Cited by 192Schizophrenia research and treatmentGenetic Associations and EpidemiologyGenomic variations and chromosomal abnormalities

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Genetics of Schizophrenia: New Findings and Challenges

Gejman, Pablo V., Sanders, Alan R., Kendler, Kenneth S.·2011·Annual Review of Genomics and Human Genetics

DOI 10.1146/annurev-genom-082410-101459

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Abstract

The work conducted using genome-wide approaches during the past several years has invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The aggregate data increasingly support a combination of rare and common genetic variation in schizophrenia, a major role for polygenic inheritance, and a genetic overlap of schizophrenia and other psychiatric disorders, such as bipolar disorder and autism. The current and upcoming resequencing programs (full exomes to full genomes), in combination with the use of more informative genotyping arrays, will allow a more thorough dissection of the molecular genetics of the disorder. A main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia.

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Authors: Gejman, P. V., Sanders, A. R., & Kendler, K. S.
Affiliations: Endeavor Health (US)
Virginia Commonwealth University (US)
ORCID: Gejman, Pablo V.
Sanders, Alan R.
Kendler, Kenneth S.
Venue: Annual Review of Genomics and Human Genetics
Publisher: Annual Reviews
Published: 2011-09-22
Volume: 12
Issue: 1
Pages: 121-144
ISSN: 1527-8204 (ISSN-L)
1545-293X
DOI: 10.1146/annurev-genom-082410-101459
OpenAlex: W2103560303
Cited by: 183
References: 217
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 10 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 24 · 2012: 36
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Genomics and Human Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (RC2MH090030)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords: schizophrenia, genetic architecture, polygenic inheritance, rare variants, common genetic variants, genome-wide association study, resequencing
MeSH terms: Adoption, Mental Disorders, Humans, Schizophrenia, Twin Studies as Topic, Genome-Wide Association Study, Genetic Pleiotropy

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Genetics of Schizophrenia: New Findings and Challenges

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