Cited by 1,258ATP Synthase and ATPases ResearchCellular transport and secretionIon Transport and Channel Regulation

The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.

Lysosomal Acidification Mechanisms

Mindell, Joseph A.·2012·Annual Review of Physiology

DOI 10.1146/annurev-physiol-012110-142317

Open this paper in CoChat — free account

Abstract

Lysosomes, the terminal organelles on the endocytic pathway, digest macromolecules and make their components available to the cell as nutrients. Hydrolytic enzymes specific to a wide range of targets reside within the lysosome; these enzymes are activated by the highly acidic pH (between 4.5 and 5.0) in the organelles' interior. Lysosomes generate and maintain their pH gradients by using the activity of a proton-pumping V-type ATPase, which uses metabolic energy in the form of ATP to pump protons into the lysosome lumen. Because this activity separates electric charge and generates a transmembrane voltage, another ion must move to dissipate this voltage for net pumping to occur. This so-called counterion may be either a cation (moving out of the lysosome) or an anion (moving into the lysosome). Recent data support the involvement of ClC-7, a Cl(-)/H(+) antiporter, in this process, although many open questions remain as to this transporter's involvement. Although functional results also point to a cation transporter, its molecular identity remains uncertain. Both the V-ATPase and the counterion transporter are likely to be important players in the mechanisms determining the steady-state pH of the lysosome interior. Exciting new results suggest that lysosomal pH may be dynamically regulated in some cell types.

Integrity signals

Registry

Crossref · 10.1146/annurev-physiol-012110-142317

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Forgac, M. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2272 · Cited by 1,626
AN INTRODUCTION TO TRP CHANNELS
Ramsey, I. S., Delling, M., & Clapham, D. E. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100431 · Cited by 1,596
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,490
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T., & MacKinnon, R. (2002) · Nature · doi:10.1038/415287a · Cited by 1,446
Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
Satyanarayana, A., & Kaldis, P. (2009) · Oncogene · doi:10.1038/onc.2009.170 · Cited by 800
NAADP mobilizes calcium from acidic organelles through two-pore channels
Calcraft, P. J., Ruas, M., Pan, Z., Cheng, X., Arredouani, A., Hao, X., Tang, J., Rietdorf, K., Teboul, L., Chuang, K.-T., et al. (2009) · Nature · doi:10.1038/nature08030 · Cited by 760
Gating the Selectivity Filter in ClC Chloride Channels
Dutzler, R., Campbell, E. B., & MacKinnon, R. (2003) · Science · doi:10.1126/science.1082708 · Cited by 727
The ABC protein turned chloride channel whose failure causes cystic fibrosis
Gadsby, D. C., Vergani, P., & Csanády, L. (2006) · Nature · doi:10.1038/nature04712 · Cited by 726
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness
Karet, F. E., Finberg, K. E., Nelson, R. D., Nayır, A., Mocan, H. N., Sanjad, S. A., Rodríguez‐Soriano, J., Santos, F., Cremers, C. W. R. J., Pietro, A. D., et al. (1999) · Nature Genetics · doi:10.1038/5022 · Cited by 687

