Cited by 319Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

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Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies

Dodson, Shontelle, Baracos, Vickie E., Jatoi, Aminah, Evans, William J., Cella, David, Dalton, James T., Steiner, Mitchell S.·2011·Annual Review of Medicine

DOI 10.1146/annurev-med-061509-131248

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Abstract

Cancer cachexia is a complex metabolic condition characterized by loss of skeletal muscle. Common clinical manifestations include muscle wasting, anemia, reduced caloric intake, and altered immune function, which contribute to increased disability, fatigue, diminished quality of life, and reduced survival. The prevalence of cachexia and the impact of this disorder on the patient and family underscore the need for effective management strategies. Dietary supplementation and appetite stimulation alone are inadequate to reverse the underlying metabolic abnormalities of cancer cachexia and have limited long-term impact on patient quality of life and survival. Therapies that can increase muscle mass and physical performance may be a promising option; however, there are currently no drugs approved for the prevention or treatment of cancer cachexia. Several agents are in clinical development, including anabolic agents, such as selective androgen receptor modulators and drugs targeting inflammatory cytokines that promote skeletal muscle catabolism.

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Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521
Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study
Prado, C. M., Lieffers, J. R., McCargar, L. J., Reiman, T., Sawyer, M. B., Martin, L., & Baracos, V. E. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70153-0 · Cited by 3,238
Self-citation
Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Prognostic effect of weight loss prior tochemotherapy in cancer patients
DeWys, W. D., Begg, C. B., Lavin, P. T., Band, P. R., Bennett, J. M., Bertino, J. R., Cohen, M. H., Douglass, H. O., Engstrom, P. F., Ezdinli, E. Z., et al. (1980) · The American Journal of Medicine · doi:10.1016/s0149-2918(05)80001-3 · Cited by 2,350
Cachexia: a new definition.
Evans, W., Morley, J., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-zadeh, K., Lochs, H., Mantovani, G., et al. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.013 · Cited by 2,341
Self-citation
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251541198 · Cited by 1,774
Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”
Muscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732
The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation.
(2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-79 · Cited by 1,506
Self-citation
Mechanisms of Cancer Cachexia
Tisdale, M. J. (2009) · Physiological Reviews · doi:10.1152/physrev.00016.2008 · Cited by 1,216
Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment
Prado, C. M. M., Baracos, V. E., McCargar, L. J., Reiman, T., Mourtzakis, M., Tonkin, K. S., Mackey, J. R., Koski, S. L., Pituskin, E., & Sawyer, M. B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2242 · Cited by 1,125
Self-citation
Skeletal muscle hypertrophy and atrophy signaling pathways
Glass, D. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.018 · Cited by 1,106 · cited 1×
“It is important to note that despite compelling data implicating inflammatory cytokines as key mediators of cancer cachexia and muscle atrophy (9, 23, 25, 79), clinical trials to date have not consistently shown that inhibition of a single, specific cytokine leads to the reversal or attenuation of this disorder (20, 5…”
Sarcopenia
Morley, J. E., Baumgartner, R., Roubenoff, R., Mayer, J., & Nair, K. S. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.113504 · Cited by 964
Sarcopenic obesity: A new category of obesity in the elderly
Zamboni, M., Mazzali, G., Fantin, F., Rossi, A., & Di Francesco, V. (2008) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.10.002 · Cited by 953
Cachexia: pathophysiology and clinical relevance1,2
Morley, J. E., Thomas, D. R., & Wilson, M.-M. G. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.735 · Cited by 786
Skeletal muscle loss: cachexia, sarcopenia, and inactivity
Evans, W. J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608a · Cited by 758
Self-citation
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
Glass, D. J. (2003) · Nature Cell Biology · doi:10.1038/ncb0203-87 · Cited by 694
Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity
Prado, C. M. M., Baracos, V. E., McCargar, L. J., Mourtzakis, M., Mulder, K. E., Reiman, T., Butts, C. A., Scarfe, A. G., & Sawyer, M. B. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3067 · Cited by 621
