Heterogeneity of Human CD4 + T Cells Against Microbes

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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The regulation of IL-10 production by immune cells

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

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Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

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Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

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Temperature and adaptive immunity

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The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease

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The Th17/IL-17 Axis and Host Defense Against Fungal Infections

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PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity

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Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment?Preprint

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A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation

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Co-signaling receptors regulate T-cell plasticity and immune tolerance

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Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease

Akiyama, M., Suzuki, K., Yoshimoto, K., Yasuoka, H., Kaneko, Y., & Takeuchi, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.651357 · Cited by 46

The tumor immune-microenvironment in gastric cancer

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Single-Cell Analysis Reveals a CD4+ T-cell Cluster That Correlates with PD-1 Blockade Efficacy

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From IL-17 to IFN-γ in inflammatory skin disorders: Is transdifferentiation a potential treatment target?

Belpaire, A., van Geel, N., & Speeckaert, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.932265 · Cited by 46

Th17 Cells in Viral Infections—Friend or Foe?

Paiva, I. A., Badolato-Corrêa, J., Familiar-Macedo, D., & de‐Oliveira‐Pinto, L. M. (2021) · Cells · doi:10.3390/cells10051159 · Cited by 41

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

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Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T CellsPreprint

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Flow Cytometric-Based Analysis of Defects in Lymphocyte Differentiation and Function Due to Inborn Errors of Immunity

Ma, C. S., & Tangye, S. G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02108 · Cited by 40

Peripheral tissue chemokines: homeostatic control of immune surveillance T cells.

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CCR4+ Skin-Tropic Phenotype as a Feature of Central Memory CD8+ T Cells in Healthy Subjects and Psoriasis Patients

Casciano, F., Diani, M., Altomare, A., Granucci, F., Secchiero, P., Banfi, G., & Reali, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00529 · Cited by 39

Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’

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A Bacteriophage-Based, Highly Efficacious, Needle- and Adjuvant-Free, Mucosal COVID-19 Vaccine

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Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency

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Gold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structures

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Th17 Cells, Glucocorticoid Resistance, and Depression

Khantakova, J. N., Mutovina, A., Ayriyants, K. A., & Bondar, N. P. (2023) · Cells · doi:10.3390/cells12232749 · Cited by 36

Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen‐induced arthritis in mice

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The Role of CD4+ T Follicular Helper Cells in HIV Infection: From the Germinal Center to the Periphery

Thornhill, J. P., Fidler, S. J., Klenerman, P., Frater, J., & Phetsouphanh, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00046 · Cited by 36

TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf

Chang, Y., Bach, L., Hasiuk, M., Wen, L., Elmzzahi, T., Tsui, C., Gutiérrez-Melo, N., Steffen, T., Utzschneider, D. T., Raj, T., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.add4818 · Cited by 36

Human immunity

Casanova, J. (2025) · Journal of Human Immunity · doi:10.70962/jhi.20250001 · Cited by 34

Blood to skin recirculation of CD4 + memory T cells associates with cutaneous and systemic manifestations of psoriatic disease

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Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies

Tangye, S. G., Pelham, S. J., Deenick, E. K., & Ma, C. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700842 · Cited by 34

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease

Orlando, V., Manna, M. P. L., Goletti, D., Palmieri, F., Presti, E. L., Joosten, S. A., Mendola, C. L., Buccheri, S., Ottenhoff, T. H. M., Dieli, F., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01119 · Cited by 34

Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype

Lord, J. D., Long, S. A., Shows, D. M., Thorpe, J., Schwedhelm, K., Chen, J., Kita, M., & Buckner, J. H. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.05.006 · Cited by 35

T Cell Memory to Vaccination

Todryk, S. M. (2018) · Vaccines · doi:10.3390/vaccines6040084 · Cited by 35

The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions

Gong, X., Han, Z., Fan, H., Wu, Y., He, Y., Fu, Y., Zhu, T., & Li, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1238673 · Cited by 35

Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction

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Chemokine-Driven CD4 + T Cell Homing: New Concepts and Recent Advances

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A multivariate Th17 metagene for prognostic stratification in T cell non-inflamed triple negative breast cancer

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Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells

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Role of Co-stimulatory Molecules in T Helper Cell Differentiation

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A fresh look at the T helper subset dogma

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The dual role of IL-27 in CD4+T cells

