The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Lipoteichoic Acid Synthesis and Function in Gram-Positive Bacteria
Open accessAbstract
Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria. Although the exact role of LTA is unknown, mutants display significant growth and physiological defects. Additionally, modification of the LTA backbone structure can provide protection against cationic antimicrobial peptides. This review provides an overview of the different LTA types and their chemical structures and synthesis pathways. The occurrence and mechanisms of LTA modifications with d-alanyl, glycosyl, and phosphocholine residues will be discussed along with their functions. Similarities between the production of type I LTA and osmoregulated periplasmic glucans in gram-negative bacteria are highlighted, indicating that LTA should perhaps be compared to these polymers rather than lipopolysaccharide, as is presently the case. Lastly, current efforts to use LTAs as vaccine candidates, synthesis proteins as novel antimicrobial targets, and LTA mutant strains as improved probiotics are highlighted.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling
Hofmann, K. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01539-x · Cited by 495
Cited by
Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides
Malanovic, N., & Lohner, K. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.11.004 · Cited by 586
Antimicrobial Peptides Targeting Gram-Positive Bacteria
Malanovic, N., & Lohner, K. (2016) · Pharmaceuticals · doi:10.3390/ph9030059 · Cited by 420
The Gram-Positive Bacterial Cell Wall
Rohde, M. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0044-2018 · Cited by 319
The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies
Liu, D., Van Belleghem, J. D., de Vries, C. R., Burgener, E., Chen, Q., Manasherob, R., Aronson, J. R., Amanatullah, D. F., Tamma, P. D., & Suh, G. A. (2021) · Viruses · doi:10.3390/v13071268 · Cited by 268
Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila
Becken, B., Davey, L., Middleton, D. R., Mueller, K. D., Sharma, A., Holmes, Z. C., Dallow, E., Remick, B., Barton, G. M., David, L. A., et al. (2021) · mBio · doi:10.1128/mbio.00478-21 · Cited by 125
Metadata
- Authors
- Percy, M. G., & Gründling, A.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2014-09-08
- Volume
- 68
- Issue
- 1
- Pages
- 81-100
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2105719418
- Cited by
- 461
- References
- 1
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Lipoteichoic Acid Synthesis and Function in Gram-Positive Bacteria. https://app.cochat.ai/papers/10.1146/annurev-micro-091213-112949
- The paper
- Percy, M. G., & Gründling, A. (2014). Lipoteichoic Acid Synthesis and Function in Gram-Positive Bacteria. Annual Review of Microbiology. https://doi.org/10.1146/annurev-micro-091213-112949
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
