Cited by 1,258ATP Synthase and ATPases ResearchCellular transport and secretionIon Transport and Channel Regulation

The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.

Lysosomal Acidification Mechanisms

Mindell, Joseph A.·2012·Annual Review of Physiology

DOI 10.1146/annurev-physiol-012110-142317

Open this paper in CoChat — free account

Abstract

Lysosomes, the terminal organelles on the endocytic pathway, digest macromolecules and make their components available to the cell as nutrients. Hydrolytic enzymes specific to a wide range of targets reside within the lysosome; these enzymes are activated by the highly acidic pH (between 4.5 and 5.0) in the organelles' interior. Lysosomes generate and maintain their pH gradients by using the activity of a proton-pumping V-type ATPase, which uses metabolic energy in the form of ATP to pump protons into the lysosome lumen. Because this activity separates electric charge and generates a transmembrane voltage, another ion must move to dissipate this voltage for net pumping to occur. This so-called counterion may be either a cation (moving out of the lysosome) or an anion (moving into the lysosome). Recent data support the involvement of ClC-7, a Cl(-)/H(+) antiporter, in this process, although many open questions remain as to this transporter's involvement. Although functional results also point to a cation transporter, its molecular identity remains uncertain. Both the V-ATPase and the counterion transporter are likely to be important players in the mechanisms determining the steady-state pH of the lysosome interior. Exciting new results suggest that lysosomal pH may be dynamically regulated in some cell types.

Integrity signals

Registry

Crossref · 10.1146/annurev-physiol-012110-142317

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Forgac, M. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2272 · Cited by 1,626
AN INTRODUCTION TO TRP CHANNELS
Ramsey, I. S., Delling, M., & Clapham, D. E. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100431 · Cited by 1,596
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,490
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T., & MacKinnon, R. (2002) · Nature · doi:10.1038/415287a · Cited by 1,446
Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
Satyanarayana, A., & Kaldis, P. (2009) · Oncogene · doi:10.1038/onc.2009.170 · Cited by 800
NAADP mobilizes calcium from acidic organelles through two-pore channels
Calcraft, P. J., Ruas, M., Pan, Z., Cheng, X., Arredouani, A., Hao, X., Tang, J., Rietdorf, K., Teboul, L., Chuang, K.-T., et al. (2009) · Nature · doi:10.1038/nature08030 · Cited by 760
Gating the Selectivity Filter in ClC Chloride Channels
Dutzler, R., Campbell, E. B., & MacKinnon, R. (2003) · Science · doi:10.1126/science.1082708 · Cited by 727
The ABC protein turned chloride channel whose failure causes cystic fibrosis
Gadsby, D. C., Vergani, P., & Csanády, L. (2006) · Nature · doi:10.1038/nature04712 · Cited by 726
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness
Karet, F. E., Finberg, K. E., Nelson, R. D., Nayır, A., Mocan, H. N., Sanjad, S. A., Rodríguez‐Soriano, J., Santos, F., Cremers, C. W. R. J., Pietro, A. D., et al. (1999) · Nature Genetics · doi:10.1038/5022 · Cited by 687

