Placenta: The Forgotten Organ

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251

The Evolution of Parental Care

Clutton‐Brock, T. H. (2019) · Princeton University Press eBooks · doi:10.2307/j.ctvs32ssj · Cited by 3,143

The Evolution of Parental Care

Clutton‐Brock, T. H. (1991) · Princeton University Press eBooks · doi:10.1515/9780691206981 · Cited by 2,785

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601

The Pathology of the Human Placenta

Benirschke, K., & Driscoll, S. G. (1967) · Springer eBooks · doi:10.1007/978-1-4612-9809-0 · Cited by 2,253

Preterm labor: One syndrome, many causes

Romero, R., Dey, S. K., & Fisher, S. J. (2014) · Science · doi:10.1126/science.1251816 · Cited by 1,984

Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis

Mi, S., Lee, X., Li, X., Veldman, G. M., Finnerty, H. F., Collins‐Racie, L. A., LaVallie, E. R., Tang, X.-Y., Edouard, P., Howes, S., et al. (2000) · Nature · doi:10.1038/35001608 · Cited by 1,711

The “Great Obstetrical Syndromes” are associated with disorders of deep placentation

Brosens, I., Pijnenborg, R., Vercruysse, L., & Romero, R. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.08.009 · Cited by 1,568

HIF-1: upstream and downstream of cancer metabolism

Semenza, G. L. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.10.009 · Cited by 1,431

Mechanisms of implantation: strategies for successful pregnancy

Cha, J., Sun, X., & Dey, S. K. (2012) · Nature Medicine · doi:10.1038/nm.3012 · Cited by 1,391

Promotion of Trophoblast Stem Cell Proliferation by FGF4

Tanaka, S., Kunath, T., Hadjantonakis, A., Nagy, A., & Rossant, J. (1998) · Science · doi:10.1126/science.282.5396.2072 · Cited by 1,370

Placental development: Lessons from mouse mutants

Rossant, J., & Cross, J. C. (2001) · Nature Reviews Genetics · doi:10.1038/35080570 · Cited by 1,299

The developmental role of serotonin: news from mouse molecular genetics

Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297

The Uterine Spiral Arteries In Human Pregnancy: Facts and Controversies

Pijnenborg, R., Vercruysse, L., & HANSSENS, M. C. A. J. A. (2006) · Placenta · doi:10.1016/j.placenta.2005.12.006 · Cited by 1,229

Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation

Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R., & Rossant, J. (2005) · Cell · doi:10.1016/j.cell.2005.08.040 · Cited by 1,192

Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

Strumpf, D., Mao, C., Yamanaka, Y., Ralston, A., Chawengsaksophak, K., Beck, F., & Rossant, J. (2005) · Development · doi:10.1242/dev.01801 · Cited by 1,124

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

Nishioka, N., Inoue, K., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson, R. O., Ogonuki, N., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.003 · Cited by 1,120

Serine and glycine metabolism in cancer

Amelio, I., Cutruzzolà, F., Antonov, A., Agostini, M., & Melino, G. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.004 · Cited by 1,080

The Hyperglycemia and Adverse Pregnancy Outcome Study

Catalano, P. M., McIntyre, H. D., Cruickshank, J. K., McCance, D. R., Dyer, A. R., Metzger, B. E., Lowe, L. P., Trimble, E. R., Coustan, D. R., Hadden, D. R., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1790 · Cited by 954

The role of the spiral arteries in the pathogenesis of pre-eclampsia.

Brosens, I. A., Robertson, W. B., & Dixon, H. G. (1970) · PubMed · Cited by 953

Regulation of Human Placental Development by Oxygen Tension

Genbačev, O., Zhou, Y., Ludlow, J. W., & Fisher, S. J. (1997) · Science · doi:10.1126/science.277.5332.1669 · Cited by 937

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (2009) · Physiology · doi:10.1152/physiol.00045.2008 · Cited by 926

Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface

Red‐Horse, K., Zhou, Y., Genbačev, O., Prakobphol, A., Foulk, R. A., McMaster, M., & Fisher, S. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422991 · Cited by 796

Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy

Pijnenborg, R., Bland, J. M., Robertson, W. B., & Brosens, I. A. (1983) · Placenta · doi:10.1016/s0143-4004(83)80043-5 · Cited by 733

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

Mabjeesh, N. J., Escuin, D., LaVallee, T. M., Pribluda, V. S., Swartz, G. M., Johnson, M. S., Willard, M. T., Zhong, H., Simons, J. W., & Giannakakou, P. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00077-1 · Cited by 730

An Envelope Glycoprotein of the Human Endogenous Retrovirus HERV-W Is Expressed in the Human Placenta and Fuses Cells Expressing the Type D Mammalian Retrovirus Receptor

Blond, J.-L., Lavillette, D., Cheynet, V., Bouton, O., Oriol, G., Chapel‐Fernandes, S., Mandrand, B., Mallet, F., & Cosset, F. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.3321-3329.2000 · Cited by 714

Cyclin E Ablation in the Mouse

Geng, Y., Yu, Q., Sicińska, E., Das, M., Schneider, J. E., Bhattacharya, S., Rideout, W. M., Bronson, R. T., Gardner, H., & Siciński, P. (2003) · Cell · doi:10.1016/s0092-8674(03)00645-7 · Cited by 663