Show all 93 references

Sorted by citations

Items 201–300 of 1,000

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
Zhou, M., Ottenberg, G. K., Sferrazza, G. F., Hubbs, C., Fallahi, M., Rumbaugh, G., Brantley, A. F., & Lasmézas, C. I. (2015) · Brain · doi:10.1093/brain/awv002 · Cited by 77
pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells
Chen, X., Jaiswal, A., Costliow, Z. A., Herbst, P., Creasey, E. A., Oshiro-Rapley, N., Daly, M. J., Carey, K. L., Graham, D. B., & Xavier, R. J. (2022) · Nature Immunology · doi:10.1038/s41590-022-01231-0 · Cited by 79
Evaluation of Boron Nitride Nanotubes and Hexagonal Boron Nitrides As Nanocarriers for Cancer Drugs
Emanet, M., Şen, Ö., & Çulha, M. (2017) · Nanomedicine · doi:10.2217/nnm-2016-0322 · Cited by 77
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses
Li, P., Hu, M., Wang, C., Feng, X., Zhao, Z., Yang, Y., Sahoo, N., Gu, M., Yang, Y., Xiao, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016539117 · Cited by 76
Intracellular transport of nanocarriers across the intestinal epithelium
Fan, W., Xia, D., Zhu, Q., Hu, L., & Gan, Y. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.04.007 · Cited by 77
Multifunctional hybrid nanoparticles as magnetic delivery systems for siRNA targeting the HER2 gene in breast cancer cells
Cristofolini, T., Dalmina, M., Sierra, J. A., Silva, A. H., Pasa, A. A., Pittella, F., & Creczynski‐Pasa, T. B. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110555 · Cited by 76
Block Copolymer Capsules with Structure‐Dependent Release Behavior
Xu, J., Li, J., Yang, Y., Wang, K., Xu, N., Li, J., Liang, R., Shen, L., Xie, X., Tao, J., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201607982 · Cited by 75
Quantitative Evaluation of Surface-Enhanced Raman Scattering Nanoparticles for Intracellular pH Sensing at a Single Particle Level
Zhang, Z., Bando, K., Mochizuki, K., Taguchi, A., Fujita, K., & Kawata, S. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03276 · Cited by 74
Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c
Ansari, M. Y., Ball, H. C., Wase, S., Novak, K. A., & Haqqi, T. M. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2020.08.014 · Cited by 74
Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance
Leray, X., Hilton, J. K., Nwangwu, K., Becerril, A. J., Mikušević, V., Fitzgerald, G. A., Amin, A., Weston, M. R., & Mindell, J. A. (2022) · eLife · doi:10.7554/elife.74136 · Cited by 77
Self-citation
The role of lysosome in cell death regulation
Yu, F., Chen, Z., Wang, B., Zhao, J., Hou, Y., Ma, S., & Liu, X. (2015) · Tumor Biology · doi:10.1007/s13277-015-4516-6 · Cited by 70
Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells
Zielke, S., Meyer, N. E., Mari, M. C., Abou‐El‐Ardat, K., Reggiori, F., van Wijk, S. J. L., Kögel, D., & Fulda, S. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1003-1 · Cited by 72
Sublethal Levels of Antibiotics Promote Bacterial Persistence in Epithelial Cells
Liu, X., Liu, F., Ding, S., Shen, J., & Zhu, K. (2020) · Advanced Science · doi:10.1002/advs.201900840 · Cited by 72
Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
Osei‐Owusu, J., Yang, J., Leung, K., Ruan, Z., Lü, W., Krishnan, Y., & Qiu, Z. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108683 · Cited by 71
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice
Monsorno, K., Ginggen, K., Ivanov, A., Buckinx, A., Lalive, A. L., Tchenio, A., Benson, S., Vendrell, M., D’Alessandro, A., Beule, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41502-4 · Cited by 72
Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins
Blau, R., Epshtein, Y., Pisarevsky, E., Tiram, G., Dangoor, S. I., Yeini, E., Krivitsky, A., Eldar‐Boock, A., Ben‐Shushan, D., Gibori, H., et al. (2018) · Theranostics · doi:10.7150/thno.23853 · Cited by 71
CeO 2 NPs, toxic or protective to phytoplankton? Charge of nanoparticles and cell wall as factors which cause changes in cell complexity
Sendra, M., Yeste, M. P., Moreno‐Garrido, I., Gatica, J. M., & Blasco, J. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.03.007 · Cited by 70
