The DOI matches its Crossref record, with a small difference in title or year; 218 of the 218 references it cites were found in a registry or an index.
The Fluid Mechanics of Cancer and Its Therapy
Abstract
Fluid mechanics is involved in the growth, progression, metastasis, and therapy of cancer. Blood vessels transport oxygen and nutrients to cancerous tissues, provide a route for metastasizing cancer cells to distant organs, and deliver drugs to tumors. The irregular and leaky tumor vasculature is responsible for increased interstitial pressure in the tumor microenvironment, whereas multiscale flow-structure interaction processes control tumor growth, metastasis, and nanoparticle-mediated drug delivery. We outline these flow-mediated processes, along with related experimental and computational methods for the diagnosis, predictive modeling, and therapy of cancer.
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“In contrast to normal tissue, in which lymphatic vessels maintain fluid balance and facilitate macromolecule clearance, tumors exhibit deficient lymphatic drainage, leading to elevated IFP [149,150].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [150]
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Tumor angiogenesis: therapeutic implications
Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
The distribution of secondary growths in cancer of the breast.
Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 5,000
The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686
Research works printed but not linked: 10
- Dvorak HF, 1988, Am. J. Pathol., 133, 95
- Ide AG, 1939, Am. J. Roentgenol., 42, 891
- Jain RK, 1987, Cancer Res., 47, 3039
- Jain RK, 1988, Cancer Res., 48, 2641
- Leunig M, 1992, Cancer Res., 52, 6553
- Popel AS, 1979, Am. J. Physiol., 237, H681
- 10.1016/0008-6363(96)00065-X · DOI · Paper page
- Schmid-Schonbein GW, 1985, Int. J. Microcirc. Clin. Exp., 4, 311
- Yuan F, 1994, Cancer Res., 54, 3352
- Yuan F, 1994, Cancer Res., 54, 4564
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Items 101–129 of 129
Abraham, A., Virdi, S., Herrero, N., Bryant, I., Nwakama, C., Jacob, M., Khaparde, G., Jordan, D., McCuddin, M., McKinley, S., et al. (2023) · Micromachines · doi:10.3390/mi14091653 · Cited by 3
Three Dimensional In Vitro Tumor Platforms for Cancer Discovery
Gadde, M., Marrinan, D., Michna, R. J., & Rylander, M. N. (2017) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-60511-1_5 · Cited by 4
Wu, Y. B., Guo, B., & Ghosh, G. (2015) · Annals of Biomedical Engineering · doi:10.1007/s10439-015-1254-2 · Cited by 4
Generalized Taylor dispersion of chiral microswimmers
Ogawa, K., & Ishimoto, K. (2025) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2024.0262 · Cited by 3
Kolitsi, L. I., Orova, M., & Yiantsios, S. G. (2022) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2022.169732 · Cited by 2
In vitro three-dimensional cancer metastasis modeling: Past, present, and future
Han, W., Yuan, W., Zhu, J., Fan, Q., Qu, J., & Liu, L. (2016) · Chinese Physics B · doi:10.1088/1674-1056/25/1/018709 · Cited by 2
Economides, A. E., Amoudruz, L., Litvinov, S., Alexeev, D., Nizzero, S., Hadjidoukas, P. E., Rossinelli, D., & Koumoutsakos, P. (2017) · Platform for Advanced Scientific Computing Conference (PASC) · doi:10.1145/3093172.3093226 · Cited by 2
Microfluidic Models of the Tumor Microenvironment
Chang, C.-S., Holter, J. C., & Song, J. W. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166013-00252 · Cited by 2
Traoré, M. A. (2014) · VTechWorks (Virginia Tech) · Cited by 2
Mohan, A., & Bagchi, P. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.10.004 · Cited by 1
Role of Computational Fluid Dynamics in Cancer
