The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Variations in MHC Class II Antigen Processing and Presentation in Health and Disease
Abstract
MHC class II (MHC-II) molecules are critical in the control of many immune responses. They are also involved in most autoimmune diseases and other pathologies. Here, we describe the biology of MHC-II and MHC-II variations that affect immune responses. We discuss the classic cell biology of MHC-II and various perturbations. Proteolysis is a major process in the biology of MHC-II, and we describe the various components forming and controlling this endosomal proteolytic machinery. This process ultimately determines the MHC-II–presented peptidome, including cryptic peptides, modified peptides, and other peptides that are relevant in autoimmune responses. MHC-II also variable in expression, glycosylation, and turnover. We illustrate that MHC-II is variable not only in amino acids (polymorphic) but also in its biology, with consequences for both health and disease.
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Metadata
- Authors
- Unanue, E. R., Turk, V., & Neefjes, J.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2016-05-20
- Volume
- 34
- Issue
- 1
- Pages
- 265-297
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W1884857780
- Cited by
- 270
- References
- 10
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
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