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

Rossant, J., & Tam, P. (2009) · Development · doi:10.1242/dev.017178 · Cited by 647

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

Caniggia, I., Mostachfi, H., Winter, J., Gassmann, M., Lye, S. J., Kuliszewski, M., & Post, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8316 · Cited by 644

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome

Zhou, Y., McMaster, M., Woo, K., Janatpour, M. J., Perry, J., Kärpänen, T., Alitalo, K. K., Damsky, C. H., & Fisher, S. J. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62567-9 · Cited by 643

Eomesodermin is required for mouse trophoblast development and mesoderm formation

Russ, A., Wattler, S., Colledge, W. H., Aparicio, S. A. J. R., Carlton, M. B. L., Pearce, J., Barton, S. C., Surani, M. A., Ryan, K., Nehls, M. C., et al. (2000) · Nature · doi:10.1038/35003601 · Cited by 633

A transient placental source of serotonin for the fetal forebrain

Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., Blakely, R. D., Deneris, E. S., & Levitt, P. (2011) · Nature · doi:10.1038/nature09972 · Cited by 608

Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.

Genbačev, O., Joslin, R. J., Damsky, C. H., Polliotti, B., & Fisher, S. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118447 · Cited by 577

Viviparity: The Maternal-Fetal Relationship in Fishes

Wourms, J. P. (1981) · American Zoologist · doi:10.1093/icb/21.2.473 · Cited by 572

Extracorporeal Membrane Oxygenation (ECMO) Cardiopulmonary Support in Infancy

Bartlett, R. H., Gazzaniga, A. B., Jefferies, M. R., Huxtable, R. F., Haiduc, N. J., & Fong, S. W. (1979) · Journal of ExtraCorporeal Technology · doi:10.1051/ject/197911126 · Cited by 518

Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos

Nishioka, N., Yamamoto, S., Kiyonari, H., Sato, H., Sawada, A., Ota, M., Nakao, K., & Sasaki, H. (2007) · Mechanisms of Development · doi:10.1016/j.mod.2007.11.002 · Cited by 513

Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions?

Villar, J., Carroli, G., WOJDYLA, D. M., Abalos, E. J., Giordano, D., Ba’aqeel, H., Farnot, U., Bergsjø, P., Bakketeig, L. S., Lumbiganon, P., et al. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.10.813 · Cited by 464

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

Hirate, Y., Hirahara, S., Inoue, K., Suzuki, A., Alarcón, V. B., Akimoto, K., Hirai, T., Hara, T., Adachi, M., Chida, K., et al. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.014 · Cited by 447

Transposon-mediated rewiring of gene regulatory networks contributed to the evolution of pregnancy in mammals

Lynch, V. J., Leclerc, R. D., May, G. E., & Wagner, G. P. (2011) · Nature Genetics · doi:10.1038/ng.917 · Cited by 434

Endogenous retroviruses function as species-specific enhancer elements in the placenta

Chuong, E. B., Rumi, M. A. K., Soares, M. J., & Baker, J. C. (2013) · Nature Genetics · doi:10.1038/ng.2553 · Cited by 429

A genetic mechanism for Tibetan high-altitude adaptation

Lorenzo, F., Huff, C. D., Myllymäki, M., Olenchock, B. A., Swierczek, S. I., Tashi, T., Gordeuk, V. R., Wuren, T., Ge, R., McClain, D. A., et al. (2014) · Nature Genetics · doi:10.1038/ng.3067 · Cited by 429

The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta

Anson‐Cartwright, L., Dawson, K. M., Holmyard, D., Fisher, S. J., Lazzarini, R. A., & Cross, J. C. (2000) · Nature Genetics · doi:10.1038/77076 · Cited by 418

The expectant brain: adapting for motherhood

Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407

Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2

Takeda, K., Ho, V. C., Takeda, H., Duan, L.-J., Nagy, A., & Fong, G.-H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00425-06 · Cited by 401

Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta

Simmons, D. G., Fortier, A., & Cross, J. C. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.009 · Cited by 399

Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

Griffin, L. D., Gong, W., Verot, L., & Mellon, S. H. (2004) · Nature Medicine · doi:10.1038/nm1073 · Cited by 395

Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes

Kim, Y. M., Bujold, E., Chaiworapongsa, T., Gómez, R., Yoon, B. H., Thaler, H. T., Rotmensch, S., & Romero, R. J. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00838-x · Cited by 387

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegansPreprint

Lum, D. H., Kuwabara, P. E., Zarkower, D. A., & Spence, A. M. (2000) · Genes & Development · doi:10.1101/gad.853700 · Cited by 385

Pathology of the Human Placenta

Benirschke, K., & Kaufmann, P. (1995) · Springer eBooks · doi:10.1007/978-1-4757-4196-4 · Cited by 384

Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5

Ng, R. K., Dean, W., Dawson, C., Lucifero, D., Madeja, Z. E., Reik, W., & Hemberger, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1786 · Cited by 374

Regulation of vascular growth and function in the human placenta

Burton, G. J., Jones, D. S., & Jauniaux, E. R. M. (2009) · Reproduction · doi:10.1530/rep-09-0092 · Cited by 369

The hyperlipidemia of pregnancy in normal and complicated pregnancies

Potter, J. M., & Nestel, P. J. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90469-1 · Cited by 368

