The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Disorders of Vascular Permeability
Open accessAbstract
The endothelial barrier maintains vascular and tissue homeostasis and modulates many physiological processes, such as angiogenesis. Vascular barrier integrity can be disrupted by a variety of soluble permeability factors, and changes in barrier function can exacerbate tissue damage during disease progression. Understanding endothelial barrier function is critical for vascular homeostasis. Many of the signaling pathways promoting vascular permeability can also be triggered during disease, resulting in prolonged or uncontrolled vascular leak. It is believed that recovery of the normal vasculature requires diminishing this hyperpermeable state. Although the molecular mechanisms governing vascular leak have been studied over the last few decades, recent advances have identified new therapeutic targets that have begun to show preclinical and clinical promise. These approaches have been successfully applied to an increasing number of disease conditions. New perspectives regarding how vascular leak impacts the progression of various diseases are highlighted in this review.
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Cited by
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies
Claesson-Welsh, L., Dejana, E., & McDonald, D. M. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.11.006 · Cited by 631
Sun, H.-J., Wu, Z.-Y., Nie, X.-W., & Bian, J.-S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01568 · Cited by 554
Contribution of Angiogenesis to Inflammation and Cancer
Aguilar-Cazares, D., Chavez-Dominguez, R., Carlos-Reyes, A., Lopez-Camarillo, C., Hernadez de la Cruz, O. N., & Lopez-Gonzalez, J. S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01399 · Cited by 317
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation
Wettschureck, N., Strilic, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 286
Das, D., Shruthi, N. R., Banerjee, A., Jothimani, G., Duttaroy, A. K., & Pathak, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1221438 · Cited by 90
“These molecules play a crucial role in enhancing the processes of endothelial cell proliferation, migration, and permeability (84).”
Background
Metadata
- Authors
- Park-Windhol, C., & D'Amore, P. A.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2016-05-23
- Volume
- 11
- Issue
- 1
- Pages
- 251-281
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2275176035
- Cited by
- 190
- References
- 10
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Park-Windhol, C., & D'Amore, P. A. (2016). Disorders of Vascular Permeability. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathol-012615-044506
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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