Proton gradients and pH oscillations emerge from heat flow at the microscale
Keil, L. M. R., Möller, F. M., Kieß, M., Kudella, P. W., & Mast, C. B. (2017) · Nature Communications · doi:10.1038/s41467-017-02065-3 · Cited by 68
Melatonin alleviates lead-induced fatty liver in the common carps (Cyprinus carpio) via gut-liver axis
Miao, Z., Miao, Z., Teng, X., & Xu, S. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120730 · Cited by 69
Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers
Erbaş-Çakmak, S., Cakmak, F. P., Topel, S. D., Uyar, T. B., & Akkaya, E. U. (2015) · Chemical Communications · doi:10.1039/c5cc01261a · Cited by 69
The role of HBV-induced autophagy in HBV replication and HBV related-HCC
Xie, M., Yang, Z., Liu, Y., & Zheng, M. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.04.051 · Cited by 69
Integrating Fluorinated Polymer and Manganese‐Layered Double Hydroxide Nanoparticles as pH‐activated 19F MRI Agents for Specific and Sensitive Detection of Breast Cancer
Zhang, C., Li, L., Han, F. Y., Yu, X., Tan, X., Fu, C., Xu, Z. P., & Whittaker, A. K. (2019) · Small · doi:10.1002/smll.201902309 · Cited by 68
Mechanisms of alkaliptosis
Chen, F., Kang, R., Liu, J., & Tang, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1213995 · Cited by 70
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions
Yoon, M. C., Solania, A., Jiang, Z., Christy, M. P., Podvin, S., Mosier, C., Lietz, C. B., Ito, G., Gerwick, W. H., Wolan, D. W., et al. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00138 · Cited by 67
ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis
Chen, F., Zhu, S., Kang, R., Tang, D., & Liu, J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111911 · Cited by 68
Manipulating Autophagic Processes in Autoimmune Diseases: A Special Focus on Modulating Chaperone-Mediated Autophagy, an Emerging Therapeutic Target
Wang, F., & Muller, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00252 · Cited by 70
Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes
Li, X., Garrity, A. G., & Xu, H. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.258301 · Cited by 71
Effect of erythromycin and modulating effect of CeO2 NPs on the toxicity exerted by the antibiotic on the microalgae Chlamydomonas reinhardtii and Phaeodactylum tricornutum
Sendra, M., Moreno‐Garrido, I., Blasco, J., & Araújo, C. V. M. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.07.009 · Cited by 66
The expanding organelle lipidomes: current knowledge and challenges
Sarmento, M. J., Llorente, A., Petan, T., Khnykin, D., Popa, I., Perković, M. N., Konjevod, M., & Jaganjac, M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04889-3 · Cited by 74
Protein aggregates and proteostasis in aging: Amylin and β-cell function
Press, M., Jung, T., König, J., Grune, T., & Höhn, A. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.010 · Cited by 66
Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction
Wang, J., Rousseau, J., Kim, E., Ehresmann, S., Cheng, Y.-T., Duraine, L., Zuo, Z., Park, Y.-J., Li‐Kroeger, D., Bi, W., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.11.002 · Cited by 63
Wahrnehmung der chemischen Prozesse in einzelnen Organellen mit niedermolekularen Fluoreszenzsonden
Xu, W., Zeng, Z., Jiang, J., Chang, Y., & Yuan, L. (2016) · Angewandte Chemie · doi:10.1002/ange.201510721 · Cited by 64
A fluorescent probe for bisulfite ions: its application to two-photon tissue imaging
Agarwalla, H., Pal, S., Paul, A., Jun, Y. W., Bae, J., Ahn, K. H., Srivastava, D. N., & Das, A. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb02637k · Cited by 64
Recent Insights Into the Pathogenic Mechanism of Pancreatitis
Gukovskaya, A. S., Gorelick, F. S., Groblewski, G. E., Mareninova, O. A., Lugea, A., Antonucci, L., Waldron, R. T., Habtezion, A., Karin, M., Pandol, S. J., et al. (2019) · Pancreas · doi:10.1097/mpa.0000000000001298 · Cited by 64
Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 2. Specifying probe, protocol and cell factors; selecting QSAR models; predicting entry and localization
Horobin, R. W., & Rashid‐Doubell, F. (2013) · Biotechnic & Histochemistry · doi:10.3109/10520295.2013.780635 · Cited by 63
Lysosomal solute and water transport
Hu, M., Zhou, N., Cai, W., & Xu, H. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202109133 · Cited by 62
Annexins as Overlooked Regulators of Membrane Trafficking in Plant Cells
Konopka‐Postupolska, D., & Clark, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040863 · Cited by 66
Recent advances in the development of polyethylenimine-based gene vectors for safe and efficient gene delivery
Jiang, C., Chen, J., Li, Z., Wang, Z., Zhang, W., & Liu, J. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1604681 · Cited by 67
Dual targeting smart drug delivery system for multimodal synergistic combination cancer therapy with reduced cardiotoxicity
Shubhra, Q. T. H., Guo, K., Liu, Y., Razzak, M., Manir, M. S., & Alam, A. K. M. M. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.016 · Cited by 61
Tumor Intracellular‐Environment Responsive Materials Shielded Nano‐Complexes for Highly Efficient Light‐Triggered Gene Delivery without Cargo Gene Damage
Park, S., Park, W., & Na, K. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500737 · Cited by 61
Triblock Copolymer Nanovesicles for pH-Responsive Targeted Delivery and Controlled Release of siRNA to Cancer Cells
Gallon, E., Matini, T., Sasso, L., Mantovani, G., Armiñán, A., Sanchis, J., Caliceti, P., Alexander, C., Vicent, M. J., & Salmaso, S. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00286 · Cited by 64
VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway
Mao, D., Lin, G., Tepe, B., Zuo, Z., Tan, K. L., Şentürk, M., Zhang, S., Arenkiel, B. R., Sardiello, M., & Bellen, H. J. (2019) · Autophagy · doi:10.1080/15548627.2019.1580103 · Cited by 59
Misfolded amyloid-β-42 impairs the endosomal–lysosomal pathway
Marshall, K. E., Vadukul, D. M., Staras, K., & Serpell, L. C. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03464-4 · Cited by 61
Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase
Sasaki, T., Lian, S., Khan, A., Llop, J. R., Samuelson, A. V., Chen, W., Klionsky, D. J., & Kishi, S. (2017) · Autophagy · doi:10.1080/15548627.2016.1256934 · Cited by 60
Modulating lysosomal pH: a molecular and nanoscale materials design perspective
Zeng, J., Shirihai, O. S., & Grinstaff, M. W. (2020) · JoLS Journal of Life Sciences · doi:10.36069/jols/20201204 · Cited by 65
Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use
Aquib, M., Farooq, M. A., Banerjee, P., Akhtar, F., Filli, M. S., Boakye‐Yiadom, K. O., Kesse, S., Raza, F., Maviah, M. B. J., Mavlyanova, R., et al. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36770 · Cited by 59
Structure-function relationships of nonviral gene vectors: Lessons from antimicrobial polymers
Xing, H., Lu, M., Yang, T., Liu, H., Sun, Y., Zhao, X., Xu, H., Yang, L., & Ding, P. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.041 · Cited by 59
Doxorubicin–Gelatin/Fe3O4–Alginate Dual-Layer Magnetic Nanoparticles as Targeted Anticancer Drug Delivery Vehicles
Huang, C.-H., Chuang, T.-J., Ke, C., & Yao, C. (2020) · Polymers · doi:10.3390/polym12081747 · Cited by 60
Real-Time and High-Fidelity Tracking of Lysosomal Dynamics with a Dicyanoisophorone-Based Fluorescent Probe
Hong, J., Li, Q., Xia, Q., & Feng, G. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04341 · Cited by 59
Vacuolar H+-ATPase: An Essential Multitasking Enzyme in Physiology and Pathophysiology
Holliday, L. S. (2014) · New Journal of Science · doi:10.1155/2014/675430 · Cited by 60
Facile Preparation of Doxorubicin-Loaded and Folic Acid-Conjugated Carbon Nanotubes@Poly(N-vinyl pyrrole) for Targeted Synergistic Chemo–Photothermal Cancer Treatment
Wang, D., Ren, Y., Shao, Y., Yu, D., & Meng, L. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00515 · Cited by 59
Therapeutic Strategies to Target Calcium Dysregulation in Alzheimer’s Disease