Self-citation
Mechanisms of Cancer-Related Fatigue
Ryan, J. L., Carroll, J. K., Ryan, E. P., Mustian, K. M., Fiscella, K. A., & Morrow, G. R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-s1-22 · Cited by 599
Epidemiology of Sarcopenia
III, L. J. M., Khosla, S., Crowson, C. S., O'Connor, M. K., O'Fallon, W. M., & Riggs, B. L. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04719.x · Cited by 598
Nutrition Support in Clinical Practice: Review of Published Data and Recommendations for Future Research Directions
Klein, S., Kinney, J. M., Jeejeebhoy, K. N., Alpers, D., Hellerstein, M. K., Murray, M. J., & Twomey, P. L. (1997) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607197021003133 · Cited by 561
Tumour immunity: effector response to tumour and role of the microenvironment
Mantovani, A., Romero, P. J., Palucka, A. K., & Marincola, F. M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60241-x · Cited by 539
Chemistry and Structural Biology of Androgen Receptor
Gao, W., Bohl, C. E., & Dalton, J. T. (2005) · Chemical Reviews · doi:10.1021/cr020456u · Cited by 527
Self-citation
Body composition in patients with non−small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis
Baracos, V. E., Reiman, T., Mourtzakis, M., Gioulbasanis, I., & Antoun, S. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608c · Cited by 504
Self-citation
Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma
Antoun, S., Baracos, V. E., Birdsell, L., Escudier, B. J., & Sawyer, M. B. (2010) · Annals of Oncology · doi:10.1093/annonc/mdp605 · Cited by 430
Self-citation
Standardizing Patient-Reported Outcomes Assessment in Cancer Clinical Trials: A Patient-Reported Outcomes Measurement Information System Initiative
Garcia, S. F., Cella, D., Clauser, S. B., Flynn, K. E., Lad, T., Lai, J.-S., Reeve, B. B., Wilder Smith, A., Stone, A. A., & Weinfurt, K. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.2341 · Cited by 407
Self-citation
Signaling pathways perturbing muscle mass.
Glass, D. J. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833862df · Cited by 359
Randomized Comparison of Megestrol Acetate Versus Dexamethasone Versus Fluoxymesterone for the Treatment of Cancer Anorexia/Cachexia
Loprinzi, C. L., Kugler, J. W., Sloan, J. A., Mailliard, J. A., Krook, J. E., Wilwerding, M. B., Rowland, K. M., Camoriano, J. K., Novotny, P. J., & Christensen, B. J. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.10.3299 · Cited by 341
Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial
Gordon, J., Trebble, T. M., Ellis, R. D., Duncan, H. D., Johns, T., & Goggin, P. M. (2005) · Gut · doi:10.1136/gut.2004.047563 · Cited by 322
ABC of palliative care: Anorexia, cachexia, and nutrition
Bruera, E. D. (1997) · BMJ · doi:10.1136/bmj.315.7117.1219 · Cited by 312
Drug Insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging
Bhasin, S., Calof, O. M., Storer, T. W., Lee, M. L., Mazer, N. A., Jasuja, R., Montori, V. M., Gao, W., & Dalton, J. T. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0120 · Cited by 298
Self-citation
Sarcopenia in elderly men and women
Castillo, E. M., Goodman-Gruen, D., Kritz-Silverstein, D., Morton, D. J., Wingard, D. L., & Barrett-Connor, E. (2003) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(03)00197-1 · Cited by 290
The emerging role of computerized tomography in assessing cancer cachexia
Prado, C. M. M., Birdsell, L., & Baracos, V. E. (2009) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328331124a · Cited by 283
Self-citation
Cachexia: prevalence and impact in medicine
Tan, B. H. L., & Fearon, K. C. H. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328300ecc1 · Cited by 266
Nutrition support in clinical practice: review of published data and recommendations for future research directions. Summary of a conference sponsored by the National Institutes of Health, American Society for Parenteral and Enteral Nutrition, and American Society for Clinical Nutrition
Klein, S., Kinney, J., Jeejeebhoy, K. N., Alpers, D., Hellerstein, M. K., Murray, M. J., & Twomey, P. L. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.3.683 · Cited by 256
Prevention and treatment of cancer cachexia: New insights into an old problem
Muscaritoli, M., Bossola, M., Aversa, Z., Bellantone, R. D. A., & Fanelli, F. R. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.07.026 · Cited by 241
Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia
Mantovani, G., Macciò, A., Madeddu, C., Serpe, R., Massa, E., Dessì, M., Panzone, F., & Contu, P. (2010) · The Oncologist · doi:10.1634/theoncologist.2009-0153 · Cited by 231
Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia.
