The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.
Breast Milk Oligosaccharides: Structure-Function Relationships in the Neonate
Open accessAbstract
In addition to providing complete postnatal nutrition, breast milk is a complex biofluid that delivers bioactive components for the growth and development of the intestinal and immune systems. Lactation is a unique opportunity to understand the role of diet in shaping the intestinal environment including the infant microbiome. Of considerable interest is the diversity and abundance of milk glycans that are energetically costly for the mammary gland to produce yet indigestible by infants. Milk glycans comprise free oligosaccharides, glycoproteins, glycopeptides, and glycolipids. Emerging technological advances are enabling more comprehensive, sensitive, and rapid analyses of these different classes of milk glycans. Understanding the impact of inter- and intraindividual glycan diversity on function is an important step toward interventions aimed at improving health and preventing disease. This review discusses the state of technology for glycan analysis and how specific structure-function knowledge is enhancing our understanding of early nutrition in the neonate.
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“This bacteria grows exceptionally well in the presence of complex milk oligosaccharides to the exclusion of other potentially harmful bacteria [27–29].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [29]
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Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
“To cite just a few examples, the following glycans were mostly unknown when the previous version of this review was being written: functional sialylation in the fly nervous system (181); O-fucose and O-glucose glycans on Notch (182–184), and O-fucose on thrombospondin repeats (185); mucin type O-glycosylation in proti…”
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“HMOs are structurally diverse and composed of several monosaccharides (glucose, galactose, N -acetylglucosamine, fucose, or sialic acid), and they mainly consist of a lactose core linked to units (n = 0 to 15) of lacto-N -biose (type I) or to N -acetyl- lactosamine (type II) (21).”
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Metadata
- Authors
- Smilowitz, J. T., Lebrilla, C. B., Mills, D. A., German, J. B., & Freeman, S. L.
- Affiliations
- Department of Food Science and Technology,
- Department of Chemistry, and
- University of California, Davis (US)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2014-07-17
- Volume
- 34
- Issue
- 1
- Pages
- 143-169
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- PMC
- PMC4348064
- OpenAlex
- W2157542971
- Cited by
- 410
- References
- 154
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 30 · 2023: 33 · 2022: 27 · 2021: 57 · 2020: 64 · 2019: 51 · 2018: 36 · 2017: 29 · 2016: 33 · 2015: 15 · 2014: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Bill and Melinda Gates Foundation
- California Dairy Research Foundation
- National Institutes of Health
- University of California, Davis
- National Center for Complementary and Integrative Health (R01AT007079, R21AT006180)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065122, R01HD061923, R01HD059127)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- human milk oligosaccharides, structure-function relationship, neonatal nutrition, infant microbiome, intestinal development, immune system development, glycoproteins, glycopeptides, glycolipids, lactation
- MeSH terms
- Bifidobacterium, Breast Feeding, Carbohydrate Sequence, Child Development, Female, Glycolipids, Glycopeptides, Glycoproteins, Humans, Immunity, Innate, Infant, Newborn, Intestinal Mucosa, Lactation, Male, Milk Proteins, Milk, Human, Models, Biological, Oligosaccharides
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