
Open accessAbstract
BACKGROUND: Functional and rapid enthesis regeneration remains a challenge after arthroscopic rotator cuff (RC) repair. Tissue-engineering a large-size biomimetic scaffold may be an adjuvant strategy to improve this clinical dilemma. Herein, we developed an optimized protocol to decellularize large-size enthesis as scaffolds for augmenting RC tear. METHODS: A novel vacuum aspiration system (VAS) was set up, which can provide a negative pressure to suck out cellular substances from tissue blocks without using chemical detergents. Large-size enthesis tissue specimens were harvested from canine infraspinatus tendon (IT) insertion, and then decellularized with an optimized protocol [freeze-thaw processing followed by nuclease digestion and phosphate buffer saline (PBS) rinsing in the custom-designed VAS], or a conventional protocol (freeze-thaw processing followed by nuclease digestion and PBS rinsing), thus fabricating two kinds of acellular enthesis matrix (AEM), namely C-AEM and O-AEM. After that, the C-AEM and O-AEM were comparatively evaluated from the aspect of their physicochemical and biological properties. RESULTS: studies demonstrated that both C-AEM and O-AEM show no cytotoxicity and low immunogenicity, which could promote stem cells attachment and proliferation. Interestingly, O-AEM showed better region-specific inducibility on the interacted stem cell down osteogenic, chondrogenic and tenogenic lineages compared with C-AEM. Additionally, using a canine IT repair model, the injured enthesis patched with O-AEM showed a significant improvement compared with the injured enthesis patched with C-AEM or direct suture histologically. CONCLUSIONS: The proposed VAS may help us fabricate large-size AEM with good physicochemical and biological properties, and this AEM may have potential clinical applications in patching large/massive RC tear.
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Vacuum-assisted decellularization, employing negative pressure to expedite the process, can be utilized in conjunction with other techniques to enhance outcomes.
“Vacuum‐assisted decellularization, employing negative pressure to expedite the process, can be utilized in conjunction with other techniques to enhance outcomes.”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [65]
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Cites
Decellularization of tissues and organs
Gilbert, T. W., Sellaro, T. L., & Badylak, S. F. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.014 · Cited by 2,222 · see citing works
Galatz, L. M., Ball, C. M., Teefey, S. A., Middleton, W. D., & Yamaguchi, K. (2004) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200402000-00002 · Cited by 2,144 · see citing works
Benjamin, M., Toumi, H., Ralphs, J. R., Bydder, G. M., Best, T. M., & Milz, S. (2006) · Journal of Anatomy · doi:10.1111/j.1469-7580.2006.00540.x · Cited by 899 · see citing works
Mechanical properties of the human achilles tendon
Wren, T. A. L., Yerby, S. A., Beaupré, G. S., & Carter, D. R. P. (2001) · Clinical Biomechanics · doi:10.1016/s0268-0033(00)00089-9 · Cited by 466 · see citing works
Functional Attachment of Soft Tissues to Bone: Development, Healing, and Tissue Engineering
Lu, H. H., & Thomopoulos, S. (2013) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124656 · Cited by 449 · see citing works
Self-citationThe microstructure and micromechanics of the tendon–bone insertion