Calvo-Rodríguez, M., Kharitonova, E. K., & Bacskai, B. J. (2020) · Cells · doi:10.3390/cells9112513 · Cited by 60
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases
Ikeda, S., Nah, J., Shirakabe, A., Zhai, P., Oka, S., Sciarretta, S., Guan, K., Shimokawa, H., & Sadoshima, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci143173 · Cited by 57
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells
Xiaoli, F., Zhang, Y., Luo, R., Xuan, L., Chen, A., Yanli, Z., Hu, C., Chen, L., & Longquan, S. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126158 · Cited by 59
Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY
Zhu, M., Xing, P., Zhou, Y., Gong, L., Zhang, J., Qi, D., Bian, Y., Du, H., & Jiang, J. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00883c · Cited by 58
Efficient uptake and retention of iron oxide-based nanoparticles in HeLa cells leads to an effective intracellular delivery of doxorubicin
Popescu, R. C., Savu, D., Dorobantu, I. A., Vasile, B. Ş., Hosser, H., Boldeiu, A., Temelie, M., Straticiuc, M., Iancu, D., Andronescu, E., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67207-y · Cited by 59
The role of endolysosomal trafficking in anticancer drug resistance
Hussein, N. A., Malla, S., Pasternak, M. A., Terrero, D., Brown, N. G., Ashby, C. R., Assaraf, Y. G., Chen, Z., & Tiwari, A. K. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100769 · Cited by 58
Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function
Uzhytchak, M., Smolková, B., Lunová, M., Frtús, A., Jirsa, M., Dejneka, A., & Lunov, O. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114828 · Cited by 61
A lysosomal chloride ion-selective fluorescent probe for biological applications
Park, S.-H., Hyun, J. Y., & Shin, I. (2018) · Chemical Science · doi:10.1039/c8sc04084b · Cited by 57
Upconversion nanoparticle-mOrange protein FRET nanoprobes for self-ratiometric/ratiometric determination of intracellular pH, and single cell pH imaging
Ghosh, S., Chang, Y.-F., Yang, D., & Chattopadhyay, S. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112115 · Cited by 56
Imaging the electrical activity of organelles in living cells
Matamala, E., Castillo, C., Vivar, J. P., Rojas, P. A., & Brauchi, S. E. (2021) · Communications Biology · doi:10.1038/s42003-021-01916-6 · Cited by 56
Extralysosomal cathepsin B in central nervous system: Mechanisms and therapeutic implications
Ni, J., Lan, F., Xu, Y. C., Nakanishi, H., & Li, X. (2022) · Brain Pathology · doi:10.1111/bpa.13071 · Cited by 56
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?
Riederer, E. A., Cang, C., & Ren, D. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051921-013755 · Cited by 58
The role of a Schiff base scaffold, N-(2-hydroxy acetophenone) glycinate-in overcoming multidrug resistance in cancer
Ganguly, A., Chakraborty, P., Banerjee, K., & Choudhuri, S. K. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.09.003 · Cited by 57
Impact of cellular health conditions on the protein folding state in mammalian cells
Inomata, K., Kamoshida, H., Ikari, M., Ito, Y., & Kigawa, T. (2017) · Chemical Communications · doi:10.1039/c7cc06004a · Cited by 56
Redox-Linked Coordination Chemistry Directs Vitamin B 12 Trafficking
Banerjee, R. V., Gouda, H., & Pillay, S. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00083 · Cited by 56
Conduits of Life’s Spark: A Perspective on Ion Channel Research since the Birth of Neuron
Isacoff, E. Y., Jan, L. Y., & Minor, D. L. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.040 · Cited by 57
Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems
Lu, M., Xing, H., Xun, Z., Yang, T., Zhao, X., Cai, C., Wang, D., & Ding, P. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.05.001 · Cited by 56
The N-terminal 14-mer model peptide of human Ctr1 can collect Cu( ii ) from albumin. Implications for copper uptake by Ctr1
Stefaniak, E., Płonka, D., Drew, S. C., Bossak‐Ahmad, K., Haas, K. L., Pushie, M. J., Faller, P., Wezynfeld, N. E., & Bal, W. (2018) · Metallomics · doi:10.1039/c8mt00274f · Cited by 55
Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3ʹ UTR-Directed Regulation and Nonsense-Mediated Decay
Zhu, X., Zhang, H., & Mendell, J. T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107895 · Cited by 55
Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle
Marques, A. R. A., Ramos, C., Machado-Oliveira, G., & Vieira, O. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.658995 · Cited by 53
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress
Yan, J., Zhang, W., Yan, L., Jiao, Y., Zhou, C., & Yu, X. (2021) · Autophagy · doi:10.1080/15548627.2021.1994296 · Cited by 53
Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency
Sasaki, T., Lian, S., Qi, J., Bayliss, P. E., Carr, C. E., Johnson, J. L., Guha, S., Kobler, P., Catz, S. D., Gill, M. S., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004409 · Cited by 57
Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes
Valapala, M., Hose, S., Gongora, C., Dong, L., Wawrousek, E. F., Zigler, J. S., & Sinha, D. (2013) · Nature Communications · doi:10.1038/ncomms2624 · Cited by 55
FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans
Dhondt, I., Petyuk, V., Cai, H., Vandemeulebroucke, L., Vierstraete, A. R., Smith, R. D., Depuydt, G., & Braeckman, B. P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.088 · Cited by 55
Molecular insights into the human CLC-7/Ostm1 transporter
Zhang, S., Liu, Y., Zhang, B., Zhou, J., Li, T., Liu, Z., Li, Y., & Yang, M. (2020) · Science Advances · doi:10.1126/sciadv.abb4747 · Cited by 54
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus
Lee, C. H., Song, D. K., Park, C. B., Choi, J., Kang, G. M., Shin, S. H., Kwon, I., Park, S., Kim, S., Kim, J. Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19638-4 · Cited by 54
A Fluorescent Indicator for Imaging Lysosomal Zinc(II) with Förster Resonance Energy Transfer (FRET)‐Enhanced Photostability and a Narrow Band of Emission
Sreenath, K., Yuan, Z., Allen, J. R., Davidson, M. W., & Zhu, L. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201403479 · Cited by 52
Phagocyte Escape of Leptospira: The Role of TLRs and NLRs
Santecchia, I., Ferrer, M. F., Vieira, M. L., Gomez, R. M., & Werts, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571816 · Cited by 51
Role of Endolysosomes in Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Coronavirus Disease 2019 Pathogenesis: Implications for Potential Treatments
Khan, N., Chen, X., & Geiger, J. D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.595888 · Cited by 51
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics
Allemailem, K. S., Almatroudi, A., Alrumaihi, F., Almatroodi, S. A., Alkurbi, M. O., Basfar, G. T., Rahmani, A. H., & Khan, A. A. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s321343 · Cited by 53
CLN7 is an organellar chloride channel regulating lysosomal function
Wang, Y., Zeng, W., Lin, B., Yao, Y., Li, C., Hu, W., Wu, H., Huang, J., Zhang, M., Xue, T., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj9608 · Cited by 52
Blockage of Autophagy for Cancer Therapy: A Comprehensive Review
Hassan, A., Zhao, Y., Chen, X., & He, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137459 · Cited by 55
Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease
Kiraly, S., Stanley, J., & Eden, E. R. (2025) · Antioxidants · doi:10.3390/antiox14020125 · Cited by 58
Zeolitic imidazolate metal organic framework-8 as an efficient pH-controlled delivery vehicle for zinc phthalocyanine in photodynamic therapy
Song, M., Li, D.-Y., Nian, F.-Y., Xue, J., & Chen, J. (2017) · Journal of Materials Science · doi:10.1007/s10853-017-1716-z · Cited by 52
Phasor–Fluorescence Lifetime Imaging Microscopy Analysis to Monitor Intercellular Drug Release from a pH-Sensitive Polymeric Nanocarrier
Zhou, T., Luo, T., Song, J., & Qu, J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04511 · Cited by 52
The hidden potential of lysosomal ion channels: A new era of oncogenes
