The DOI matches its Crossref record; 198 of the 198 references it cites were found in a registry or an index.
Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis
Abstract
All multicellular animals express receptors for growth factors (GFs) and extracellular matrix (ECM) molecules. Integrin-type ECM receptors anchor cells to their surroundings and concomitantly activate intracellular signal transduction pathways. The same signaling mechanisms are regulated by GF receptors (GFRs). Recently, intensive research efforts have revealed novel mechanisms describing how the two receptor systems collaborate at many different levels. Integrins can directly bind to GFs and promote their activation. Adhesion receptors also organize signaling platforms and assist GFRs or even activate them via ligand-independent mechanisms. Furthermore, integrins can orchestrate endocytosis and recycling of GFRs. Here, we review the present knowledge about the interplay between integrins and GFRs and discuss recent ideas of how this collaboration may explain some previous controversies in integrin research.
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Self-citationExtracellular matrix, integrins, and growth factors as tailors of the stem cell niche
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Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
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Metadata
- Authors
- Ivaska, J., & Heino, J.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2011-11-10
- Volume
- 27
- Issue
- 1
- Pages
- 291-320
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2115276252
- Cited by
- 285
- References
- 198
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ivaska, J., & Heino, J. (2011). Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev-cellbio-092910-154017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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