Transforming the Treatment of Schizophrenia in the United States: The RAISE Initiative
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The schizophrenia spectrum disorders are neurodevelopmental illnesses with a lifetime prevalence near 1%, producing extensive functional impairment and low expectations for recovery. Until recently, treatment in the United States has largely attempted to stabilize individuals with chronic schizophrenia. The identification and promotion of evidence-based practices for schizophrenia via the Patient Outcomes Research Team, combined with international studies supporting the value of early intervention, provided the foundation for the Recovery After an Initial Schizophrenia Episode (RAISE) project. The RAISE studies further supported the value of reducing the duration of untreated psychosis and providing a multi-element treatment called coordinated specialty care (CSC) to improve outcomes for patients in usual treatment settings. Although CSC programs have proliferated rapidly in the United States, many challenges remain in the treatment and recovery of individuals with schizophrenia in the aftermath of RAISE.
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Earlier initiation of appropriate treatment has been shown to improve patient outcomes.
“The ICD-11's shorter duration requirement, along with the introduction of a first-episode course qualifier (also introduced in the DSM-5), is intended to encourage earlier initiation of appropriate treatment, which has been shown to improve patient outcomes 38 .”
From An organization‐ and category‐level comparison of diagnostic requirements for mental disorders in <scp>ICD</scp> ‐11 and <scp>DSM</scp> ‐5 (2021) · cites this paper as [38]
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Self-citationKlodnick, V. V., Brenits, A., Johnson, R. P., Cohen, D. A., Paauw, M. A., Zeidner, E., & Fagan, M. A. (2023) · Evaluation and Program Planning · doi:10.1016/j.evalprogplan.2023.102268 · Cited by 4 · see citing works
Rolin, S. A., Caffrey, D., Flores, M. G., Pope, L. G., Mootz, J. J., Bello, I., Nossel, I. R., Compton, M. T., Stanley, B., Wainberg, M. L., et al. (2024) · Early Intervention in Psychiatry · doi:10.1111/eip.13543 · Cited by 5 · see citing works
Self-citationStructural Characteristics of Early Psychosis Intervention Network (EPINET) Programs
George, P., Spark, T. L., Devora, A., Mukai, R., Cosgrove, J. A., Goldman, H. H., & Rosenblatt, A. (2026) · Psychiatric Services · doi:10.1176/appi.ps.20250320 · Cited by 3 · see citing works
Self-citationThe Recovery Model and Other Rehabilitative Approaches
Ragins, M., & Sunkel, C. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_157 · Cited by 3 · see citing works
Bargagli, A. M., Cascini, S., Forastiere, A., Calandrini, E., Cesaroni, G., Marino, C., Davoli, M., & Agabiti, N. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06151-x · Cited by 3 · see citing works
Calkins, M. E., Jumper, M. B. E., Ered, A., Dong, F., Sarpal, D. K., Baker, K. K., Bencivengo, D. J., Margolis, R. L., Buchanan, R. W., Boumaiz, Y., et al. (2025) · Early Intervention in Psychiatry · doi:10.1111/eip.70031 · Cited by 3 · see citing works
Service Use Following First-Episode Schizophrenia Among Commercially Insured Youth
Gilmer, T., van der Ven, E., Susser, E., Dixon, L. B., & Olfson, M. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz031 · Cited by 3 · see citing works
Self-citationGetting in Early: Early Intervention Services for Psychosis
Gates, J., & Killackey, E. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815012-2.00024-9 · Cited by 3 · see citing works
Klodnick, V. V., Johnson, R. P., Cohen, D. A., Fagan, M. A., Fetzer, P., & Clark, H. B. “. (2022) · Social Work in Mental Health · doi:10.1080/15332985.2022.2118007 · Cited by 3 · see citing works
What Explains Changes in Availability of Specialty Mental Health Services in Organized Settings?