Show all 93 references

Sorted by citations

Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies
Ulbrich, K., Holá, K., Šubr, V., Bakandritsos, A., Tuček, J., & Zbořil, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00589 · Cited by 1,759
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
Settembre, C., Fraldi, A., Medina, D. L., & Ballabio, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3565 · Cited by 1,755
Molecular definitions of autophagy and related processes
Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796697 · Cited by 1,646
Lysosomes as dynamic regulators of cell and organismal homeostasis
Ballabio, A., & Bonifacino, J. S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0185-4 · Cited by 1,469
Lysosomal Physiology
Xu, H., & Ren, D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071649 · Cited by 1,067
Discerning the Chemistry in Individual Organelles with Small‐Molecule Fluorescent Probes
Xu, W., Zeng, Z., Jiang, J., Chang, Y., & Yuan, L. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510721 · Cited by 808
Lysosomal membrane permeabilization and cell death
Wang, F., Gómez‐Sintes, R., & Boya, P. (2018) · Traffic · doi:10.1111/tra.12613 · Cited by 804
The lysosome: from waste bag to potential therapeutic target
Appelqvist, H., Wäster, P., Kågedal, K., & Öllinger, K. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt022 · Cited by 772
Lysosomes as a therapeutic target
Bonam, S. R., Wang, F., & Muller, S. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0036-1 · Cited by 786
Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency
Li, Z., Lai, X., Fu, S., Ren, L. F., Cai, H., Zhang, H., Gu, Z., Ma, X., & Luo, K. (2022) · Advanced Science · doi:10.1002/advs.202201734 · Cited by 704
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
Abu-Remaileh, M., Wyant, G. A., Kim, C., Laqtom, N. N., Abbasi, M., Chan, S. H., Freinkman, E., & Sabatini, D. M. (2017) · Science · doi:10.1126/science.aan6298 · Cited by 680
The Lysosome as a Regulatory Hub
Perera, R. M., & Zoncu, R. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125125 · Cited by 698
β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway
Ghosh, S., Dellibovi-Ragheb, T. A., Kerviel, A., Pak, E., Qiu, Q., Fisher, M., Takvorian, P. M., Bleck, C. K. E., Hsu, V. W., Fehr, A. R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.039 · Cited by 628
pH in nature, humans and skin
Proksch, E. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14489 · Cited by 596
Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors
Hua, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00524 · Cited by 527
Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease
Colacurcio, D. J., & Nixon, R. A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.004 · Cited by 548
siRNA Delivery Strategies: A Comprehensive Review of Recent Developments
Tatiparti, K., Sau, S., Kashaw, S. K., & Iyer, A. K. (2017) · Nanomaterials · doi:10.3390/nano7040077 · Cited by 444
Recent progress in development of siRNA delivery vehicles for cancer therapy
Kim, H. J., Kim, A., Miyata, K., & Kataoka, K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.011 · Cited by 429
The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422
Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19
Yang, N., & Shen, H. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.45498 · Cited by 412
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
Zhou, J., Tan, S.-H., Nicolas, V., Bauvy, C., Yang, N., Zhang, J., Xue, Y., Codogno, P., & Shen, H. (2013) · Cell Research · doi:10.1038/cr.2013.11 · Cited by 397
Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
Lee, J.-H., McBrayer, M. K., Wolfe, D. M., Haslett, L. J., Kumar, A., Sato, Y., Lie, P. P. Y., Mohan, P., Coffey, E. E., Kompella, U., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.050 · Cited by 358
Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification
Wolfe, D. M., Lee, J., Kumar, A. R., Lee, S., Orenstein, S. J., & Nixon, R. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12169 · Cited by 360
Hydroxychloroquine in systemic lupus erythematosus (SLE)
Ponticelli, C. E., & Moroni, G. L. (2016) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2017.1269168 · Cited by 353
Intracellular delivery of nanomaterials: How to catch endosomal escape in the act
Martens, T., Remaut, K., Demeester, J., Smedt, S. C. D., & Braeckmans, K. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.011 · Cited by 342
At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy
Shen, H., & Mizushima, N. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.001 · Cited by 341
Targeted protein degradation: advances in drug discovery and clinical practice
Zhong, G., Chang, X., Xie, W., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02004-x · Cited by 326
A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
Khandia, R., Dadar, M., Munjal, A. K., Dhama, K., Karthik, K., Tiwari, R., Yatoo, M. I., Iqbal, H. M. N., Singh, K. P., Joshi, S. K., et al. (2019) · Cells · doi:10.3390/cells8070674 · Cited by 337
A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro
Wei, H., Chen, J., Wang, S., Fu, F., Zhu, X., Wu, C., Liu, Z., Zhong, G., & Lin, J. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s218988 · Cited by 317
Lysosomal Biology and Function: Modern View of Cellular Debris Bin
Trivedi, P. C., Bartlett, J. J., & Pulinilkunnil, T. (2020) · Cells · doi:10.3390/cells9051131 · Cited by 309
Cancer-associated lysosomal changes: friends or foes?
