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Polarized Protein Transport and Lumen Formation During Epithelial Tissue Morphogenesis
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One of the major challenges in biology is to explain how complex tissues and organs arise from the collective action of individual polarized cells. The best-studied model of this process is the cross talk between individual epithelial cells during their polarization to form the multicellular epithelial lumen during tissue morphogenesis. Multiple mechanisms of apical lumen formation have been proposed. Some epithelial lumens form from preexisting polarized epithelial structures. However, de novo lumen formation from nonpolarized cells has recently emerged as an important driver of epithelial tissue morphogenesis, especially during the formation of small epithelial tubule networks. In this review, we discuss the latest findings regarding the mechanisms and regulation of de novo lumen formation in vitro and in vivo.
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There are two main views of the mechanism mode of glandular lumen formation: cavitation and cell bundle hollowing.
“There are currently two main views of the mechanism mode of glandular lumen formation: cavitation (driven by cell death of inner cells) and cell bundle hollowing (driven by epithelial polarity without cell death).[11]”
From Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids (2022) · cites this paper as [11]
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Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila
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CD13 orients the apical-basal polarity axis necessary for lumen formation
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Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42
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Blastocoel morphogenesis: A biophysics perspective
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Stay hydrated: basolateral fluids shaping tissues
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Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation
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The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation
Skouloudaki, K., Papadopoulos, D. K., Tomančák, P., & Knust, E. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007852 · Cited by 15
Understanding post-mitotic roles of the midbody during cell differentiation and polarization
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Self-citationMembrane trafficking in morphogenesis and planar polarity
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Computational approaches for simulating luminogenesis
Fuji, K., Tanida, S., Sano, M., Nonomura, M., Riveline, D., Honda, H., & Hiraiwa, T. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.05.021 · Cited by 10
Shaping the thyroid: From peninsula to de novo lumen formation
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Zhang, R., Deng, H., Lin, Y., Wang, X., He, B., Dai, W., Zhang, H., Zheng, Y., Zhang, Q., & Wang, X. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.10.004 · Cited by 9
Membrane Lipids in Epithelial Polarity: Sorting out the PIPs
Gwilt, K. B., & Thiagarajah, J. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.893960 · Cited by 11
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The dynamics of tubulogenesis in development and disease
Romero, A. D. B., Walker, B. L., Krneta‐Stankic, V., Gerner-Mauro, K. N., Youmans, L., & Miller, R. K. (2025) · Development · doi:10.1242/dev.202820 · Cited by 9
Physics of notochord tube expansion in ascidians
Shi, W., Duclut, C., Xu, Y., Ma, Y., Qiao, J., Lin, B., Yang, D., Prost, J., & Dong, B. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2419960122 · Cited by 8
ELMOD3-Rab1A-Flotillin2 cascade regulates lumen formation via vesicle trafficking in Ciona notochord
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Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids
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Intercellular fluid dynamics in tissue morphogenesis
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Polarized transport of membrane and secreted proteins during lumen morphogenesis
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Coexisting mechanisms of luminogenesis in pancreatic cancer-derived organoids
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Bone grafting in total hip replacement. Preliminary results with MRI.
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Actin polymerization drives lumen formation in a human epiblast modelPreprint
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Using Optogenetics to Investigate the Shared Mechanisms of Apical-Basal Polarity and Mitosis
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Hepatoblast Iterative Apicobasal Polarization is Regulated by Extracellular Matrix RemodelingPreprint
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Principles of Epithelial Transport
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Bulk delivery of a preassembled apical surface initiates epithelial lumen formation
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Stay hydrated: Basolateral fluids shaping tissuesPreprint
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Specific Mitotic Events Drive Cytoskeletal Remodeling Required for Left-Right Organizer DevelopmentPreprint
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GCK-4 regulates apical actin organization and lumen formation in the C. elegans intestinePreprint
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aPKC exclusion from the apical cortex in enteroblasts maintains stem cell homeostasis in Drosophila
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Metadata
- Authors
- Blasky, A. J., Mangan, A., & Prekeris, R.
- Affiliations
- University of Colorado Anschutz (US)
- ORCID
- Prekeris, Rytis
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2015-11-13
- Volume
- 31
- Issue
- 1
- Pages
- 575-591
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- PMC
- PMC4927002
- OpenAlex
- W2126964995
- Cited by
- 78
- References
- 72
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 3 · 2017: 11 · 2016: 6
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM08730, T32GM008730)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064380)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- lumen formation, cell polarity, apical-basal polarity, intercellular communication
- MeSH terms
- Animals, Epithelial Cells, Humans, Morphogenesis, Cell Polarity, Protein Transport
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