Autism Spectrum Disorders in Extremely Preterm Children

Johnson, S., Hollis, C., Kochhar, P., Hennessy, E., Wolke, D., & Marlow, N. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.10.041 · Cited by 366

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

Gnarra, J. R., Ward, J. M., Porter, F. D., WAGNER, J. R., Devor, D. E., Grinberg, A., Emmert‐Buck, M. R., Westphal, H., Klausner, R. D., & Linehan, W. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9102 · Cited by 366

Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene

Dupressoír, A., Vernochet, C., Bawa, O., Harper, F., Pierron, G., Opolon, P., & Heidmann, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902925106 · Cited by 364

Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1

Nevo, O., Soleymanlou, N., Wu, Y., Xu, J., Kingdom, J. C., Many, A., Zamudio, S., & Caniggia, I. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00794.2005 · Cited by 361

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse

Niakan, K. K., & Eggan, K. C. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.12.008 · Cited by 361

Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth

Edgar, B. A., Zielke, N., & Gutiérrez, C. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3756 · Cited by 360

The effect of high altitude and other risk factors on birthweight: independent or interactive effects?

Jensen, G. M., & MOORE, L. G. (1997) · American Journal of Public Health · doi:10.2105/ajph.87.6.1003 · Cited by 355

The pattern of interstitial trophoblasticinvasion of the myometrium in early human pregnancy

Pijnenborg, R., Bland, J. M., Robertson, W. B., Dixon, G., & Brosens, I. A. (1981) · Placenta · doi:10.1016/s0143-4004(81)80027-6 · Cited by 354

Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling

Kasahara, A., Cipolat, S., Chen, Y., Dorn, G. W., & Scorrano, L. (2013) · Science · doi:10.1126/science.1241359 · Cited by 354

Doppler ultralsound of the uterine arteries: the importance of bilateral notching in the prediction of pre‐eclampsia, placental abruption or delivery of a small‐for‐gestational‐age baby

Harrington, K., Cooper, D., Lees, C. C., Hecher, K., & Campbell, S. C. (1996) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1996.07030182.x · Cited by 351

Pregnancy: a stress test for life

Williams, D. J. (2003) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-200312000-00002 · Cited by 346

Evolution of the mammalian placenta revealed by phylogenetic analysis

Wildman, D. E., Chen, C., Erez, O., Grossman, L. I., Goodman, M., & Romero, R. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511344103 · Cited by 341

Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury

HE, J., EVANS, C., Hoffman, S. D., Oyesiku, N. M., & Stein, D. G. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.008 · Cited by 332

Trophectoderm Lineage Determination in Cattle

Berg, D. K., Smith, C. S., Pearton, D. J., Wells, D. N., Broadhurst, R. B., Donnison, M. J., & Pfeffer, P. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.003 · Cited by 323

Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation.

Jansson, T., Wennergren, M., & Illsley, N. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263141 · Cited by 320

Development and function of trophoblast giant cells in the rodent placenta

Hu, D., & Cross, J. C. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082768dh · Cited by 319

The placenta: transcriptional, epigenetic, and physiological integration during development

Maltepe, E., Bakardjiev, A. I., & Fisher, S. J. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41211 · Cited by 315

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling

Knöfler, M., & Pollheimer, J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00190 · Cited by 314

Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain

Bonnin, A., & Levitt, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.005 · Cited by 311

Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum

Hubel, C. A., McLaughlin, M. K., Evans, R. G., Hauth, B. A., Sims, C. J., & Roberts, J. M. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70336-8 · Cited by 301

Progesterone exerts neuroprotective effects after brain injury

Stein, D. G. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.012 · Cited by 294

Defective trophoblast function in mice with a targeted mutation of Ets2Preprint

Yamamoto, H., Flannery, M. L., Kupriyanov, S., Pearce, J., McKercher, S. R., Henkel, G. W., Maki, R. A., Werb, Z., & Oshima, R. G. (1998) · Genes & Development · doi:10.1101/gad.12.9.1315 · Cited by 292

Oxygen, the Janus gas; its effects on human placental development and function

Burton, G. J. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00978.x · Cited by 290

Intrauterine Growth Restriction, Preeclampsia, and Intrauterine Mortality at High Altitude in Bolivia

Keyes, L. E., Armaza, F. J., Niermeyer, S., Vargas, E., Young, D. A., & Moore, L. G. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000069846.64389.dc · Cited by 285

Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes

Kim, Y. M., Chaiworapongsa, T., Gómez, R., Bujold, E., Yoon, B. H., Rotmensch, S., Thaler, H. T., & Romero, R. J. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.127720 · Cited by 280

A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy

Alavi, M. V., Bette, S. J., Schimpf, S., Schuettauf, F., Schraermeyer, U., Wehrl, H. F., Rüttiger, L., Beck, S. C., Tonagel, F., Pichler, B. J., et al. (2006) · Brain · doi:10.1093/brain/awm005 · Cited by 278

Methods of assessing extinction risk in marine fishes

Dulvy, N. K., Ellis, J. R., Goodwin, N. B., Grant, A., Reynolds, J. D., & Jennings, S. (2004) · Fish and Fisheries · doi:10.1111/j.1467-2679.2004.00158.x · Cited by 278

