The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Mechanisms of Bacterial Colonization of the Respiratory Tract
Open accessAbstract
Respiratory tract infections are an important cause of morbidity and mortality worldwide. Chief among these are infections involving the lower airways. The opportunistic bacterial pathogens responsible for most cases of pneumonia can cause a range of local and invasive infections. However, bacterial colonization (or carriage) in the upper airway is the prerequisite of all these infections. Successful colonizers must attach to the epithelial lining, grow on the nutrient-limited mucosal surface, evade the host immune response, and transmit to a susceptible host. Here, we review the molecular mechanisms underlying these conserved stages of carriage. We also examine how the demands of colonization influence progression to disease. A range of bacteria can colonize the upper airway; nevertheless, we focus on strategies shared by many respiratory tract opportunistic pathogens. Understanding colonization opens a window to the evolutionary pressures these pathogens face within their animal hosts and that have selected for attributes that contribute to virulence and pathogenesis.
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Nasal Carriage as a Source of Staphylococcus aureus Bacteremia
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Streptococcus pneumoniae colonisation: the key to pneumococcal disease
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“Common to all these pathogens, as well as other opportunistic invaders of the respiratory tract, is the requirement for asymptomatic bacterial colonization, or carriage, to precede local and systemic disease (9, 31, 120).”
BackgroundIwase, T., Uehara, Y., Shinji, H., Tajima, A., Seo, H., Takada, K., Agata, T., & Mizunoe, Y. (2010) · Nature · doi:10.1038/nature09074 · Cited by 991
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“aureus (74), the two most common pathogens of postinfluenza disease, after pneumococci (69).”
BackgroundInfluentialWarfel, J. M., Zimmerman, L. I., & Merkel, T. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314688110 · Cited by 644
Iron availability and infection
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A Molecular Mechanism for Bacterial Susceptibility to Zinc
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Cited by
Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter
Davies, J. S., Currie, M. J., North, R. A., Scalise, M., Wright, J. D., Copping, J. M., Remus, D. M., Gulati, A., Morado, D. R., Jamieson, S. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36590-1 · Cited by 34
Metadata
- Authors
- Siegel, S. J., & Weiser, J. N.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2015-10-15
- Volume
- 69
- Issue
- 1
- Pages
- 425-444
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2140748662
- Cited by
- 211
- References
- 16
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Siegel, S. J., & Weiser, J. N. (2015). Mechanisms of Bacterial Colonization of the Respiratory Tract. Annual Review of Microbiology. https://doi.org/10.1146/annurev-micro-091014-104209
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