Rossetti, L., Kuntz, L. A., Kunold, E., Schock, J., Müller, K. W., Grabmayr, H., Stolberg-Stolberg, J., Pfeiffer, F., Sieber, S. A., Burgkart, R., et al. (2017) · Nature Materials · doi:10.1038/nmat4863 · Cited by 390 · see citing works
Cheng, C. W., Solorio, L. D., & Alsberg, E. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.12.012 · Cited by 358 · see citing works
Functional Grading of Mineral and Collagen in the Attachment of Tendon to Bone
Genin, G. M., Kent, A., Birman, V., Wopenka, B., Pasteris, J. D., Marquez, P. J., & Thomopoulos, S. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.05.043 · Cited by 332 · see citing works
Calcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells
Müller, P., Bulnheim, U., Diener, A., Lüthen, F., Teller, M., Klinkenberg, E., Neumann, H. G., Nebe, B. J., Liebold, A., Steinhoff, G., et al. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00103.x · Cited by 269 · see citing works
Engineering graded tissue interfaces
Phillips‐Cremins, J. E., Burns, K. L., Doux, J. M. L., Guldberg, R. E., & Garcı́a, A. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801988105 · Cited by 214 · see citing works
Extraction techniques for the decellularization of tissue engineered articular cartilage constructs
Elder, B. D., Eleswarapu, S. V., & Athanasiou, K. A. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.03.050 · Cited by 209 · see citing works
Spalazzi, J. P., Dagher, E., Doty, S. B., Guo, X., Rodeo, S. A., & Lu, H. H. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32073 · Cited by 192 · see citing works
Self-citationTendon‐to‐bone attachment: From development to maturity
Zelzer, E., Blitz, E., Killian, M. L., & Thomopoulos, S. (2014) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21056 · Cited by 179 · see citing works
Entheses: tendon and ligament attachment sites
BENJAMIN, M., & McGonagle, D. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2009.00906.x · Cited by 170 · see citing works
A sandwich model for engineering cartilage with acellular cartilage sheets and chondrocytes
Gong, Y., Xue, J. X., Zhang, W. J., Zhou, G. D., Liu, W., & Cao, Y. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.078 · Cited by 169 · see citing works
Evaluation of acellular and cellular nerve grafts in repair of rat peripheral nerve
Gulati, A. K. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.68.1.0117 · Cited by 168 · see citing works
Moriyama, Y., Watanabe, E., Kobayashi, K., Harano, H., Inui, E., & Takeda, K. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp8067624 · Cited by 155 · see citing works
Deprés-Tremblay, G., Chevrier, A., Snow, M., Hurtig, M., Rodeo, S. A., & Buschmann, M. D. (2016) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2016.06.009 · Cited by 153 · see citing works
Ide, J., Kikukawa, K., Hirose, J., Iyama, K.-I., Sakamoto, H., Fujimoto, T., & Mizuta, H. (2009) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2009.01.013 · Cited by 152 · see citing works
Freeze-Thaw Cycles Enhance Decellularization of Large Tendons
Burk, J., Erbe, I., Berner, D., Kacza, J., Kasper, C., Pfeiffer, B., Winter, K., & Brehm, W. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2012.0760 · Cited by 151 · see citing works
Augmentation of Tendon-to-Bone Healing
Ateşok, K., Fu, F. H., Wolf, M. R., Ochi, M., Jazrawi, L. M., Doral, M. N., Lubowitz, J. H., & Rodeo, S. A. (2014) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.m.00009 · Cited by 142 · see citing works
Abagnale, G., Sechi, A. S., Steger, M., Zhou, Q., Kuo, C., Aydın, G., Schalla, C., Müller‐Newen, G., Zenke, M., Costa, I. G., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.016 · Cited by 137 · see citing works