Placental programming of chronic diseases, cancer and lifespan: A review

Barker, D. J. P., & Thornburg, K. L. (2013) · Placenta · doi:10.1016/j.placenta.2013.07.063 · Cited by 276

The evolution of parental care in fishes, with reference to Darwin's rule of male sexual selection

Baylis, J. R. (1981) · Environmental Biology of Fishes · doi:10.1007/bf00002788 · Cited by 268

Evaluation of Cell Viability and Functionality in Vessel-like Bioprintable Cell-Laden Tubular Channels

Yu, Y., Zhang, Y., Martin, J. A., & Ozbolat, I. T. (2013) · Journal of Biomechanical Engineering · doi:10.1115/1.4024575 · Cited by 268

Evolutionary transitions among egg–laying, live–bearing and maternal inputs in sharks and rays

Dulvy, N. K., & Reynolds, J. D. (1997) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1997.0181 · Cited by 266

Regulation of Placental Angiogenesis

Chen, D., & Zheng, J. J. (2013) · Microcirculation · doi:10.1111/micc.12093 · Cited by 256

Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy

Lynch, V. J., Nnamani, M. C., Kapusta, A., Brayer, K. J., Plaza, S. L., Mazur, E. C., Emera, D., Sheikh, S. Z., Grützner, F., Bauersachs, S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.052 · Cited by 255

Dynamics of immunoglobulins at the feto-maternal interface

Saji, F. (1999) · Reviews of Reproduction · doi:10.1530/ror.0.0040081 · Cited by 255

Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms‐like tyrosine kinase 1 and soluble endoglin in the prediction of pre‐eclampsia: a systematic review and meta‐analysis

Kleinrouweler, C. E., Wiegerinck, M. M. J., Ris‐Stalpers, C., Bossuyt, P. M., van der Post, J., von Dadelszen, P., Mol, B. W., & Pajkrt, E. (2012) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2012.03311.x · Cited by 254

Four-cell stage mouse blastomeres have different developmental properties

Piotrowska-Nitsche, K., Perea-Gómez, A., Haraguchi, S., & Zernicka‐Goetz, M. (2005) · Development · doi:10.1242/dev.01602 · Cited by 253

Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth

Simmons, D. G., Natale, D. R. C., Bégay, V., et al. (2008) · Development · doi:10.1242/dev.020099 · Cited by 252

Serotonin modulates the response of embryonic thalamocortical axons to netrin-1

Bonnin, A., Torii, M., Wang, L., RAKIC, P. T., & Levitt, P. R. (2007) · Nature Neuroscience · doi:10.1038/nn1896 · Cited by 249

Reflections on the Evolution of Piscine Viviparity

Wourms, J. P., & Lombardi, J. (1992) · American Zoologist · doi:10.1093/icb/32.2.276 · Cited by 242

Early Pregnancy Prediction of Preeclampsia in Nulliparous Women, Combining Clinical Risk and Biomarkers

Kenny, L. C., Black, M. A., Poston, L., Taylor, R. S., Myers, J., Baker, P. N., McCowan, L. M. E., Simpson, N., Dekker, G., Roberts, C. T., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03578 · Cited by 237

Learning From the Placenta

Staff, A. C., Dechend, R., & Pijnenborg, R. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.157743 · Cited by 237

Genetic basis of cell–cell fusion mechanisms

Aguilar, P. S., Baylies, M. K., Fleißner, A., Helming, L., Inoue, N., Podbilewicz, B., Wang, H., & Wong, M. H. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.01.011 · Cited by 232

Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst

Rayón, T., Menchero, S., Nieto, A., Xenopoulos, P., Crespo, M., Cockburn, K., Cañón, S., Sasaki, H., Hadjantonakis, A., de la Pompa, J. L., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.019 · Cited by 231

Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation

Dahl, K. D. C., Fryer, B. H., Mack, F. A., Compernolle, V., Maltepe, E., Adelman, D. M., Carmeliet, P., & Simon, M. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10479-10491.2005 · Cited by 229

Transcription factor AP-2γ is essential in the extra-embryonic lineages for early postimplantation development

Auman, H. J., Nottoli, T., Lakiza, O., Winger, Q. A., Donaldson, S., & Williams, T. (2002) · Development · doi:10.1242/dev.129.11.2733 · Cited by 226

A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2

Esnault, C., Priet, S., Ribet, D., Vernochet, C., Brüls, T., Lavialle, C., Weissenbach, J., & Heidmann, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807413105 · Cited by 226

Placental adaptations to the maternal–fetal environment: implications for fetal growth and developmental programming

Sandovici, I., Hoelle, K., Angiolini, E., & Constância, M. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.03.017 · Cited by 224

A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast

Dupressoír, A., Vernochet, C., Harper, F., Guégan, J., Dessen, P., Pierron, G., & Heidmann, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112304108 · Cited by 223

REPRODUCTIVE ADAPTATIONS AMONG VIVIPAROUS FISHES (CYPRINODONTIFORMES: POECILIIDAE)

Thibault, R. E., & Schultz, R. J. (1978) · Evolution · doi:10.1111/j.1558-5646.1978.tb00648.x · Cited by 222

Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning

Donnison, M. J., Beaton, A., Davey, H. W., Broadhurst, R. B., L'Huillier, P. J., & Pfeffer, P. (2005) · Development · doi:10.1242/dev.01819 · Cited by 221

Cell Therapy of Peripheral Arterial Disease

Raval, Z., & Losordo, D. W. (2013) · Circulation Research · doi:10.1161/circresaha.113.300565 · Cited by 213

Critical Function of AP-2gamma/TCFAP2C in Mouse Embryonic Germ Cell Maintenance1

Weber, S., Eckert, D., Nettersheim, D., et al. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.078717 · Cited by 213

Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro.

