The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Tight Junction Pore and Leak Pathways: A Dynamic Duo
Open accessAbstract
Tissue barriers that restrict passage of liquids, ions, and larger solutes are essential for the development of multicellular organisms. In simple organisms this allows distinct cell types to interface with the external environment. In more complex species, the diversity of cell types capable of forming barriers increases dramatically. Although the plasma membranes of these barrier-forming cells prevent flux of most hydrophilic solutes, the paracellular, or shunt, pathway between cells must also be sealed. This function is accomplished in vertebrates by the zonula occludens, or tight junction. The tight junction barrier is not absolute but is selectively permeable and is able to discriminate between solutes on the basis of size and charge. Many tight junction components have been identified over the past 20 years, and recent progress has provided new insights into the proteins and interactions that regulate structure and function. This review presents these data in a historical context and proposes an integrated model in which dynamic regulation of tight junction protein interactions determines barrier function.
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Cites
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Cited by
The intestinal epithelial barrier: a therapeutic target?
Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288
Self-citationIntestinal barrier function in health and gastrointestinal disease
Camilleri, M., Madsen, K., Spiller, R., Van Meerveld, B. G., & Verne, G. N. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01921.x · Cited by 908
Renal Control of Calcium, Phosphate, and Magnesium Homeostasis
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The blood-brain barrier: an engineering perspective
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Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival
Kuo, W., Odenwald, M. A., Turner, J. R., & Zuo, L. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14798 · Cited by 616
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Metadata
- Authors
- Shen, L., Weber, C. R., Raleigh, D. R., Yu, D., & Turner, J. R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2011-03-17
- Volume
- 73
- Issue
- 1
- Pages
- 283-309
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2161762907
- Cited by
- 872
- References
- 142
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- green
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