Kang, H., Peng, J. C., Lu, S., Liu, S., Zhang, L., Huang, J., Sui, X., Zhao, B., Wang, Y., Xu, W., et al. (2012) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1538 · Cited by 136 · see citing works
"Tissue Papers" from organ-specific decellularized extracellular matrices
Jakus, A. E., Laronda, M. M., Rashedi, A. S., Robinson, C. M., Lee, C., Jordan, S. W., Orwig, K. E., Woodruff, T. K., & Shah, R. N. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700992 · Cited by 133 · see citing works
Whitlock, P. W., Smith, T. L., Poehling, G. G., Shilt, J. S., & Dyke, M. E. V. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.05.029 · Cited by 126 · see citing works
Role of osteoblast–fibroblast interactions in the formation of the ligament‐to‐bone interface
Wang, I. E., Shan, J., Choi, R., Oh, S., Kepler, C. K., Chen, F. H., & Lu, H. H. (2007) · Journal of Orthopaedic Research® · doi:10.1002/jor.20475 · Cited by 123 · see citing works
Self-citationDerwin, K. A., Galatz, L. M., Ratcliffe, A., & Thomopoulos, S. (2018) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.18.00200 · Cited by 118 · see citing works
Liu, Q., Yu, Y., Reisdorf, R. L., Qi, J., Lu, C.-K., Berglund, L. J., Amadio, P. C., Moran, S. L., Steinmann, S. P., An, K., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.037 · Cited by 112 · see citing works
Preparation and characterization of decellularized tendon slices for tendon tissue engineering
Ning, L., Zhang, Y., Chen, X., Luo, J., Li, X., Yang, Z., & Qin, T. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34083 · Cited by 106 · see citing works
Modelling the mechanics of partially mineralized collagen fibrils, fibres and tissue
Liu, Y., Thomopoulos, S., Chen, C., Birman, V., Buehler, M. J., & Genin, G. M. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.0835 · Cited by 99 · see citing works
Self-citationPaxton, J. Z., Donnelly, K., Keatch, R. P., & Baar, K. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0105 · Cited by 95 · see citing works
Schneider, K. H., Enayati, M., Grasl, C., Walter, I., Budinský, L., Zebic, G., Kaun, C., Wagner, A., Kratochwill, K., Redl, H. R., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.045 · Cited by 74 · see citing works
Chen, C., Liu, F., Tang, Y., Qu, J., Cao, Y. B., Zheng, C., Chen, Y., Li, M., Zhao, C., Sun, L., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b20563 · Cited by 73 · see citing works
Self-citationSclerostin Antibody Treatment Enhances Rotator Cuff Tendon-to-Bone Healing in an Animal Model
Shah, S. A., Kormpakis, I., Havlioglu, N., Ominsky, M. S., Galatz, L. M., & Thomopoulos, S. (2017) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.16.01019 · Cited by 67 · see citing works
Sun, X.-H., Che, Y., Xiao-jie, T., Zhang, L., Feng, Y., Xu, A., Tong, L., Jia, H., & Zhang, X. (2008) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-008-9326-6 · Cited by 66 · see citing works
Xu, K., Kuntz, L. A., Foehr, P., Kuempel, K., Wagner, A. E., Tuebel, J., von Deimling, C., & Burgkart, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171577 · Cited by 62 · see citing works
Lü, H., Chen, C., Qu, J., Chen, H., Chen, Y., Zheng, C., Wang, Z., Xu, D., Zhou, J., Zhang, T., et al. (2016) · The American Journal of Sports Medicine · doi:10.1177/0363546516651863 · Cited by 59 · see citing works
Self-citationHu, J., Qu, J., Xu, D., Zhang, T., Qin, L., & Lü, H. (2013) · Journal of Orthopaedic Research® · doi:10.1002/jor.22505 · Cited by 59 · see citing works
Self-citationBlaudez, F., Ivanovski, S., Hamlet, S. M., & Vaquette, C. (2019) · Methods · doi:10.1016/j.ymeth.2019.08.002 · Cited by 59 · see citing works
Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces
Boys, A. J., McCorry, M. C., Rodeo, S. A., Bonassar, L. J., & Estroff, L. A. (2017) · MRS Communications · doi:10.1557/mrc.2017.91 · Cited by 55 · see citing works
Rotator cuff repair using cell sheets derived from human rotator cuff in a rat model
Harada, Y., Mifune, Y., Inui, A., Sakata, R., Muto, T., Takase, F., Ueda, Y., Kataoka, T., Kokubu, T., Kuroda, R., et al. (2016) · Journal of Orthopaedic Research® · doi:10.1002/jor.23289 · Cited by 51 · see citing works
Su, M., Zhang, Q., Zhu, Y., Wang, S., Lv, J., Sun, J., Qiu, P., Fan, S., Jin, K., Chen, L., et al. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900831 · Cited by 50 · see citing works
Czeisler, C. M., Short, A. R., Nelson, T., Gygli, P. E., Ortiz, C., Catacutan, F. P., Stocker, B., Cronin, J., Lannutti, J. J., Winter, J. O., et al. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24078 · Cited by 48 · see citing works
Dong, S., Ying, D., Duan, X., Xie, Z., Yu, Z., Zhu, C., Yang, B., & Sun, J. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90329 · Cited by 46 · see citing works
Decellularized Kidney Matrix for Perfused Bone Engineering
Burgkart, R., Tron, A., Prodinger, P. M., Culmes, M., Tuebel, J., van Griensven, M., Saldamli, B., & Schmitt, A. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0270 · Cited by 45 · see citing works
Xie, S., Zhou, Y., Tang, Y., Chen, C., Li, S., Zhao, C., Hu, J., & Lü, H. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24255 · Cited by 41 · see citing works
Self-citationNovel engineered tendon-fibrocartilage-bone composite with cyclic tension for rotator cuff repair
Liu, Q., Hatta, T., Qi, J., Liu, H., Thoreson, A. R., Amadio, P. C., Moran, S. L., Steinmann, S. P., Gingery, A., & Zhao, C. (2018) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2696 · Cited by 37 · see citing works
Spalazzi, J. P., Dagher, E., Doty, S. B., Guo, X., Rodeo, S. A., & Lu, H. H. (2006) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2006.259296 · Cited by 32 · see citing works
Self-citationZheng, C., Lü, H., Tang, Y., Wang, Z., Ma, H., Li, H., Chen, H., Chen, Y., & Chen, C. (2019) · The American Journal of Sports Medicine · doi:10.1177/0363546519849657 · Cited by 30 · see citing works
Self-citationPhysicochemical Decellularization of Composite Flexor Tendon–Bone Interface Grafts
Bronstein, J. A., Woon, C. Y.-L., Farnebo, S. J., Behn, A. W., Schmitt, T., Pham, H. M., Castillo, A. B., & Chang, J. (2013) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e318290f5fc · Cited by 28 · see citing works
Goriainov, V., Cook, R. B., Murray, J. W., Walker, J. C. F., Dunlop, D., Clare, A. T., & Oreffo, R. O. C. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00091 · Cited by 20 · see citing works
Guo, L.-Y., Qu, J., Zheng, C., Cao, Y. B., Zhang, T., Lü, H., & Hu, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144240 · Cited by 18 · see citing works
Self-citationLü, H., Chen, C., Wang, Z., Qu, J., Xu, D., Wu, T., Cao, Y. B., Zhou, J., Zheng, C., & Hu, J. (2015) · Spectrochimica Acta Part B Atomic Spectroscopy · doi:10.1016/j.sab.2015.06.001 · Cited by 14 · see citing works
Self-citationAssessment and treatment strategies for rotator cuff tears
Al-Hakim, W., Noorani, A. M., & Lambert, S. M. (2014) · Shoulder & Elbow · doi:10.1177/1758573214557143 · Cited by 13 · see citing works
Human acellular dermal matrix as a novel model of malignant epithelial cell invasion.
