The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies
Abstract
Cancer cachexia is a complex metabolic condition characterized by loss of skeletal muscle. Common clinical manifestations include muscle wasting, anemia, reduced caloric intake, and altered immune function, which contribute to increased disability, fatigue, diminished quality of life, and reduced survival. The prevalence of cachexia and the impact of this disorder on the patient and family underscore the need for effective management strategies. Dietary supplementation and appetite stimulation alone are inadequate to reverse the underlying metabolic abnormalities of cancer cachexia and have limited long-term impact on patient quality of life and survival. Therapies that can increase muscle mass and physical performance may be a promising option; however, there are currently no drugs approved for the prevention or treatment of cancer cachexia. Several agents are in clinical development, including anabolic agents, such as selective androgen receptor modulators and drugs targeting inflammatory cytokines that promote skeletal muscle catabolism.
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“Tumour-induced inflammation can lead to increased production of tumour necrosis factor alpha, interleukin 6, interferon gamma, and other cytokines, which results in increased protein catabolism, decreased protein anabolism, insulin resistance, and lipolysis.115”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [115]
Citations
Cites
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Cited by
Sorted by citations
Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases
Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70034-8 · Cited by 1,102
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Metadata
- Authors
- Dodson, S., Baracos, V. E., Jatoi, A., Evans, W. J., Cella, D., Dalton, J. T., & Steiner, M. S.
- Affiliations
- GTx (United States) (US)
- University of Alberta (CA)
- Mayo Clinic (US)
- GlaxoSmithKline (United States) (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University (US)
- ORCID
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2011-02-18
- Volume
- 62
- Issue
- 1
- Pages
- 265-279
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2121063540
- Cited by
- 319
- References
- 83
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 22 · 2021: 22 · 2020: 23 · 2019: 17 · 2018: 21 · 2017: 19 · 2016: 19 · 2015: 26 · 2014: 31 · 2013: 19 · 2012: 34
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- cancer cachexia, muscle atrophy, skeletal muscle atrophy, anemia, energy intake, immune function, quality of life, survival, dietary supplementation, appetite stimulation, muscle mass, physical performance, anabolic agents, selective androgen receptor modulators, inflammatory cytokines, skeletal muscle catabolism, cachexia treatment
- MeSH terms
- Cachexia, Clinical Trials as Topic, Energy Metabolism, Female, Humans, Male, Muscular Atrophy, Neoplasms, Quality of Life, Cytokines, Muscle, Skeletal, Anabolic Agents
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