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SARS-CoV-2 and Multiple Sclerosis: Potential for Disease Exacerbation

MacDougall, M., Sleiman, J. E.-H., Beauchemin, P., & Rangachari, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.871276 · Cited by 30

Differential effects of estradiol and progesterone on human T cell activation in vitro

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Could Sodium Chloride be an Environmental Trigger for Immune-Mediated Diseases? An Overview of the Experimental and Clinical Evidence

Toussirot, É., Béreau, M., Vauchy, C., & Saas, P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00440 · Cited by 28

Approaches in Immunotherapy, Regenerative Medicine, and Bioengineering for Type 1 Diabetes

Kopan, C., Tucker, T. R., Alexander, M., Mohammadi, M. R., Pone, E. J., & Lakey, J. R. T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01354 · Cited by 28

Contribution of Resident Memory CD8+ T Cells to Protective Immunity against Respiratory Syncytial Virus and Their Impact on Vaccine Design

Retamal-Díaz, A. R., Covián, C., Pacheco, G. A., Castiglione-Matamala, A. T., Bueno, S. M., González, P. A., & Kalergis, A. M. (2019) · Pathogens · doi:10.3390/pathogens8030147 · Cited by 28

The Concept of Pathogenic TH2 Cells: Collegium Internationale Allergologicum Update 2021

Bertschi, N., Bazzini, C., & Schlapbach, C. (2021) · International Archives of Allergy and Immunology · doi:10.1159/000515144 · Cited by 26

Characteristics of CD8+ and CD4+ Tissue-Resident Memory Lymphocytes in the Gastrointestinal Tract

Li, P., Zhang, Y., Xu, Y., Cao, H., & Li, L. (2022) · Advanced Gut & Microbiome Research · doi:10.1155/2022/9157455 · Cited by 28

The immunomodulatory potential of phage therapy to treat acne: a review on bacterial lysis and immunomodulation

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Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

Kasatskaya, S. A., Ladell, K., Egorov, E. S., Miners, K. L., Davydov, A. N., Metsger, M., Staroverov, D. B., Matveyshina, E. K., Shagina, I. A., Mamedov, I. Z., et al. (2020) · eLife · doi:10.7554/elife.57063 · Cited by 27

Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity

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STK4 Deficiency Impairs Innate Immunity and Interferon Production Through Negative Regulation of TBK1-IRF3 Signaling

Jørgensen, S. E., Al-Mousawi, A., Assing, K., Hartling, U. B., Grosen, D. W., Fisker, N., Nielsen, C., Jakobsen, M. A., & Mogensen, T. H. (2020) · Journal of Clinical Immunology · doi:10.1007/s10875-020-00891-7 · Cited by 25

Impact of gut microbiota on immune system

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Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination

Haks, M. C., Bottazzi, B., Cecchinato, V., Gregorio, C. D., Giudice, G. D., Kaufmann, S. H. E., Lanzavecchia, A., Lewis, D. J. M., Maertzdorf, J., Mantovani, A., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01563 · Cited by 26

Fingolimod Profoundly Reduces Frequencies and Alters Subset Composition of Circulating T Follicular Helper Cells in Multiple Sclerosis Patients

Huber, J. E., Chang, Y., Meinl, I., Kümpfel, T., Meinl, E., & Baumjohann, D. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900955 · Cited by 25

Peyer’s patch T H 17 cells are dispensable for gut IgA responses to oral immunization

Gribonika, I., Strömberg, A., Lebrero‐Fernández, C., Schön, K., Moon, J. J., Bemark, M., & Lycke, N. Y. (2022) · Science Immunology · doi:10.1126/sciimmunol.abc5500 · Cited by 24

The placental bed vascular pathology revisited: a risk indicator for cardiovascular disease

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Diverse functions of miR-17–92 cluster microRNAs in T helper cells

Baumjohann, D. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.02.035 · Cited by 24

Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-γ and IL-17 Production

Kushnareva, Y., Mathews, I. T., Andreyev, A. Y., Altay, G., Arlehamn, C. S. L., Vijayanand, P., Nilsson, R., Jain, M., Sette, A., Peters, B., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000672 · Cited by 23

Targeting Th17 cells in HIV-1 remission/cure interventions

Fert, A., Marchand, L. R., Salinas, T. R. W., & Ancuța, P. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.04.013 · Cited by 21

