The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
MicroRNAs in Cancer
Open accessAbstract
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration. Thus, miRNAs have been implicated in the regulation of virtually all signaling circuits within a cell, and their dysregulation has been shown to play an essential role in the development and progression of cancer. Here, after a brief description of miRNA genomics, biogenesis, and function, we discuss the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies.
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Most mammalian mRNAs are conserved targets of microRNAs
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Self-citationIdentification of Novel Genes Coding for Small Expressed RNAs
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Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
Treiber, T., Treiber, N., & Meister, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0059-1 · Cited by 1,252
Metastatic Stem Cells: Sources, Niches, and Vital Pathways
Oskarsson, T., Batlle, E., & Massagué, J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.02.002 · Cited by 708
MicroRNA and cancer – A brief overview
Acunzo, M., Romano, G., Wernicke, D., & Croce, C. M. (2015) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.09.013 · Cited by 630
Self-citationmirDIP 4.1—integrative database of human microRNA target predictions
Tokar, T., Pastrello, C., Rossos, A. E. M., Abovsky, M., Hauschild, A.-C., Tsay, M., Lu, R., & Jurisica, I. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1144 · Cited by 572
Metadata
- Authors
- Di Leva, G., Garofalo, M., & Croce, C. M.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2014-01-24
- Volume
- 9
- Issue
- 1
- Pages
- 287-314
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2109227959
- Cited by
- 1,672
- References
- 50
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Di Leva, G., Garofalo, M., & Croce, C. M. (2014). MicroRNAs in Cancer. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathol-012513-104715
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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