Cited by 228Bioactive Compounds in PlantsPhytochemicals and Antioxidant ActivitiesFlavonoids in Medical Research

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Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis

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Mulvihill, Erin E., Burke, Amy C., Huff, Murray W.·2016·Annual Review of Nutrition

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Abstract

Citrus flavonoids are polyphenolic compounds with significant biological properties. This review summarizes recent advances in understanding the ability of citrus flavonoids to modulate lipid metabolism, other metabolic parameters related to the metabolic syndrome, and atherosclerosis. Citrus flavonoids, including naringenin, hesperitin, nobiletin, and tangeretin, have emerged as potential therapeutics for the treatment of metabolic dysregulation. Epidemiological studies reveal an association between the intake of citrus flavonoid–containing foods and a decreased incidence of cardiovascular disease. Studies in cell culture and animal models, as well as a limited number of clinical studies, reveal the lipid-lowering, insulin-sensitizing, antihypertensive, and anti-inflammatory properties of citrus flavonoids. In animal models, supplementation of rodent diets with citrus flavonoids prevents hepatic steatosis, dyslipidemia, and insulin resistance primarily through inhibition of hepatic fatty acid synthesis and increased fatty acid oxidation. Citrus flavonoids blunt the inflammatory response in metabolically important tissues including liver, adipose, kidney, and the aorta. The mechanisms underlying flavonoid-induced metabolic regulation have not been completely established, although several potential targets have been identified. In mouse models, citrus flavonoids show marked suppression of atherogenesis through improved metabolic parameters as well as through direct impact on the vessel wall. Recent studies support a role for citrus flavonoids in the treatment of dyslipidemia, insulin resistance, hepatic steatosis, obesity, and atherosclerosis. Larger human studies examining dose, bioavailability, efficacy, and safety are required to promote the development of these promising therapeutic agents.

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Glucosyl Hesperidin Lowers Serum Triglyceride Level in Hypertriglyceridemic Subjects through the Improvement of Very Low-Density Lipoprotein Metabolic Abnormality
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Citrus Fruit Extracts Reduce Advanced Glycation End Products (AGEs)- and H2O2-Induced Oxidative Stress in Human Adipocytes
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Citrus flavonoid, naringenin, increases locomotor activity and reduces diacylglycerol accumulation in skeletal muscle of obese ovariectomized mice
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See all 228

Authors: Mulvihill, E. E., Burke, A. C., & Huff, M. W.
Affiliations: Western University (CA)
ORCID: Mulvihill, Erin E.
Huff, Murray W.
Venue: Annual Review of Nutrition
Publisher: Annual Reviews
Published: 2016-07-17
Volume: 36
Issue: 1
Pages: 275-299
ISSN: 0199-9885 (ISSN-L)
1545-4312
DOI: 10.1146/annurev-nutr-071715-050718
OpenAlex: W2211999579
Cited by: 228
References: 100
Citations by year: 2026: 20 · 2025: 15 · 2024: 24 · 2023: 19 · 2022: 26 · 2021: 31 · 2020: 38 · 2019: 25 · 2018: 17 · 2017: 9 · 2016: 4
FWCI: 1.78
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada (G-14-0006179)
Canadian Institutes of Health Research (T-7007)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Bioactive Compounds in Plants
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Keywords: citrus flavonoids, naringenin, hesperidin, nobiletin, tangeretin, lipoprotein metabolism, atherosclerosis, metabolic syndrome, dyslipidemia, insulin resistance, hepatic steatosis, hepatic fatty acid synthesis, fatty acid oxidation, anti-inflammatory activity, antihypertensive effect, cardiovascular disease prevention, obesity
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Hypolipidemic Agents, Antioxidants, Citrus, Diabetes Mellitus, Type 2, Flavonoids, Humans, Hyperlipidemias, Insulin Resistance, Lipoproteins, Risk Factors, Anti-Obesity Agents, Dietary Supplements, Overweight, Atherosclerosis, Non-alcoholic Fatty Liver Disease

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Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis

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