Cited by 319Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

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Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies

Dodson, Shontelle, Baracos, Vickie E., Jatoi, Aminah, Evans, William J., Cella, David, Dalton, James T., Steiner, Mitchell S.·2011·Annual Review of Medicine

DOI 10.1146/annurev-med-061509-131248

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Abstract

Cancer cachexia is a complex metabolic condition characterized by loss of skeletal muscle. Common clinical manifestations include muscle wasting, anemia, reduced caloric intake, and altered immune function, which contribute to increased disability, fatigue, diminished quality of life, and reduced survival. The prevalence of cachexia and the impact of this disorder on the patient and family underscore the need for effective management strategies. Dietary supplementation and appetite stimulation alone are inadequate to reverse the underlying metabolic abnormalities of cancer cachexia and have limited long-term impact on patient quality of life and survival. Therapies that can increase muscle mass and physical performance may be a promising option; however, there are currently no drugs approved for the prevention or treatment of cancer cachexia. Several agents are in clinical development, including anabolic agents, such as selective androgen receptor modulators and drugs targeting inflammatory cytokines that promote skeletal muscle catabolism.

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Authors: Dodson, S., Baracos, V. E., Jatoi, A., Evans, W. J., Cella, D., Dalton, J. T., & Steiner, M. S.
Affiliations: GTx (United States) (US)
University of Alberta (CA)
Mayo Clinic (US)
GlaxoSmithKline (United States) (US)
Robert H. Lurie Comprehensive Cancer Center of Northwestern University (US)
ORCID: Baracos, Vickie E.
Jatoi, Aminah
Evans, William J.
Cella, David
Dalton, James T.
Steiner, Mitchell S.
Venue: Annual Review of Medicine
Publisher: Annual Reviews
Published: 2011-02-18
Volume: 62
Issue: 1
Pages: 265-279
ISSN: 0066-4219 (ISSN-L)
1545-326X
DOI: 10.1146/annurev-med-061509-131248
OpenAlex: W2121063540
Cited by: 319
References: 83
Citations by year: 2026: 2 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 22 · 2021: 22 · 2020: 23 · 2019: 17 · 2018: 21 · 2017: 19 · 2016: 19 · 2015: 26 · 2014: 31 · 2013: 19 · 2012: 34
FWCI: 2.17
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: cancer cachexia, muscle atrophy, skeletal muscle atrophy, anemia, energy intake, immune function, quality of life, survival, dietary supplementation, appetite stimulation, muscle mass, physical performance, anabolic agents, selective androgen receptor modulators, inflammatory cytokines, skeletal muscle catabolism, cachexia treatment
MeSH terms: Cachexia, Clinical Trials as Topic, Energy Metabolism, Female, Humans, Male, Muscular Atrophy, Neoplasms, Quality of Life, Cytokines, Muscle, Skeletal, Anabolic Agents

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Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies

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