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Genetics of Schizophrenia: New Findings and Challenges
Abstract
The work conducted using genome-wide approaches during the past several years has invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The aggregate data increasingly support a combination of rare and common genetic variation in schizophrenia, a major role for polygenic inheritance, and a genetic overlap of schizophrenia and other psychiatric disorders, such as bipolar disorder and autism. The current and upcoming resequencing programs (full exomes to full genomes), in combination with the use of more informative genotyping arrays, will allow a more thorough dissection of the molecular genetics of the disorder. A main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia.
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“Current models of schizophrenia suggest that the disorder is due to both common and rare gene mutations, copy-number variations, and possibly epigenetic factors [361], all of which can affect multiple brain neurotransmitter systems and multiple risk genes [362-364].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [361]
In the citing paper
“This observation is consistent with recent reports that similar copy number variants (CNVs) are found across many genomic loci in both ASD and schizophrenia (Cook and Scherer, 2008; Gejman et al., 2011; Moreno-De-Luca et al., 2010; Sanders et al., 2011).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Gejman et al., 2011
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Self-citation
Metadata
- Authors
- Gejman, P. V., Sanders, A. R., & Kendler, K. S.
- Affiliations
- Endeavor Health (US)
- Virginia Commonwealth University (US)
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2011-09-22
- Volume
- 12
- Issue
- 1
- Pages
- 121-144
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2103560303
- Cited by
- 183
- References
- 217
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 10 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 24 · 2012: 36
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Genomics and Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (RC2MH090030)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- schizophrenia, genetic architecture, polygenic inheritance, rare variants, common genetic variants, genome-wide association study, resequencing
- MeSH terms
- Adoption, Mental Disorders, Humans, Schizophrenia, Twin Studies as Topic, Genome-Wide Association Study, Genetic Pleiotropy
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