Bullard, K. M., Banda, M. J., Arbeit, J. M., Bergsland, E. K., & Young, D. M. (1997) · PubMed · Cited by 10 · see citing works
Czeisler, C. M., Short, A. R., Nelson, T., Gygli, P. E., Ortiz, C., Catacutan, F. P., Stocker, B., Cronin, J., Lannutti, J. J., Winter, J. O., et al. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24118 · Cited by 5 · see citing works
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Zhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680 · see citing works
Liu, J., Song, Q., Yin, W., Li, C., An, N., Le, Y., Wang, Q., Feng, Y., Hu, Y., & Wang, Y. (2025) · Exploration · doi:10.1002/exp.20230078 · Cited by 140 · see citing works
Functional acellular matrix for tissue repair
Wang, B., Qinglai, T., Yang, Q., Li, M., Zeng, S., Yang, X., Xiao, Z., Tong, X., Lei, L., & Li, S. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100530 · Cited by 111 · see citing works
Self-citationChen, C., Shi, Q., Li, M., Chen, Y., Zhang, T., Xu, Y., Liao, Y., Ding, S., Wang, Z., Li, X., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.12.021 · Cited by 53 · see citing works
Self-citationRecent Advances in Decellularized Matrix-Derived Materials for Bioink and 3D Bioprinting
Liu, H., Gong, Y., Zhang, K., Ke, S., Wang, Y., Wang, J., & Wang, H. (2023) · Gels · doi:10.3390/gels9030195 · Cited by 49 · see citing works
Milan, P. B., Masoumi, F., Biazar, E., Jalise, S. Z., & Mehrabi, A. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400322 · Cited by 41 · see citing works
Advanced strategies for constructing interfacial tissues of bone and tendon/ligament
Luo, W., Wang, Y., Han, Q., Wang, Z., Jiao, J., Gong, X., Liu, Y., Zhang, A., Zhang, H., Chen, H., et al. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221144714 · Cited by 30 · see citing works
Enthesis repair – State of play
Pugliese, E., Rossoni, A., & Zeugolis, D. I. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213740 · Cited by 18 · see citing works
Shang, P., Xiang, Y., Du, J., Chen, S., Cheng, B., Li, J., & Yuan, F. (2023) · ACS Applied Polymer Materials · doi:10.1021/acsapm.3c00791 · Cited by 17 · see citing works
Tavares, D. F., Mano, J. F., & Oliveira, M. B. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101735 · Cited by 11 · see citing works
Deng, Z., Zhu, W., Lu, B., Li, M., & Xu, D. (2022) · The American Journal of Sports Medicine · doi:10.1177/03635465221114412 · Cited by 11 · see citing works
Self-citationUnderstanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury
Rajalekshmi, R., & Agrawal, D. K. (2024) · Journal of Surgery and Research · doi:10.26502/jsr.10020363 · Cited by 8 · see citing works
Shi, Q., Chen, Y., Xu, Y., Chen, C., & Lü, H. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.01.004 · Cited by 7 · see citing works
Self-citationXu, Y., Wu, B., Zhang, Z., Mai, Y., Ling, Z., Bian, L., Chen, Y., & Wei, F. (2025) · ACS Nano · doi:10.1021/acsnano.5c16275 · Cited by 6 · see citing works
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Yuan, Y., Mao, Y., Sun, B., & Chen, C. (2025) · The American Journal of Sports Medicine · doi:10.1177/03635465241300138 · Cited by 5 · see citing works
Self-citationViet-Nhi, N.-K., Chen, Y., Đăng, L. H., Tseng, H., & Hung, S. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14030147 · Cited by 4 · see citing works
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- Authors
- Shi, Q., Chen, Y., Li, M., Zhang, T., Ding, S., Xu, Y., Hu, J., Chen, C., & Lu, H.
- Affiliations
- Central South University (CN)
- Corresponding author
- Chen, Can
- Venue
- Annals of Translational Medicine
- Publisher
- AME Publishing Company
- Published
- 2020-11
- Volume
- 8
- Issue
- 21
- Pages
- 1364-1364
- ISSN
- 2305-5839 (ISSN-L)
- 2305-5847
- PMC
- PMC7723548
- OpenAlex
- W3095163213
- Cited by
- 16
- References
- 57
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Annals of Translational Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (BL01B, 81902192, 2019M652809, 81730068)
- Central South University
- China Postdoctoral Science Foundation (2019M652809, 81730068, No. 2019M652809, 81902192)
- Fundamental Research Funds for the Central Universities
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Keywords
- rotator cuff tear, rotator cuff repair, infraspinatus tendon, freeze-thaw processing, nuclease digestion, stem cell differentiation, enthesis regeneration, tissue engineering scaffolds, canine model
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