The DOI matches its Crossref record; 257 of the 257 references it cites were found in a registry or an index.
Placenta: The Forgotten Organ
Abstract
The placenta sits at the interface between the maternal and fetal vascular beds where it mediates nutrient and waste exchange to enable in utero existence. Placental cells (trophoblasts) accomplish this via invading and remodeling the uterine vasculature. Amazingly, despite being of fetal origin, trophoblasts do not trigger a significant maternal immune response. Additionally, they maintain a highly reliable hemostasis in this extremely vascular interface. Decades of research into how the placenta differentiates itself from embryonic tissues to accomplish these and other feats have revealed a previously unappreciated level of complexity with respect to the placenta's cellular composition. Additionally, novel insights with respect to roles played by the placenta in guiding fetal development and metabolism have sparked a renewed interest in understanding the interrelationship between fetal and placental well-being. Here, we present an overview of emerging research in placental biology that highlights these themes and the importance of the placenta to fetal and adult health.
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“Little evidence exists on the neglected role of the placental characteristics and the prediction of these complications [106].”
Citations
Cites
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Cited by
Sorted by citations
Single-cell reconstruction of the early maternal–fetal interface in humans
Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358
Pathophysiology from preconception, during pregnancy, and beyond.
Hivert, M.-F., Backman, H., Benhalima, K., Catalano, P., Desoye, G., Immanuel, J., McKinlay, C. J. D., Meek, C. L., Nolan, C. J., Ram, U., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00827-4 · Cited by 186
Ashary, N., Bhide, A., Chakraborty, P., Colaco, S., Mishra, A., Chhabria, K., Jolly, M. K., & Modi, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00783 · Cited by 121
Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals
Padmanabhan, V., Song, W., & Puttabyatappa, M. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa035 · Cited by 103
Recent advances in liver engineering with decellularized scaffold
Dai, Q., Jiang, W., Huang, F., Song, F., Zhang, J., & Zhao, H. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.831477 · Cited by 57
Jost, E., Kosian, P., Jimenez Cruz, J., Albarqouni, S., Gembruch, U., Strizek, B., & Recker, F. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216833 · Cited by 44
“Little evidence exists on the neglected role of the placental characteristics and the prediction of these complications [106].”
BackgroundEndocrine-Disrupting Chemicals in Human Fetal Growth
Street, M. E., & Bernasconi, S. (2020) · Prime Archives in Molecular Biology · doi:10.37247/pamb.1.2020.42 · Cited by 35
Ishikawa, N., Watanabe, Y., Maeda, Y., Yoshida, T., Kimura, N., Abe, H., Sakamaki, A., Kamimura, H., Yokoo, T., Kamimura, K., et al. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.01.017 · Cited by 6
Metadata
- Authors
- Maltepe, E., & Fisher, S. J.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2015-11-13
- Volume
- 31
- Issue
- 1
- Pages
- 523-552
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2101822059
- Semantic Scholar
- 4e22a122e4d9dbec6ecc8419350745b2d4db94da
- Cited by
- 592
- References
- 257
- Citations by year
- 2026: 82 · 2025: 87 · 2024: 76 · 2023: 90 · 2022: 80 · 2021: 66 · 2020: 37 · 2019: 23 · 2018: 21 · 2017: 22 · 2016: 7 · 2015: 1
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD055764, R01HD072455)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- placenta, trophoblast, maternal-fetal interface, maternal-fetal immune tolerance, hemostasis, placental differentiation, fetal development, fetal metabolism, placental biology
- MeSH terms
- Animals, Biological Transport, Female, Humans, Placenta, Pregnancy, Trophoblasts, Fetal Development
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