Eswari, S., Kumar, T. S., & Gupta, S. (2024) · Springer eBooks · doi:10.1007/978-981-99-7129-9_6 · Cited by 1
The Impact of Computational Fluid Mechanics on Cancer Research
Belisario, D. C., & Sigalotti, L. D. G. (2014) · Environmental science and engineering · doi:10.1007/978-3-319-00191-3_6 · Cited by 1
Engineered Microenvironments for Cancer Study
Balhouse, B. N., Ivey, J. W., & Verbridge, S. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-35321-2.00020-0 · Cited by 1
Studies of a Hybrid and Multiscale Tumor Growth Model via Isogeometric Analysis using PetIGA
Barbosa, P. W., Cortês, A., & Catabriga, L. (2017) · IEEE International Conference on Bioinformatics and Bioengineering (BIBE) · doi:10.1109/bibe.2017.00-76 · Cited by 1
Nath, S., Demirci, U., Hasan, T. G., Scarcelli, G., Rizvi, I., Franco, W., & Afshar, S. (2018) · Microfluidics, BioMEMS, and Medical Microsystems · doi:10.1117/12.2290372 · Cited by 1
Cancer: Strange Attractors and ComplexityPreprint
Uthamacumaran, A. (2019) · Preprints.org · doi:10.20944/preprints201906.0288.v1 · Cited by 1
Bucher, T. M., & Tafreshi, H. V. (2013) · Applied Physics Letters · doi:10.1063/1.4811167
Single Cell Deformation and Detachment Models of Shear Assay Measurements
Ani, C. J., Danyuo, Y., Odunsoya, S., Malatesta, K. A., & Soboyejo, W. O. (2015) · Advanced materials research · doi:10.4028/www.scientific.net/amr.1132.51
Fuh, K. F. (2016) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/26197
Gonzalez, A. M. P. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2017.tde-03032017-094509
Anomalous Confined Diffusion of Nanoparticles in Polymer Solutions
Zheng, P., Xue, C., & Qin, K. (2020) · International Conference on Control and Automation · doi:10.1109/icca51439.2020.9264374
Bindra, A. K. (2020) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/146514
Fuh, K. F., Shepherd, R. D., Withell, J. S., Kooistra, B. K., & Rinker, K. D. (2020) · Research Square · doi:10.21203/rs.3.rs-57689/v1
Fuh, K. F., Shepherd, R. D., Withell, J. S., Kooistra, B. K., & Rinker, K. D. (2020) · Research Square · doi:10.21203/rs.3.rs-57689/v2
Engineered microenvironments for cancer study
Balhouse, B. N., Ivey, J. W., Khan, Z. M., & Verbridge, S. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817827-0.00060-6 · Cited by 1
Cancer metastasis: How blood flow affects platelet–cancer cell interactions
Zhu, Z., Ye, T., Xia, Z., & Sun, N. (2025) · Applied Physics Letters · doi:10.1063/5.0282634
Akash, M. M. H., Yeasin, M., Mahmoudirad, S., Niloy, R. A., Mohammad, J., Reindl, K. M., Pandey, A., & Basu, S. K. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1746751
Etude des propriétés mécaniques intrinsèques d’un modèle de microtumeur in vitro
Guillaume, L. (2017) · theses.fr (ABES) · doi:10.70675/98eaf292zbc52z4451z8a14z84364523ff6b
Modeling of Tumor Cell Adhesion, Extravasation, and Sorting in a Microvascular System
Yan, W. W., Xiao, L. L., Cui, J. Y., & Fu, B. M. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-22285-5_13
Metadata
- Authors
- Koumoutsakos, P., Pivkin, I., & Milde, F.
- Affiliations
- ETH Zurich (CH)
- Università della Svizzera italiana (CH)
- Venue
- Annual Review of Fluid Mechanics
- Publisher
- Annual Reviews
- Published
- 2013-01-03
- Volume
- 45
- Issue
- 1
- Pages
- 325-355
- ISSN
- 0066-4189 (ISSN-L)
- 1545-4479
- OpenAlex
- W2096404892
- Cited by
- 129
- References
- 218
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 10 · 2018: 20 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 15 · 2013: 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Fluid Mechanics (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor vasculature, tumor microenvironment, metastasis, nanoparticle drug delivery, tumor growth, cancer therapy
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