The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis
Open accessAbstract
Citrus flavonoids are polyphenolic compounds with significant biological properties. This review summarizes recent advances in understanding the ability of citrus flavonoids to modulate lipid metabolism, other metabolic parameters related to the metabolic syndrome, and atherosclerosis. Citrus flavonoids, including naringenin, hesperitin, nobiletin, and tangeretin, have emerged as potential therapeutics for the treatment of metabolic dysregulation. Epidemiological studies reveal an association between the intake of citrus flavonoid–containing foods and a decreased incidence of cardiovascular disease. Studies in cell culture and animal models, as well as a limited number of clinical studies, reveal the lipid-lowering, insulin-sensitizing, antihypertensive, and anti-inflammatory properties of citrus flavonoids. In animal models, supplementation of rodent diets with citrus flavonoids prevents hepatic steatosis, dyslipidemia, and insulin resistance primarily through inhibition of hepatic fatty acid synthesis and increased fatty acid oxidation. Citrus flavonoids blunt the inflammatory response in metabolically important tissues including liver, adipose, kidney, and the aorta. The mechanisms underlying flavonoid-induced metabolic regulation have not been completely established, although several potential targets have been identified. In mouse models, citrus flavonoids show marked suppression of atherogenesis through improved metabolic parameters as well as through direct impact on the vessel wall. Recent studies support a role for citrus flavonoids in the treatment of dyslipidemia, insulin resistance, hepatic steatosis, obesity, and atherosclerosis. Larger human studies examining dose, bioavailability, efficacy, and safety are required to promote the development of these promising therapeutic agents.
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“In a randomized, double-blind study with 24 healthy adults, 1.2 g of oral ginger accelerated gastric emptying (half-emptying time after a meal 13 min vs. 27 min with placebo), and increased gastric antral contractions without adverse symptoms [350].”
From Nutritional Approaches to Enhance GLP-1 Analogue Therapy in Obesity: A Narrative Review (2025) · cites this paper as [350]
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“In a randomized, double-blind study with 24 healthy adults, 1.2 g of oral ginger accelerated gastric emptying (half-emptying time after a meal 13 min vs. 27 min with placebo), and increased gastric antral contractions without adverse symptoms [350].”
From Nutritional Approaches to Enhance GLP-1 Analogue Therapy in Obesity: A Narrative Review (2025) · cites this paper as [350]
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Circadian rhythm as a therapeutic target
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Metadata
- Authors
- Mulvihill, E. E., Burke, A. C., & Huff, M. W.
- Affiliations
- Western University (CA)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2016-07-17
- Volume
- 36
- Issue
- 1
- Pages
- 275-299
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2211999579
- Cited by
- 228
- References
- 100
- Citations by year
- 2026: 20 · 2025: 15 · 2024: 24 · 2023: 19 · 2022: 26 · 2021: 31 · 2020: 38 · 2019: 25 · 2018: 17 · 2017: 9 · 2016: 4
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada (G-14-0006179)
- Canadian Institutes of Health Research (T-7007)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Bioactive Compounds in Plants
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Keywords
- citrus flavonoids, naringenin, hesperidin, nobiletin, tangeretin, lipoprotein metabolism, atherosclerosis, metabolic syndrome, dyslipidemia, insulin resistance, hepatic steatosis, hepatic fatty acid synthesis, fatty acid oxidation, anti-inflammatory activity, antihypertensive effect, cardiovascular disease prevention, obesity
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Hypolipidemic Agents, Antioxidants, Citrus, Diabetes Mellitus, Type 2, Flavonoids, Humans, Hyperlipidemias, Insulin Resistance, Lipoproteins, Risk Factors, Anti-Obesity Agents, Dietary Supplements, Overweight, Atherosclerosis, Non-alcoholic Fatty Liver Disease
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