The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies
Abstract
Cancer cachexia is a complex metabolic condition characterized by loss of skeletal muscle. Common clinical manifestations include muscle wasting, anemia, reduced caloric intake, and altered immune function, which contribute to increased disability, fatigue, diminished quality of life, and reduced survival. The prevalence of cachexia and the impact of this disorder on the patient and family underscore the need for effective management strategies. Dietary supplementation and appetite stimulation alone are inadequate to reverse the underlying metabolic abnormalities of cancer cachexia and have limited long-term impact on patient quality of life and survival. Therapies that can increase muscle mass and physical performance may be a promising option; however, there are currently no drugs approved for the prevention or treatment of cancer cachexia. Several agents are in clinical development, including anabolic agents, such as selective androgen receptor modulators and drugs targeting inflammatory cytokines that promote skeletal muscle catabolism.
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“Tumour-induced inflammation can lead to increased production of tumour necrosis factor alpha, interleukin 6, interferon gamma, and other cytokines, which results in increased protein catabolism, decreased protein anabolism, insulin resistance, and lipolysis.115”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [115]
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Cites
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521
Prado, C. M., Lieffers, J. R., McCargar, L. J., Reiman, T., Sawyer, M. B., Martin, L., & Baracos, V. E. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70153-0 · Cited by 3,238
Self-citationJanssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Prognostic effect of weight loss prior tochemotherapy in cancer patients
DeWys, W. D., Begg, C. B., Lavin, P. T., Band, P. R., Bennett, J. M., Bertino, J. R., Cohen, M. H., Douglass, H. O., Engstrom, P. F., Ezdinli, E. Z., et al. (1980) · The American Journal of Medicine · doi:10.1016/s0149-2918(05)80001-3 · Cited by 2,350
Evans, W., Morley, J., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-zadeh, K., Lochs, H., Mantovani, G., et al. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.013 · Cited by 2,341
Self-citationAtrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251541198 · Cited by 1,774
Muscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732
(2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-79 · Cited by 1,506
Self-citationTisdale, M. J. (2009) · Physiological Reviews · doi:10.1152/physrev.00016.2008 · Cited by 1,216
Research works printed but not linked: 8
- Gullett N, 2009, J. Soc. Integr. Oncol., 7, 155
- Fearon KC, 1990, Infusionstherapie, 17, 63
- Tisdale MJ., 2005, J. Support. Oncol., 3, 209
- Tisdale MJ., 2003, J. Support. Oncol., 1, 159
- Jetté M., 1983, Guide for Anthropometric Measurements of Canadian Adults
- Tchekmedyian NS, 1995, Contemp. Oncol., 20, 30
- Cella D, 1993, Oncology, 7, 105
- Wiedenmann B, 2008, J. Support. Oncol., 6, 18
Cited by
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Items 301–318 of 318
Patel, J. R. (2020) · IP Journal of Nutrition Metabolism and Health Science · doi:10.18231/j.ijnmhs.2018.011
Palacio en Tabuk: Arquitecturas
Fathy, H. (1980) · Summarios
Macdonald, N. (2012) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199694143.003.0037
Hile, E. S., & Neuhold, R. (2022) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2022.02.012
Cancer Cachexia: A Glimpse Into a Neglected Aspect of Palliative Care in Sri Lanka
Darshana, N., Perera, S., Horadugoda, J., Silva, V. D., & Wijesinghe, C. J. (2023) · Asia Pacific Journal of Public Health · doi:10.1177/10105395231205754
Baracos, V. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-84702-5.00023-3
Self-citationRossini, C. V. T. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2023.tde-22112023-123324
Short-term muscle loss after gastrointestinal cancer surgery: A two-phase study
Xu, X. (2024) · Queensland University of Technology · doi:10.5204/thesis.eprints.250840
Lee, S., Choi, Y., Kim, Y., Cha, Y. K., Park, T. H., & Kim, Y. (2024) · Nutrition Research and Practice · doi:10.4162/nrp.2024.18.4.451
Neto, E. M. D. M. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2016.tde-16052017-135255
Zheng, C.-Y., Huang, X.-L., Ju, W., Qiu, X., Zu, B., Liu, H.-B., Xu, R., Chen, H.-H., & Lin, W. C. (2025) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2025.110450
Gomes, T. L. N., Borges, T. C., Ivo, J. F. M., Mainardi, L. G., Abadio, R. G. C., Wall, B. T., & Pimentel, G. D. (2025) · Pathophysiology · doi:10.3390/pathophysiology32040068
Ma, Z., Lin, Y., Zhang, B., Yue, P., Li, B., & Meng, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-30485-5
Dan, D. (2011) · The Knowledge Bank (The Ohio State University)
Role of p62/SQSTM1 in Statin Mediated Toxicity in Muscle Cells
Ramesh, M. (2014) · CSUN ScholarWorks (California State University, Northridge)
The Prognostic Impact of Sarcopenia in Stage I to III Colon Cancer A Retrospective StudyPreprint
Mi, C., Cui, F., Du, Y., Wang, S., She, Y., Li, Y., Wang, D., Wang, W., Dang, X., & Yang, H. (2025) · Research Square · doi:10.21203/rs.3.rs-8237628/v1
Implication des céramides dans l'atrophie musculaire
Larichaudy, J. D. (2012) · theses.fr (ABES) · doi:10.70675/b97ff403z6fa7z464fzb67czaa56e3753d9e
Bai, S., Fang, C., Zhang, X., Shi, Y., Tian, X., Yao, T., Zhang, Y., Ma, X., Chen, H., Cheng, Y., et al. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1740026
Metadata
- Authors
- Dodson, S., Baracos, V. E., Jatoi, A., Evans, W. J., Cella, D., Dalton, J. T., & Steiner, M. S.
- Affiliations
- GTx (United States) (US)
- University of Alberta (CA)
- Mayo Clinic (US)
- GlaxoSmithKline (United States) (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University (US)
- ORCID
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2011-02-18
- Volume
- 62
- Issue
- 1
- Pages
- 265-279
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2121063540
- Cited by
- 319
- References
- 83
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 22 · 2021: 22 · 2020: 23 · 2019: 17 · 2018: 21 · 2017: 19 · 2016: 19 · 2015: 26 · 2014: 31 · 2013: 19 · 2012: 34
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- cancer cachexia, muscle atrophy, skeletal muscle atrophy, anemia, energy intake, immune function, quality of life, survival, dietary supplementation, appetite stimulation, muscle mass, physical performance, anabolic agents, selective androgen receptor modulators, inflammatory cytokines, skeletal muscle catabolism, cachexia treatment
- MeSH terms
- Cachexia, Clinical Trials as Topic, Energy Metabolism, Female, Humans, Male, Muscular Atrophy, Neoplasms, Quality of Life, Cytokines, Muscle, Skeletal, Anabolic Agents
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