Magnolol Attenuates Concanavalin A‐induced Hepatic Fibrosis, Inhibits CD 4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling

Zhang, H., Ju, B., Zhang, X., Zhu, Y., Nie, Y., Xu, Y., & Lei, Q. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12749 · Cited by 23

Prospects for adoptive T-cell therapy for invasive fungal disease

Castellano-Gonzalez, G., Clancy, L. E., & Gottlieb, D. (2017) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000403 · Cited by 22

T-Cell Immune Responses to SARS-CoV-2 Infection and Vaccination

Notarbartolo, S. (2024) · Vaccines · doi:10.3390/vaccines12101126 · Cited by 23

Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation

Fernandes, R. A., Pérez‐Andrés, M., Blanco, E., Jara‐Acevedo, M., Criado, I., Almeida, J., Botafogo, V., Coutinho, I., Paiva, A. A., van Dongen, J. J. M., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02502 · Cited by 22

Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice

Rixon, J. A., Depew, C. E., & McSorley, S. J. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010333 · Cited by 22

Posttranscriptional Gene Regulation of T Follicular Helper Cells by RNA-Binding Proteins and microRNAs

Baumjohann, D., & Heissmeyer, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01794 · Cited by 23

Transcriptional profiling identifies caspase-1 as a T cell–intrinsic regulator of Th17 differentiation

Gao, Y., Deason, K. L., Jain, A., Irizarry-Caro, R. A., Dozmorov, I. M., Coughlin, L. A., Rauch, I., Evers, B. M., Koh, A. Y., Wakeland, E. K., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190476 · Cited by 22

Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype

Razzaghian, H. R., Sharafian, Z., Sharma, A., Boyce, G. K., Lee, K., Silva, R. D., Orban, P. C., Sékaly, R., Ross, C. J., & Lavoie, P. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.655027 · Cited by 20

Characteristics of and reference ranges for peripheral blood lymphocytes and CD4 + T cell subsets in healthy adults in Shanxi Province, North China

Xu, D., Wu, Y., Gao, C., Qin, Y., Zhao, X., Liang, Z., Wang, Y., Feng, M., Zhang, C., Liu, G., et al. (2020) · Journal of International Medical Research · doi:10.1177/0300060520913149 · Cited by 22

Immunological Aspects of Chronic Rhinosinusitis

Czerwaty, K., Piszczatowska, K., Brzost, J., Ludwig, N., Szczepański, M. J., & Dżaman, K. (2022) · Diagnostics · doi:10.3390/diagnostics12102361 · Cited by 21

Mucosal immunity and HIV acquisition in women

de Lara, L. M., Parthasarathy, R. S., & Rodríguez‐García, M. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.07.021 · Cited by 21

Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens?Preprint

Littman, D. R. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029355 · Cited by 22

Modeled vascular microenvironments: immune-endothelial cell interactions in vitro

Silberman, J., Jha, A., Ryan, H., Abbate, T., & Moore, E. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00970-1 · Cited by 20

Virus-like particles containing multiple antigenic proteins of Toxoplasma gondii induce memory T cell and B cell responses

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IL-12 drives the differentiation of human T follicular regulatory cells

Castaño, D., Wang, S. Y., Atencio-Garcia, S., Shields, E. J., Rico, M. C., Sharpe, H., Bustamante, J. C., Feng, A., Coz, C. L., Romberg, N. D., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adf2047 · Cited by 19

Prediction and Validation of Immunogenic Domains of Pneumococcal Proteins Recognized by Human CD4+T Cells

van de Garde, M. D. B., van Westen, E., Poelen, M. C. M., Rots, N. Y., & van Els, C. A. C. M. (2019) · Infection and Immunity · doi:10.1128/iai.00098-19 · Cited by 21

New Insights into Mechanisms of Long-term Protective Anti-tumor Immunity Induced by Cancer Vaccines Modified by Virus Infection

Schirrmacher, V. (2020) · Biomedicines · doi:10.3390/biomedicines8030055 · Cited by 19

T cell plasticity in renal autoimmune disease

Soukou, S., Huber, S., & Krebs, C. F. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03466-z · Cited by 19

Extracellular Vesicles: Schistosomal Long-Range Precise Weapon to Manipulate the Immune Response

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Critical Roles of SRC-3 in the Development and Progression of Breast Cancer, Rendering It a Prospective Clinical Target

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