Loprinzi, C. L., Michalak, J. C., Schaid, D. J., Mailliard, J. A., Athmann, L. M., Goldberg, R. M., Tschetter, L. K., Hatfield, A. K., & Morton, R. F. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.4.762 · Cited by 223
Anabolic-Androgenic Steroid Therapy in the Treatment of Chronic Diseases
Basaria, S. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.11.5108 · Cited by 223
Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)
Gao, W., & Dalton, J. T. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.01.003 · Cited by 217
Self-citation
Understanding and Managing Cancer Cachexia
Macdonald, N., Easson, A. M., Mazurak, V. C., Dunn, G. P., & Baracos, V. E. (2003) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(03)00382-x · Cited by 209
Self-citation
Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit
Mohler, M. L., Bohl, C. E., Jones, A. J., Coss, C. C., Narayanan, R., He, Y., Hwang, D., Dalton, J. T., & Miller, D. D. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900280m · Cited by 207
Self-citation
Re-validation and Shortening of the Functional Assessmentof Anorexia/Cachexia Therapy (FAACT) Questionnaire
Ribaudo, J. M., Cella, D. F., Hahn, E. A., Lloyd, S. R., Tchekmedyian, N. S., Roenn, J. V., & Leslie, W. T. (2000) · Quality of Life Research · doi:10.1023/a:1016670403148 · Cited by 205
Self-citation
Pentoxifylline for treatment of cancer anorexia and cachexia? A randomized, double-blind, placebo-controlled trial.
Goldberg, R. M., Loprinzi, C. L., Mailliard, J. A., O'Fallon, J. R., Krook, J. E., Ghosh, C., Hestorff, R., Chong, S. F., Reuter, N. F., & Shanahan, T. G. (1995) · Journal of Clinical Oncology · doi:10.1200/jco.1995.13.11.2856 · Cited by 184
Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia
Argilés, J. M. A., Busquets, S., Felipe, A., & López-Soriano, F. J. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.003 · Cited by 177
Cancer-Associated Cachexia and Underlying Biological Mechanisms
Baracos, V. E. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111151 · Cited by 177
Self-citation
Selective androgen receptor modulators in preclinical and clinical development
Narayanan, R., Mohler, M. L., Bohl, C. E., Miller, D. D., & Dalton, J. T. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06010 · Cited by 159
Self-citation
The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting.
Tisdale, M. J. (2005) · PubMed · Cited by 145
A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia.
Wiedenmann, B., Malfertheiner, P., Friess, H., Ritch, P. S., Arseneau, J. C., Mantovani, G., Caprioni, F., Cutsem, E. V., Richel, D. J., DeWitte, M., et al. (2008) · PubMed · Cited by 144
Pathogenesis of cancer cachexia.
Tisdale, M. J. (2004) · PubMed · Cited by 140
Fatigue management
Mock, V. (2001) · Cancer · doi:10.1002/1097-0142(20010915)92:6+ · Cited by 140
The experience of cancer cachexia: A qualitative study of advanced cancer patients and their family members
Reid, J., McKenna, H., Fitzsimons, D., & McCance, T. (2008) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2008.10.012 · Cited by 140
Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia
Mantovani, G., Macciò, A., Madeddu, C., Serpe, R., Antoni, G., Massa, E., Dessì, M., & Panzone, F. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0547-z · Cited by 135
Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis
Klaude, M., Fredriksson, K., Tjäder, I., Hammarqvist, F., Ahlman, B. H. J., Rooyackers, O., & Wernerman, J. (2007) · Clinical Science · doi:10.1042/cs20060265 · Cited by 126
Appendicular lean tissue mass and the prevalence of sarcopenia among healthy women
Tank[oacute], L. B., Movsesyan, L., Mouritzen, U., Christiansen, C., & Svendsen, O. L. (2002) · Metabolism · doi:10.1053/meta.2002.28960 · Cited by 121
Regulation of Protein Catabolism by Muscle-Specific and Cytokine-Inducible Ubiquitin Ligase E3α-II during Cancer Cachexia
Kwak, K. S., Zhou, X., Solomon, V., Baracos, V. E., Davis, J. G., Bannon, A. W., Boyle, W. J., Lacey, D. L., & Han, H. Q. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2102 · Cited by 112
Self-citation
Effects of medroxyprogesterone acetate on food intake, body composition, and resting energy expenditure in patients with advanced, nonhormone-sensitive cancer
Simons, J., Schols, A. M. W. J., Hoefnagels, J. M. J., Westerterp, K. R., ten Velde, G. P. M., & Wouters, E. F. �. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980201)82:3 · Cited by 112
Excess Mortality Following Vertebral Fracture
Melton, L. J. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb02658.x · Cited by 112
The impact of hypogonadism and autonomic dysfunction on fatigue, emotional function, and sexual desire in male patients with advanced cancer: A pilot study
Strasser, F., Palmer, J. L., Schover, L. R., Yusuf, S. W., Pisters, K., Vassilopoulou‐Sellin, R., DeGracia, B., Willey, J. S., & Bruera, E. (2006) · Cancer · doi:10.1002/cncr.22339 · Cited by 112
Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands
Gao, W., Kim, J., & Dalton, J. T. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9024-3 · Cited by 109
Self-citation
Cancer cachexia
Gordon, J., Green, S. R., & Goggin, P. M. (2005) · QJM · doi:10.1093/qjmed/hci127 · Cited by 107
An exploration of the experience of cancer cachexia: what patients and their families want from healthcare professionals
Reid, J., McKenna, H., Fitzsimons, D., & CANCE, T. V. M. (2009) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2009.01124.x · Cited by 103
Oesophageal cancer and cachexia: the effect of short‐term treatment with thalidomide on weight loss and lean body mass
Khan, Z. H., Simpson, E. J., COLE, A. T., Holt, M., Macdonald, I. A., Pye, D., Austin, A., & Freeman, J. G. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01457.x · Cited by 98
Adult malnutrition: simple assessment techniques for use in emergencies
Ferro-Luzzi, A., & James, W. P. T. (1996) · British Journal Of Nutrition · doi:10.1079/bjn19960105 · Cited by 92
Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers
Garcia, J. M., & Polvino, W. J. (2009) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.12.003 · Cited by 89
Cancer cachexia: medical management
Mantovani, G., & Madeddu, C. (2009) · Supportive Care in Cancer · doi:10.1007/s00520-009-0722-3 · Cited by 81
Body composition in French women 75+ years of age: The EPIDOS study
Guyonnet, S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00198-7 · Cited by 73
MAFbx/Atrogin-1 expression is a poor index of muscle proteolysis
Attaix, D., & Baracos, V. E. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328338b9a6 · Cited by 73
Self-citation
Cancer Anorexia-Cachexia Syndrome
McClement, S. (2005) · Journal of Wound Ostomy and Continence Nursing · doi:10.1097/00152192-200507000-00012 · Cited by 67
Body Composition in Cancer Cachexia
Fearon, K. C. H., & Preston, T. (1990) · Transfusion Medicine and Hemotherapy · doi:10.1159/000222558 · Cited by 67
A phase II randomized, placebo-controlled, double-blind study of the efficacy and safety of RC-1291 (RC) for the treatment of cancer cachexia
Garcia, J. M., Boccia, R. V., Graham, C., Kumor, K. M., & Polvino, W. J. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.9133 · Cited by 52
Update on emerging drugs for cancer cachexia
Murphy, K. T., & Lynch, G. S. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210903369351 · Cited by 48
Nonsteroidal Selective Androgen Receptor Modulator Ostarine ™ in Cancer Cachexia
Zilbermint, M. F., & Dobs, A. S. (2009) · Future Oncology · doi:10.2217/fon.09.106 · Cited by 45
Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery
Segal, S., Narayanan, R., & Dalton, J. T. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.4.377 · Cited by 43
Self-citation
Cancer-induced cachexia: a guide for the oncologist.
Gullett, N. P., Rossi, P. J., Kucuk, O., & Johnstone, P. A. S. (2009) · PubMed · Cited by 39
Pharmacological options for advanced cancer patients with loss of appetite and weight
Behl, D., & Jatoi, A. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.8.1085 · Cited by 34
Self-citation
A phase III randomized study comparing the effects of oxandrolone (Ox) and megestrol acetate (Meg) on lean body mass (LBM), weight (wt) and quality of life (QOL) in patients with solid tumors and weight loss receiving chemotherapy
Lesser, G. J., Case, D., Ottery, F. D., McQuellon, R. P., Choksi, J. K., Sanders, G., Rosdhal, R., & Shaw, E. G. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.9513 · Cited by 21
Megestrol Acetate Use for Weight Gain Should Be Carefully Considered
Evans, W. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2734 · Cited by 21
Self-citation
Ostarine increases lean body mass and improves physical performance in healthy elderly subjects: Implications for cancer cachexia patients
Evans, W. J., Smith, M. R., Morley, J. E., Barnette, K. G., Rodriguez, D., Steiner, M. S., & Dalton, J. T. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.9119 · Cited by 19
Self-citation
Nos expériences cliniques avec un nouvel alcaloyde extrait du Colchicum autumnale
Gf, G. (2009) · Oncologia · doi:10.1159/000223715 · Cited by 13
Molecular signatures characterize early stage breast cancer arising in young women and have prognostic and therapeutic implications independent of ER status
Anders, C. K., Hsu, S. D., Acharya, C. R., Zhang, Y., Wang, Y., Foekens, J. A., Marcom, P. K., Marks, J. R., Nevins, J. R., Potti, A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.522 · Cited by 5
Megestrol Acetate Oral Suspension
Porche, D. J. (2021) · doi:10.31003/uspnf_m48054_01_01 · Cited by 2
Untitled work
Wajchenberg (2000) · doi:10.1002/(sici)1097-0142(20000215)88:4

