The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Rethinking m6A Readers, Writers, and Erasers
Open accessAbstract
In recent years, m 6 A has emerged as an abundant and dynamically regulated modification throughout the transcriptome. Recent technological advances have enabled the transcriptome-wide identification of m 6 A residues, which in turn has provided important insights into the biology and regulation of this pervasive regulatory mark. Also central to our current understanding of m 6 A are the discovery and characterization of m 6 A readers, writers, and erasers. Over the last few years, studies into the function of these proteins have led to important discoveries about the regulation and function of m 6 A. However, during this time our understanding of these proteins has also evolved considerably, sometimes leading to the reversal of early concepts regarding the reading, writing and erasing of m 6 A. In this review, we summarize recent advances in m 6 A research, and we highlight how these new findings have reshaped our understanding of how m 6 A is regulated in the transcriptome.
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Citations
Cites
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“…and stability, as well as the epigenetic effects of certain noncoding RNAs (Dominissini et al. 2012; Meyer et al. 2012, 2015; Patil et al. 2016; X. Wang et al. 2014, 2015; Xiao et al. 2016). m6A was first detected in poly(A) RNA fractions in 1974 (Desrosiers et al. 1974, Perry & Kelley 1974), but…”
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Cited by
Reading, writing and erasing mRNA methylation
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Interactions, localization, and phosphorylation of the m6A generating METTL3–METTL14–WTAP complex
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The molecular biology of FMRP: new insights into fragile X syndrome
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Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
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The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
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m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs
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SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication
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Metadata
- Authors
- Meyer, K. D., & Jaffrey, S. R.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2017-10-06
- Volume
- 33
- Issue
- 1
- Pages
- 319-342
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2608560932
- Cited by
- 1,150
- References
- 11
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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