Huppertz, B., Frank, H., Reister, F., Kingdom, J. C., Korr, H., & Kaufmann, P. (1999) · PubMed · Cited by 209

Prevention of preterm birth: Harnessing science to address the global epidemic

Rubens, C. E., Sadovsky, Y., Muglia, L. J., Gravett, M. G., Lackritz, E., & Gravett, C. A. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009871 · Cited by 202

The vascular endothelial growth factor family in adverse pregnancy outcomes

Andraweera, P. H., Dekker, G., & Roberts, C. T. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms011 · Cited by 202

Placental nutrient supply and fetal growth

Desforges, M., & Sibley, C. P. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082765md · Cited by 199

Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice: Undernutrition and placental phenotype

Coan, P. M., Vaughan, O. R., Sekita, Y., Finn, S. L., Burton, G. J., Constancia, M., & Fowden, A. L. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181214 · Cited by 199

Placental Oxygen Consumption. Part I: In Vivo Studies—A Review

Carter, A. M. (2000) · Placenta · doi:10.1053/plac.1999.0513 · Cited by 196

CD98 at the crossroads of adaptive immunity and cancer

Cantor, J. M., & Ginsberg, M. H. (2012) · Journal of Cell Science · doi:10.1242/jcs.096040 · Cited by 194

Pathophysiology of ischemic placental disease

Roberts, J. M. (2014) · Seminars in Perinatology · doi:10.1053/j.semperi.2014.03.005 · Cited by 184

Maintenance of mouse trophoblast stem cell proliferation by TGF-β/activin

Erlebacher, A., Price, K. A., & Glimcher, L. H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.07.032 · Cited by 184

Transcription Factor Gene AP-2γ Essential for Early Murine Development

Werling, U., & Schorle, H. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.9.3149-3156.2002 · Cited by 183

Both Microtubule-Stabilizing and Microtubule-Destabilizing Drugs Inhibit Hypoxia-Inducible Factor-1α Accumulation and Activity by Disrupting Microtubule Function

Escuín, D., Kline, E. R., & Giannakakou, P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4095 · Cited by 183

The Evolution of Live-Bearing in Lizards and Snakes

Shine, R., & Bull, J. J. (1979) · The American Naturalist · doi:10.1086/283444 · Cited by 175

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia

Hunkapiller, N. M., Gasperowicz, M., Kapidzic, M., Plaks, V., Maltepe, E., Kitajewski, J., Cross, J. C., & Fisher, S. J. (2011) · Development · doi:10.1242/dev.066589 · Cited by 171

Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta

Maltepe, E., Krampitz, G. W., Okazaki, K. M., Red-Horse, K., Mak, W., Simon, M. C., & Fisher, S. J. (2005) · Development · doi:10.1242/dev.01923 · Cited by 169

Hypoxia-induced Angiogenesis during Carcinogenesis

Choe, G.-S., Bae, M.-G., Jeong, J.-W., Mun, H.-E., & Kim, G.-W. (2003) · BMB Reports · doi:10.5483/bmbrep.2003.36.1.120 · Cited by 166

Functional Characterization of the Human Placental Fusogenic Membrane Protein Syncytin 21

Chen, C., Chen, L., Yang, S.-R., Chen, C., Ko, C.-C., Chang, G., & Chen, H. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.069765 · Cited by 166

Identification of an endogenous retroviral envelope gene with fusogenic activity and placenta-specific expression in the rabbit: a new "syncytin" in a third order of mammals

Heidmann, O., Vernochet, C., Dupressoír, A., & Heidmann, T. (2009) · Retrovirology · doi:10.1186/1742-4690-6-107 · Cited by 165

Functional analyses of placental protein 13/galectin‐13

Than, N. G., Pick, E., Bellyei, S., et al. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04004.x · Cited by 165

Signaling pathways in mouse and human trophoblast differentiation: a comparative review

Soncin, F., Natale, D. R. C., & Parast, M. M. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1794-x · Cited by 162

Trophoblast Stem Cells1

Roberts, R. M., & Fisher, S. J. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.088724 · Cited by 159

The prolactin family: effectors of pregnancy-dependent adaptations

Soares, M. J., Konno, T., & Alam, S. M. K. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.02.005 · Cited by 158

Maternal hypoxia activates endovascular trophoblast cell invasion

Rosario, G. X., Konno, T., & Soares, M. J. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2007.12.007 · Cited by 156

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment

Guzman-Ayala, M., Ben-Haim, N., Beck, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405429101 · Cited by 156

Review: Transport across the placenta of mice and women

Dilworth, M. R., & Sibley, C. P. (2013) · Placenta · doi:10.1016/j.placenta.2012.10.011 · Cited by 155

Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation

Red‐Horse, K., Rivera, J., Schanz, A., Zhou, Y., Winn, V., Kapidzic, M., Maltepe, E., Okazaki, K., Kochman, R., Vo, K. C., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27306 · Cited by 155

Polyol Concentrations in the Fluid Compartments of the Human Conceptus during the First Trimester of Pregnancy: Maintenance of Redox Potential in a Low Oxygen Environment

Jauniaux, E., Hempstock, J., Teng, C., Battaglia, F. C., & Burton, G. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1513 · Cited by 153

Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia

Kudo, Y., Boyd, C. A. R., Sargent, I. L., & Redman, C. W. G. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(03)00043-7 · Cited by 153

Developmental Bias in Cleavage-Stage Mouse Blastomeres

Tabansky, I., Lenarcic, A., Draft, R. W., Loulier, K., Keskin, D. B., Rosains, J., Rivera‐Feliciano, J., Lichtman, J. W., Livet, J., Stern, J. N. H., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.10.054 · Cited by 151

Intracranial Hemorrhage During Extracorporeal Membrane Oxygenation in Neonates

Cilley, R. E., Zwischenberger, J. B., Andrews, A. F., et al. (1986) · PEDIATRICS · doi:10.1542/peds.78.4.699 · Cited by 145

Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C

Zhou, Y., Bellingard, V., Feng, K.-T., McMaster, M., & Fisher, S. J. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00449-4 · Cited by 143

The yolk syncytial layer in early zebrafish development

Carvalho, L., & Heisenberg, C. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.06.009 · Cited by 143

Life-history correlates of the evolution of live bearing in fishes

Goodwin, N. B., Dulvy, N. K., & Reynolds, J. D. (2002) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2001.0958 · Cited by 141

Ancestral capture of syncytin-Car1 , a fusogenic endogenous retroviral envelope gene involved in placentation and conserved in Carnivora

Cornelis, G., Heidmann, O., Bernard-Stoecklin, S., Reynaud, K., Veron, G., Mulot, B., Dupressoír, A., & Heidmann, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115346109 · Cited by 140

Expression of the Fusogenic HERV-FRD Env Glycoprotein (Syncytin 2) in Human Placenta is Restricted to Villous Cytotrophoblastic Cells

Malassiné, A., Blaise‐Boisseau, S., Handschuh, K., Lalucque, H., Dupressoír, A., Evain‐Brion, D., & Heidmann, T. (2006) · Placenta · doi:10.1016/j.placenta.2006.03.001 · Cited by 139

Development of the hemochorial maternal vascular spaces in the placenta through endothelial and vasculogenic mimicry

Rai, A., & Cross, J. C. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.01.015 · Cited by 139

Maternal Prepregnancy Body Mass Index and Risk of Spontaneous Preterm Birth

Shaw, G. M., Wise, P. H., Mayo, J. A., et al. (2014) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12125 · Cited by 136

Angiogenic Factors in Preeclampsia and Related DisordersPreprint

Cerdeira, A. S., & Karumanchi, S. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006585 · Cited by 136

Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the mouse

Uy, G. D., Downs, K. M., & Gardner, R. L. (2002) · Development · doi:10.1242/dev.129.16.3913 · Cited by 134

Chapter 18 Lactogenic hormone regulation of maternal behavior

Mann, P. E., & Bridges, R. S. (2001) · Progress in Brain Research · doi:10.1016/s0079-6123(01)33019-4 · Cited by 133

Calcium channels, transporters and exchangers in placenta: a review

Belkacemi, L., Bédard, I., Simoneau, L., & Lafond, J. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.06.010 · Cited by 133

Egg size, embryonic development time and ovoviviparity in Drosophila species

Markow, T. A., Beall, S., & Matzkin, L. M. (2008) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2008.01649.x · Cited by 132

The developmental disruptions of serotonin signaling may involved in autism during early brain development

Yang, C.-J., Tan, H.-P., & Du, Y.-J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.021 · Cited by 132

Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo

Piotrowska-Nitsche, K., & Zernicka‐Goetz, M. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.11.014 · Cited by 132

Sperm-Storage Defects and Live Birth in Drosophila Females Lacking Spermathecal Secretory Cells

Schnakenberg, S. L., Matias, W. R., & Siegal, M. L. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001192 · Cited by 129

Annexin V is critical in the maintenance of murine placental integrity

Wang, X., Campos, B., Kaetzel, M. A., et al. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70674-5 · Cited by 129

Review: Marsupials: Placental Mammals with a Difference

Renfree, M. B. (2010) · Placenta · doi:10.1016/j.placenta.2009.12.023 · Cited by 129

Prevention of Preterm Parturition

Iams, J. D. (2014) · New England Journal of Medicine · doi:10.1056/nejmcp1103640 · Cited by 129

Psychiatric Disorders in Extremely Preterm Children: Longitudinal Finding at Age 11 Years in the EPI

Johnson, S., Hollis, C., Kochhar, P., Hennessy, E., Wolke, D., & Marlow, N. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.02.002 · Cited by 128

Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian developmentPreprint

Gonzalez, M., Tachibana, K.-E. K., Adams, D. J., et al. (2006) · Genes & Development · doi:10.1101/gad.379706 · Cited by 127

Reproductive biology of lamnoid sharks

Gilmore, R. G. (1993) · Environmental Biology of Fishes · doi:10.1007/bf00842907 · Cited by 127

