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Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health
Open accessAbstract
Bile acids have emerged as important signaling molecules in the host, as they interact either locally or systemically with specific cellular receptors, in particular the farnesoid X receptor (FXR) and TGR5. These signaling functions influence systemic lipid and cholesterol metabolism, energy metabolism, immune homeostasis, and intestinal electrolyte balance. Through defined enzymatic activities, the gut microbiota can significantly modify the signaling properties of bile acids and therefore can have an impact upon host health. Alterations to the gut microbiota that influence bile acid metabolism are associated with metabolic disease, obesity, diarrhea, inflammatory bowel disease (IBD), Clostridium difficile infection, colorectal cancer, and hepatocellular carcinoma. Here, we examine the regulation of this gut-microbiota-liver axis in the context of bile acid metabolism and indicate how this pathway represents an important target for the development of new nutraceutical (diet and/or probiotics) and targeted pharmaceutical interventions.
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“The expansion of microbial BSH activity has increased the diversity of bile acids in the host (Joyce and Gahan, 2016).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Joyce and Gahan, 2016
Experimental — accuracy not yet measuredIn the citing paper
“Microbially derived secondary bile acids are hypothesized to be interkingdom signaling molecules due to their ability to influence the composition and function of the gut microbiota as well as host physiology (407, 408).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [408]
In the citing paper
“Bile that is not re-absorbed in terminal small intestine undergoes further transformation by the intestinal microbiota (Joyce and Gahan, 2016).”
From Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism (2017) · cites this paper as Joyce and Gahan, 2016
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“Furthermore, Blautia and Bifidobacterium species are involved in the transformation of host bile.”
From Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism (2017) · cites this paper as Joyce and Gahan, 2016
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Metadata
- Authors
- Joyce, S. A., & Gahan, C. G. M.
- Affiliations
- APC Microbiome Institute (IE)
- University College Cork (IE)
- Venue
- Annual Review of Food Science and Technology
- Publisher
- Annual Reviews
- Published
- 2016-02-28
- Volume
- 7
- Issue
- 1
- Pages
- 313-333
- ISSN
- 1941-1421 (ISSN-L)
- 1941-1413
- OpenAlex
- W2152714616
- Cited by
- 241
- References
- 135
- Citations by year
- 2026: 27 · 2025: 22 · 2024: 27 · 2023: 20 · 2022: 37 · 2021: 24 · 2020: 20 · 2019: 16 · 2018: 15 · 2017: 23 · 2016: 10
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Food Science and Technology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Board
- Science Foundation Ireland (SFI/12/RC/, 12/RC/2273, 12/RC/, SFI/12/RC/2273.)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- bile acids, gut microbiota, farnesoid X receptor, TGR5, bile acid metabolism, host-microbe interactions, probiotics, metabolic disorders, obesity, inflammatory bowel disease, Clostridium difficile infection, colorectal cancer, hepatocellular carcinoma, bile acid signaling
- MeSH terms
- Gastrointestinal Microbiome, Receptor, Farnesoid X-Activated, Aging, Bile Acids and Salts, Diet, Disease, Energy Metabolism, Health Status, Humans, Liver, Technology, Pharmaceutical, Signal Transduction, Weight Gain, Receptors, Cytoplasmic and Nuclear, Dietary Supplements, Probiotics
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