Sterea, A. M., Almasi, S., & Hiani, Y. E. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.02.006 · Cited by 52
Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging
Teeman, E., Shasha, C., Evans, J. E., & Krishnan, K. M. (2019) · Nanoscale · doi:10.1039/c9nr01395d · Cited by 56
Vesicular Transport Machinery in Brain Endothelial Cells: What We Know and What We Do not
Tóth, A. E., Holst, M. R., & Nielsen, M. S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200212113421 · Cited by 56
A Compendium of Information on the Lysosome
Bouhamdani, N., Comeau, D., & Turcotte, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.798262 · Cited by 55
IL-12 and IL-27 regulate the phagolysosomal pathway in mycobacteria-infected human macrophages
Jung, J., & Robinson, C. M. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-16 · Cited by 51
Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection
Sanman, L. E., van der Linden, W. A., Verdoes, M., & Bogyo, M. S. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.05.019 · Cited by 51
Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations
Yamamoto, Y., Danhof, M., & de Lange, E. C. M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0050-3 · Cited by 53
Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond
Webber, E. K., Fivaz, M., Stutzmann, G. E., & Griffioen, G. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13065 · Cited by 50
A Nanomedicine Structure–Activity Framework for Research, Development, and Regulation of Future Cancer Therapies
Youden, B., Jiang, R., Carrier, A. J., Servos, M. R., & Zhang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c06337 · Cited by 53
Surface‐Functionalizable Plant‐Derived Extracellular Vesicles for Targeted Drug Delivery Carrier Using Grapefruit
Moon, K., Hur, J., Kim, K. P., Lee, K., & Kang, J. Y. (2023) · Advanced Materials Interfaces · doi:10.1002/admi.202300220 · Cited by 56
Porous Molybdenum Nitride Nanosphere as Carrier-Free and Efficient Nitric Oxide Donor for Synergistic Nitric Oxide and Chemo/Sonodynamic Therapy
Bai, Q., Wang, M., Liu, J., Sun, X., Yang, P., Qu, F., & Lin, H. (2023) · ACS Nano · doi:10.1021/acsnano.3c05790 · Cited by 50
The Outcome of the Cryptococcus neoformans–Macrophage Interaction Depends on Phagolysosomal Membrane Integrity
Leon-Rodriguez, C. M. D., Rossi, D. C. P., Fu, M. S., Dragotakes, Q., Coelho, C., Guerrero‐Ros, I., Caballero, B., Nolan, S. J., & Casadevall, A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700958 · Cited by 49
Hijacking Endocytosis and Autophagy in Extracellular Vesicle Communication: Where the Inside Meets the Outside
Pedrioli, G., & Paganetti, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.595515 · Cited by 50
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B
Yoon, M. C., Christy, M. P., Phan, V. V., Gerwick, W. H., Hook, G., O’Donoghue, A. J., & HOOK, V. Y. H. (2022) · Biochemistry · doi:10.1021/acs.biochem.1c00684 · Cited by 49

Authors: Mindell, J. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Mindell, Joseph A.
ORCID: Mindell, Joseph A.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2012-03-17
Volume: 74
Issue: 1
Pages: 69-86
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev-physiol-012110-142317
OpenAlex: W2000678720
Cited by: 1,258
References: 93
Citations by year: 2026: 99 · 2025: 123 · 2024: 133 · 2023: 106 · 2022: 109 · 2021: 113 · 2020: 106 · 2019: 112 · 2018: 83 · 2017: 76 · 2016: 69 · 2015: 51 · 2014: 40 · 2013: 31 · 2012: 5
FWCI: 2.21
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: lysosomal acidification, lysosomal pH, V-type ATPase, proton translocation, counterion transport, ClC-7, cation transport, endocytic pathway, pH control
MeSH terms: Animals, Biotransformation, Cations, Humans, Hydrogen-Ion Concentration, Ions, Lysosomes, Chloride Channels, Cystic Fibrosis Transmembrane Conductance Regulator, Vacuolar Proton-Translocating ATPases, Electrophysiological Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lysosomal Acidification Mechanisms

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks