The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.
Control of Immunity by the Microbiota
Abstract
The immune system has coevolved with extensive microbial communities living on barrier sites that are collectively known as the microbiota. It is increasingly clear that microbial antigens and metabolites engage in a constant dialogue with the immune system, leading to microbiota-specific immune responses that occur in the absence of inflammation. This form of homeostatic immunity encompasses many arms of immunity, including B cell responses, innate-like T cells, and conventional T helper and T regulatory responses. In this review we summarize known examples of innate-like T cell and adaptive immunity to the microbiota, focusing on fundamental aspects of commensal immune recognition across different barrier sites. Furthermore, we explore how this cross talk is established during development, emphasizing critical temporal windows that establish long-term immune function. Finally, we highlight how dysregulation of immunity to the microbiota can lead to inflammation and disease, and we pinpoint outstanding questions and controversies regarding immune system–microbiota interactions.
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Cites
1 retracted
RETRACTED ARTICLE: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
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RetractedGut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
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Targeting the gut microbiota for cancer therapy
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Acne, Microbiome, and Probiotics: The Gut–Skin Axis
Sánchez-Pellicer, P., Navarro-Moratalla, L., Núñez-Delegido, E., Ruzafa-Costas, B., Agüera-Santos, J., & Navarro-López, V. (2022) · Microorganisms · doi:10.3390/microorganisms10071303 · Cited by 137
How microbiota improve immunotherapy
Ansaldo, E., & Belkaid, Y. (2021) · Science · doi:10.1126/science.abl3656 · Cited by 54
Self-citation
Metadata
- Authors
- Ansaldo, E., Farley, T. K., & Belkaid, Y.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2021-04-26
- Volume
- 39
- Issue
- 1
- Pages
- 449-479
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W3157204915
- Cited by
- 298
- References
- 201
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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