Ischemic placental disease: A unifying concept for preeclampsia, intrauterine growth restriction, and placental abruption

Ananth, C. V. (2014) · Seminars in Perinatology · doi:10.1053/j.semperi.2014.03.001 · Cited by 125

Human Placental Hypoxia-Inducible Factor-1α Expression Correlates with Clinical Outcomes in Chronic Hypoxia in Vivo

Zamudio, S., Wu, Y., Ietta, F., Rolfo, A., Cross, A., Wheeler, T., Post, M., Illsley, N. P., & Caniggia, I. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.061185 · Cited by 124

Deep placentation

Pijnenborg, R., Vercruysse, L., & Brosens, I. A. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2010.10.009 · Cited by 123

Metabolic and circulatory studies of fetal lamb at midgestation

Bell, A. W., Kennaugh, J. M., Battaglia, F. C., Makowski, E. L., & Meschia, G. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.250.5.e538 · Cited by 122

EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation

Red‐Horse, K., Kapidzic, M., Zhou, Y., et al. (2005) · Development · doi:10.1242/dev.01971 · Cited by 120

Pharmacologic Neuroprotective Strategies in Neonatal Brain Injury

Juul, S. E., & Ferriero, D. M. (2013) · Clinics in Perinatology · doi:10.1016/j.clp.2013.09.004 · Cited by 119

Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation

Erlich, J., Parry, G. C., Fearns, C., Müller, M., Carmeliet, P., Luther, T., & Mackman, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8138 · Cited by 118

Reproductive biology of lamnoid sharks

Gilmore, R. G. (1993) · Developments in environmental biology of fishes · doi:10.1007/978-94-017-3450-9_9 · Cited by 118

Where the O2goes to: preservation of human fetal oxygen delivery and consumption at high altitude

Postigo, L., Heredia, G., Illsley, N. P., Torricos, T., Dolan, C., Echalar, L., Tellez, W., Maldonado, I., Brimacombe, M., Balanza, E., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163634 · Cited by 115

Establishment of Human Trophoblast Progenitor Cell Lines from the Chorion

Genbačev, O., Donne, M. L., Kapidzic, M., Gormley, M. J., Lamb, J. D., Gilmore, J., Larocque, N., Goldfien, G. A., Zdravkovic, T., McMaster, M., et al. (2011) · Stem Cells · doi:10.1002/stem.686 · Cited by 115

Live birth in the Devonian period

Long, J. A., Trinajstic, K. M., Young, G. C., et al. (2008) · Nature · doi:10.1038/nature06966 · Cited by 114

Modulation of phosphatidylserine epitope expression by BeWo cells during forskolin treatment

LYDEN, T. W., Ah-Kau, N. G., & Rote, N. S. (1993) · Placenta · doi:10.1016/s0143-4004(05)80259-0 · Cited by 113

Placental Syncytium Forms a Biophysical Barrier against Pathogen Invasion

Zeldovich, V. B., Clausen, C. H., Bradford, E., Fletcher, D. A., Maltepe, E., Robbins, J. R., & Bakardjiev, A. I. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003821 · Cited by 113

Amino Acid Interconversions in the Fetal-Placental Unit: The Animal Model and Human Studies In Vivo

Cetin, I. (2001) · Pediatric Research · doi:10.1203/00006450-200102000-00004 · Cited by 112

Reproductive Adaptations Among Viviparous Fishes (Cyprinodontiformes: Poeciliidae)

Thibault, R. E., & Schultz, R. J. (1978) · Evolution · doi:10.2307/2407600 · Cited by 109

Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth?

Illsley, N. P., Caniggia, I., & Zamudio, S. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082798ni · Cited by 107

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice

Li, M., Yee, D., Magnuson, T., Smithies, O., & Caron, K. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28462 · Cited by 106

Preeclampsia and future cardiovascular risk

Newstead, J., von Dadelszen, P., & Magee, L. A. (2007) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.5.2.283 · Cited by 105

Production and utilization of amino acids by ovine placenta in vivo

Chung, M., Teng, C. C., Timmerman, M., Meschia, G., & Battaglia, F. C. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.1.e13 · Cited by 104

Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype

Weier, J. F., Weier, H. G., Jung, C. J., Gormley, M. J., Zhou, Y., Chu, L. W., Genbačev, O., Wright, A. A., & Fisher, S. J. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.035 · Cited by 101

Early development and embryology of the platypus

Hughes, R., & Hall, L. S. (1998) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1998.0269 · Cited by 99

Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cells

Sood, R., Kalloway, S., Mast, A. E., Hillard, C. J., & Weiler-Guettler, H. (2005) · Blood · doi:10.1182/blood-2005-10-4111 · Cited by 99

c-Met-Dependent Multipotent Labyrinth Trophoblast Progenitors Establish Placental Exchange Interface

Ueno, M., Lee, L. K., Chhabra, A., Kim, Y. J., Sasidharan, R., Handel, B. V., Wang, Y., Kamata, M., Kamran, P., Sereti, K., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.10.019 · Cited by 93

The Human Placenta Remodels the Uterus by Using a Combination of Molecules That Govern Vasculogenesis or Leukocyte Extravasation

Zhou, Y., Genbačev, O., & Fisher, S. J. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03211.x · Cited by 87