Research works printed but not linked: 8

Gullett N, 2009, J. Soc. Integr. Oncol., 7, 155
Fearon KC, 1990, Infusionstherapie, 17, 63
Tisdale MJ., 2005, J. Support. Oncol., 3, 209
Tisdale MJ., 2003, J. Support. Oncol., 1, 159
Jetté M., 1983, Guide for Anthropometric Measurements of Canadian Adults
Tchekmedyian NS, 1995, Contemp. Oncol., 20, 30
Cella D, 1993, Oncology, 7, 105
Wiedenmann B, 2008, J. Support. Oncol., 6, 18

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See all 319

Authors: Dodson, S., Baracos, V. E., Jatoi, A., Evans, W. J., Cella, D., Dalton, J. T., & Steiner, M. S.
Affiliations: GTx (United States) (US)
University of Alberta (CA)
Mayo Clinic (US)
GlaxoSmithKline (United States) (US)
Robert H. Lurie Comprehensive Cancer Center of Northwestern University (US)
ORCID: Baracos, Vickie E.
Jatoi, Aminah
Evans, William J.
Cella, David
Dalton, James T.
Steiner, Mitchell S.
Venue: Annual Review of Medicine
Publisher: Annual Reviews
Published: 2011-02-18
Volume: 62
Issue: 1
Pages: 265-279
ISSN: 0066-4219 (ISSN-L)
1545-326X
DOI: 10.1146/annurev-med-061509-131248
OpenAlex: W2121063540
Cited by: 319
References: 83
Citations by year: 2026: 2 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 22 · 2021: 22 · 2020: 23 · 2019: 17 · 2018: 21 · 2017: 19 · 2016: 19 · 2015: 26 · 2014: 31 · 2013: 19 · 2012: 34
FWCI: 2.17
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: cancer cachexia, muscle atrophy, skeletal muscle atrophy, anemia, energy intake, immune function, quality of life, survival, dietary supplementation, appetite stimulation, muscle mass, physical performance, anabolic agents, selective androgen receptor modulators, inflammatory cytokines, skeletal muscle catabolism, cachexia treatment
MeSH terms: Cachexia, Clinical Trials as Topic, Energy Metabolism, Female, Humans, Male, Muscular Atrophy, Neoplasms, Quality of Life, Cytokines, Muscle, Skeletal, Anabolic Agents

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Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies

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