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Cited by 384Spine and Intervertebral Disc PathologyCervical and Thoracic MyelopathyOsteoarthritis Treatment and Mechanisms

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

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Feng, Chencheng, Yang, Minghui, Lan, Minghong, Liu, Chang, Zhang, Yang, Huang, Bo, Liu, Huan, Zhou, Yue·2017·Oxidative Medicine and Cellular Longevity
DOI 10.1155/2017/5601593PMC PMC5368368
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Abstract

Excessive reactive oxygen species (ROS) generation in degenerative intervertebral disc (IVD) indicates the contribution of oxidative stress to IVD degeneration (IDD), giving a novel insight into the pathogenesis of IDD. ROS are crucial intermediators in the signaling network of disc cells. They regulate the matrix metabolism, proinflammatory phenotype, apoptosis, autophagy, and senescence of disc cells. Oxidative stress not only reinforces matrix degradation and inflammation, but also promotes the decrease in the number of viable and functional cells in the microenvironment of IVDs. Moreover, ROS modify matrix proteins in IVDs to cause oxidative damage of disc extracellular matrix, impairing the mechanical function of IVDs. Consequently, the progression of IDD is accelerated. Therefore, a therapeutic strategy targeting oxidative stress would provide a novel perspective for IDD treatment. Various antioxidants have been proposed as effective drugs for IDD treatment. Antioxidant supplementation suppresses ROS production in disc cells to promote the matrix synthesis of disc cells and to prevent disc cells from death and senescence in vitro. However, there is not enough in vivo evidence to support the efficiency of antioxidant supplementation to retard the process of IDD. Further investigations based on in vivo and clinical studies will be required to develop effective antioxidative therapies for IDD.

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Cited by

Sorted by citations

Authors
Feng, C., Yang, M., Lan, M., Liu, C., Zhang, Y., Huang, B., Liu, H., & Zhou, Y.
Affiliations
Army Medical University (CN)
Corresponding author
  • Liu, Huan
  • Zhou, Yue
ORCID
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2017-01
Volume
2017
Issue
1
Pages
5601593-5601593
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
DOI
10.1155/2017/5601593
PMC
PMC5368368
OpenAlex
W2603552684
Cited by
384
References
6
Citations by year
2026: 34 · 2025: 44 · 2024: 48 · 2023: 60 · 2022: 77 · 2021: 51 · 2020: 27 · 2019: 25 · 2018: 15 · 2017: 3
FWCI
3.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81572186, 81271982, 81472076, 81401801)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spine and Intervertebral Disc Pathology
  • Health Sciences › Medicine › Surgery › Cervical and Thoracic Myelopathy
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords
intervertebral disc degeneration, reactive oxygen species, oxidative stress, matrix degradation, inflammation, apoptosis, autophagy, cellular senescence, antioxidant supplementation
MeSH terms
Homeostasis, Humans, Intervertebral Disc, Oxidation-Reduction, Reactive Oxygen Species, Intervertebral Disc Degeneration, Cellular Microenvironment

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