Trophoblast Giant-Cell Differentiation Involves Changes in Cytoskeleton and Cell Motility

Parast, M. M., Aeder, S. E., & Sutherland, A. E. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0102 · Cited by 87

Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport

Dilworth, M., Kusinski, L. C., Cowley, E. J., Ward, B. S., Husain, S. M., Constância, M., Sibley, C. P., & Glazier, J. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911710107 · Cited by 85

The contribution of genetic and environmental factors to the duration of pregnancy

York, T. P., Eaves, L. J., Neale, M. C., & Strauss, J. F. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.10.001 · Cited by 84

Placenta Growth Factor and Vascular Endothelial Growth Factor are Co-Expressed During Early Embryonic Development

Achen, M. G., Gad, J. M., Stacker, S. A., & Wilks, A. F. (1997) · Growth Factors · doi:10.3109/08977199709002113 · Cited by 84

Trophoblast Fusion

Huppertz, B., & Gauster, M. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0763-4_6 · Cited by 84

Energy metabolism and glycolysis in human placental trophoblast cells during differentiation

Bax, B. E., & Bloxam, D. L. (1997) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(96)00169-7 · Cited by 83

Trophoblast and hypoblast in the monotreme, marsupial and eutherian mammal: evolution and origins

Selwood, L., & Johnson, M. H. (2006) · BioEssays · doi:10.1002/bies.20360 · Cited by 82

Maternal body-volume as a constraint on reproductive output in lizards: evidence from the evolution of viviparity

Qualls, C. P., & Shine, R. (1995) · Oecologia · doi:10.1007/bf00328427 · Cited by 81

Procoagulant and Anticoagulant Mechanisms in Human Placenta

Lanir, N., Aharon, A., & Brenner, B. (2003) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2003-38833 · Cited by 81

Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development

Georgiades, P., & Rossant, J. (2006) · Development · doi:10.1242/dev.02277 · Cited by 80

Receptor-mediated uptake and transport of macromolecules in the human placenta

Schneider, H., & Miller, R. K. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082773hs · Cited by 79

Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles.

Arkwright, P. D., Rademacher, T. W., Dwek, R. A., & Redman, C. W. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116515 · Cited by 79

Mechanisms of trophectoderm fate specification in preimplantation mouse development

Sasaki, H. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01158.x · Cited by 78

Calponin 3 Regulates Actin Cytoskeleton Rearrangement in Trophoblastic Cell Fusion

Shibukawa, Y., Yamazaki, N., Kumasawa, K., Daimon, E., Tajiri, M., Okada, Y., Ikawa, M., & Wada, Y. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-03-0261 · Cited by 77

Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal–fetal interface in the mouse placenta

Hirashima, M., Lu, Y., Byers, L., & Rossant, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2635424100 · Cited by 76

Microtubules and biotic interactions

Hardham, A. R. (2013) · The Plant Journal · doi:10.1111/tpj.12171 · Cited by 73

Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placentaPreprint

Mould, A. W., Morgan, M. A. J., Li, L., et al. (2012) · Genes & Development · doi:10.1101/gad.199828.112 · Cited by 72

Trophoblast development

Pfeffer, P., & Pearton, D. J. (2012) · Reproduction · doi:10.1530/rep-11-0374 · Cited by 72

Geminin Escapes Degradation in G1 of Mouse Pluripotent Cells and Mediates the Expression of Oct4, Sox2, and Nanog

Yang, V. S., Carter, S. A., Hyland, S. J., Tachibana-Konwalski, K., Laskey, R. A., & Gonzalez, M. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.026 · Cited by 69

Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells − implication for placental cell fusion

Dalton, P., Christian, H., Redman, C. W. G., et al. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05806.x · Cited by 68

Single-cell reconstruction of the early maternal–fetal interface in humans

Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358

Pathophysiology from preconception, during pregnancy, and beyond.

Hivert, M.-F., Backman, H., Benhalima, K., Catalano, P., Desoye, G., Immanuel, J., McKinlay, C. J. D., Meek, C. L., Nolan, C. J., Ram, U., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00827-4 · Cited by 186

Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2

Ashary, N., Bhide, A., Chakraborty, P., Colaco, S., Mishra, A., Chhabria, K., Jolly, M. K., & Modi, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00783 · Cited by 121

Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals

Padmanabhan, V., Song, W., & Puttabyatappa, M. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa035 · Cited by 103

Recent advances in liver engineering with decellularized scaffold

Dai, Q., Jiang, W., Huang, F., Song, F., Zhang, J., & Zhao, H. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.831477 · Cited by 57

Conservation at the uterine–placental interface

Scott, R. L., Vu, H., Jain, A., Iqbal, K., Tuteja, G., & Soares, M. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210633119 · Cited by 33

Conservation at the uterine-placental interfacePreprint

Scott, R. L., Vu, H. T. H., Jain, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.14.496152 · Cited by 1

The ever growing complexity of trophoblast epigenetics

Schmidt, K. A. (2018)

A simple in vivo approach to investigate invasive trophoblast cells

Arroyo, J. A., Konno, T., Khalili, D. C., et al. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.051993ja · Cited by 16

The metrial gland is more than a mesometrial lymphoid aggregate of pregnancy

Pijnenborg, R. (2000) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(99)00054-6 · Cited by 14