The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Membrane Protein Insertion at the Endoplasmic Reticulum
Open accessAbstract
Integral membrane proteins of the cell surface and most intracellular compartments of eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and parallel pathways mediate membrane protein targeting to and insertion into this organelle. The classical cotranslational pathway, utilized by most membrane proteins, involves targeting by the signal recognition particle followed by insertion via the Sec61 translocon. A more specialized posttranslational pathway, employed by many tail-anchored membrane proteins, is composed of entirely different factors centered around a cytosolic ATPase termed TRC40 or Get3. Both of these pathways overcome the same biophysical challenges of ferrying hydrophobic cargo through an aqueous milieu, selectively delivering it to one among several intracellular membranes and asymmetrically integrating its transmembrane domain(s) into the lipid bilayer. Here, we review the conceptual and mechanistic themes underlying these core membrane protein insertion pathways, the complexities that challenge our understanding, and future directions to overcome these obstacles.
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Cites
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“The original and subsequent synthetic genetic array analysis of yeast genes (Battle et al. 2010; Costanzo et al. 2010; Jonikas et al. 2009; Schuldiner et al. 2005, 2008) clustered Get3 with five other genes whose products are the membrane proteins Get1 and Get2 and the cytosolic proteins Get4,…”
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Cited by
Circadian control of the secretory pathway maintains collagen homeostasis
(2020) · doi:10.1038/s41556-019-0441-z · Cited by 202
The Sec translocon mediated protein transport in prokaryotes and eukaryotes.
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Quality Control of Orphaned Proteins
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Self-citationStructure of the SecY channel during initiation of protein translocation
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Metadata
- Authors
- Shao, S., & Hegde, R. S.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2011-11-10
- Volume
- 27
- Issue
- 1
- Pages
- 25-56
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2151390847
- Cited by
- 289
- References
- 11
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Shao, S., & Hegde, R. S. (2011). Membrane Protein Insertion at the Endoplasmic Reticulum. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev-cellbio-092910-154125
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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