Newton, H., Humensky, J. L., Goldman, H. H., & Busch, S. H. (2022) · Milbank Quarterly · doi:10.1111/1468-0009.12592 · Cited by 3 · see citing works
Self-citationThe Recovery Model and Other Rehabilitative Approaches
Ragins, M., & Sunkel, C. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_157-1 · Cited by 3 · see citing works
The Challenge of Nonadherence in Schizophrenia
Lawrence, R. E., & Dixon, L. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-12665-0_4 · Cited by 3 · see citing works
Self-citationEarly interventions for psychosis
Goldman, M. B. (2021) · Current Psychiatry · doi:10.12788/cp.0176 · Cited by 3 · see citing works
Learning health systems for first-episode psychosis: Insights from North America
Srihari, V. H., & Keshavan, M. S. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.10.025 · Cited by 2 · see citing works
Self-citationA systematic review of psychosis in social work literature
Chaudhry, S., Roy, R. J., Weiss, A. L., & Hansel, T. C. (2022) · Social Work in Mental Health · doi:10.1080/15332985.2022.2029667 · Cited by 2 · see citing works
Ghose, S. S., George, P., Goldman, H. H., Daley, T. C., Dixon, L. B., Ren, W., Zhu, X., & Rosenblatt, A. (2022) · Psychiatric Services · doi:10.1176/appi.ps.202100676 · Cited by 2 · see citing works
Self-citationSchizophrenia and Psychosis: Treatment and Follow-Up
Thompson, E. C., Meinhardt, N., & McClellan, J. (2024) · Issues in clinical child psychology · doi:10.1007/978-3-031-62749-1_15 · Cited by 2 · see citing works
Bello, I., Stefančić, A., Florence, A. C., Wall, M. M., Radigan, M., Malinovsky, I., Nossel, I. R., Mathai, C. M., Cabassa, L. J., Fidaleo, K., et al. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.03.033 · Cited by 2 · see citing works
Self-citationThe EnTRy Program: Expanding Coordinated Specialty Care Beyond Early Psychosis
Fried, J., McQuistion, H. L., Marrelli, J., Hampton, M. C., Wu, L., LeGeros, A. R., Lanina, O., & Frankle, W. G. (2025) · Community Mental Health Journal · doi:10.1007/s10597-025-01491-8 · Cited by 2 · see citing works
School-Based Approaches in Youth with Psychosis
Hines, S., & Coman, D. C. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.08.014 · Cited by 2 · see citing works
Schizophrenia or Other Primary Psychotic Disorders
Gäebel, W., & Salveridou‐Hof, E. (2023) · Cambridge University Press eBooks · doi:10.1017/9781009182232.004 · Cited by 2 · see citing works
Intervensi Social Skills Training Pada Pasien Skizofrenia: Reviu Literatur
H, S. H. S., & Mustikasari, M. (2023) · Health Information Jurnal Penelitian · doi:10.36990/hijp.v15i3.1151 · Cited by 1 · see citing works
Psychotic Experiences Questionnaire. Part 2
Анатольевна, С. О., Truevtsev, D. V., & Zhirnova, O. V. (2024) · Neurology Bulletin · doi:10.17816/nb632357 · Cited by 1 · see citing works
Johnson, R. P., LaPelusa, B., Mayhue, A., Schneider, A., Crowe, A. N., Diggins, T., Brown, A., Spencer, E., Cohen, D. A., & Klodnick, V. V. (2024) · Community Mental Health Journal · doi:10.1007/s10597-024-01431-y · Cited by 1 · see citing works
Dixon, L. B., & Goldman, H. H. (2022) · Community Mental Health Journal · doi:10.1007/s10597-022-00960-8 · Cited by 1 · see citing works
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Early Psychosis and the Prevention and Mitigation of Serious Mental Illness
Bello, I., Nossel, I. R., & Dixon, L. B. (2022) · Springer eBooks · doi:10.1007/978-3-031-10239-4_43 · Cited by 1 · see citing works
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Psicose e drogas: estado mental de risco e primeiro episódio psicótico em usuários de maconha
Moreira, E. C. (2022) · EDUFBA eBooks · doi:10.7476/9786556305059 · Cited by 1 · see citing works
Oluwoye, O., Lissau, A., Stokes, S. D., Selloni, A. T., James, N., Amiri, S., McDonell, M. G., & Anglin, D. M. (2023) · Implementation Science Communications · doi:10.1186/s43058-023-00476-6 · Cited by 1 · see citing works
Kopelovich, S. L., Straub, K. T., Vaswani-Bye, A., Brian, R., & Monroe‐DeVita, M. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2024.12.011 · Cited by 1 · see citing works
Building a two-state learning healthcare system for persons with first episode psychosis
Marsteller, J. A., Goldberg, R. W., Boumaiz, Y., Jumper, M. B. E., Taylor, J., Saravana, A., Buchanan, R. W., Chengappa, K. N. R., Conroy, C. G., Dickerson, F., et al. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.02.004 · Cited by 1 · see citing works
Early Intervention in Psychosis: From Science to Services
Smith, T. E., & Dixon, L. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-11908-9_11 · Cited by 1 · see citing works
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Self-citationSuryaputra, D., & Adik, W. (2019) · Strengthening Hospital Competitiveness to Improve Patient Satisfaction and Better Health Outcomes · doi:10.26911/the6thicph-fp.04.10
Stacy, M. A., & Davidson, C. A. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108951760.006
Implementing Evidence-Based Psychosocial Interventions for Psychosis
Glenthøj, L. B., Jankowski, S. E., Dixon, L. B., & Nordentoft, M. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108951760.008
Self-citationMeasuring Success in First Episode Psychosis
McKinley, E. (2022) · doi:10.15760/honors.1268
- Authors
- Dixon, L. B., Goldman, H. H., Srihari, V. H., & Kane, J. M.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of Maryland, Baltimore (US)
- Yale University (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Venue
- Annual Review of Clinical Psychology
- Publisher
- Annual Reviews
- Published
- 2018-05-07
- Volume
- 14
- Issue
- 1
- Pages
- 237-258
- ISSN
- 1548-5943 (ISSN-L)
- 1548-5951
- PMC
- PMC8990328
- OpenAlex
- W2782714767
- Cited by
- 112
- References
- 110
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 13 · 2023: 12 · 2022: 23 · 2021: 13 · 2020: 9 · 2019: 15 · 2018: 6
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (RC1MH088971, R01MH120597)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, coordinated specialty care, early intervention, duration of untreated psychosis, schizophrenia spectrum disorders, recovery, evidence-based practice, functional disability
- MeSH terms
- Humans, Mental Health Services, Psychotic Disorders, Schizophrenia, United States, Program Development, Evidence-Based Practice
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