Kallunki, T., Olsen, O. D., & Jäättelä, M. (2012) · Oncogene · doi:10.1038/onc.2012.292 · Cited by 301
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Settembre, C., & Perera, R. M. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00676-x · Cited by 303
Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy
Wang, R., Li, X., & Yoon, J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c02019 · Cited by 299
RETRACTED ARTICLE: A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
Li, F., Lu, J. G., Liu, J., Liang, C., Wang, M., Wang, L., Li, D., Yao, H., Zhang, Q., Wen, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01565-6 · Cited by 280
Retracted
The elements of life and medicines
Chellan, P., & Sadler, P. J. (2015) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2014.0182 · Cited by 287
Manganese‐Based Layered Double Hydroxide Nanoparticles as a T1‐MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity
Li, B., Gu, Z., Kurniawan, N. D., Chen, W., & Xu, Z. P. (2017) · Advanced Materials · doi:10.1002/adma.201700373 · Cited by 261
Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
Hu, M., Li, P., Wang, C., Feng, X., Geng, Q., Chen, W., Marthi, M., Zhang, W., Gao, C., Reid, W., et al. (2022) · Cell · doi:10.1016/j.cell.2022.05.021 · Cited by 254
Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery
Fan, W., Xia, D., Zhu, Q., Li, X., He, S., Zhu, C., Guo, S., Hovgaard, L., Yang, M., & Gan, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.022 · Cited by 247
Autophagy in age-related macular degeneration
Kaarniranta, K., Błasiak, J., Liton, P. B., Boulton, M. E., Klionsky, D. J., & Sinha, D. (2022) · Autophagy · doi:10.1080/15548627.2022.2069437 · Cited by 250
In situ self-assembly for cancer therapy and imaging
Kim, J., Lee, S., Kim, Y., Choi, M., Lee, I., Kim, E., Yoon, C. G., Pu, K., Kang, H., & Kim, J. S. (2023) · Nature Reviews Materials · doi:10.1038/s41578-023-00589-3 · Cited by 248
Structure and Roles of V-type ATPases
Vasanthakumar, T., & Rubinstein, J. L. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.12.007 · Cited by 242
Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Root, J. T., Merino, P., Nuckols, A., Johnson, M. A., & Kukar, T. L. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105360 · Cited by 243
Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species‐dependent ferroptosis
Wang, Z., Ma, J., Li, X., Wu, Y., Shi, H., Chen, Y., Lu, G. X., Shen, H., Lu, G., & Zhou, J. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15350 · Cited by 236
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation
Weber, R. A., Yen, F. S., Nicholson, S. P. V., Alwaseem, H., Bayraktar, E. C., Alam, M., Timson, R. C., La, K., Abu-Remaileh, M., Molina, H., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.01.003 · Cited by 236
The challenges of oral drug delivery via nanocarriers
Reinholz, J., Landfester, K., & Mailänder, V. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1501119 · Cited by 237
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
Yambire, K. F., Rostosky, C. M., Watanabe, T., Pacheu‐Grau, D., Torres-Odio, S., Sanchez-Guerrero, A., Senderovich, O., Meyron‐Holtz, E. G., Milošević, I., Frahm, J., et al. (2019) · eLife · doi:10.7554/elife.51031 · Cited by 232
The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases
Song, Q., Meng, B., Xu, H., & Mao, Z. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00196-0 · Cited by 244
TMEM175 Is an Organelle K+ Channel Regulating Lysosomal Function
Cang, C., Aranda, K., Seo, Y.-J., Gasnier, B., & Ren, D. (2015) · Cell · doi:10.1016/j.cell.2015.08.002 · Cited by 239
Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model
Avrahami, L., Farfara, D., Shaham-Kol, M., Vassar, R. J., Frenkel, D., & Eldar-Finkelman, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.409250 · Cited by 235
A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells
Saha, S., Prakash, V., Halder, S., Chakraborty, K., & Krishnan, Y. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.130 · Cited by 226
Life in the lumen: The multivesicular endosome
Grüenberg, J. (2019) · Traffic · doi:10.1111/tra.12715 · Cited by 225
Lysosomal cell death mechanisms in aging
Gómez-Sintes, R., Ledesma, M. D., & Boya, P. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.02.009 · Cited by 216
Chloride in Vesicular Trafficking and Function
Stauber, T., & Jentsch, T. J. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183702 · Cited by 219
Autophagy as a modulator of cell death machinery
Noguchi, M., Hirata, N., Tanaka, T., Suizu, F., Nakajima, H., & Chiorini, J. A. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2724-5 · Cited by 223
Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome
Kortüm, F., Caputo, V., Bauer, C. K., Stella, L., Ciolfi, A., Alawi, M., Bocchinfuso, G., Flex, E., Paolacci, S., Dentici, M. L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3282 · Cited by 211
Regulation and function of V-ATPases in physiology and disease
Collins, M. P., & Forgac, M. D. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183341 · Cited by 214
Cellular Proteostasis in Neurodegeneration
Kurtishi, A., Rosen, B., Patil, K. S., Alves, G. W., & Møller, S. G. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1334-z · Cited by 210
A metal-free nanozyme-activated prodrug strategy for targeted tumor catalytic therapy
Liang, Q. Y., Xi, J., Gao, X. J., Zhang, R., Yang, Y., Gao, X., Yan, X., Gao, L., & Fan, K. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100935 · Cited by 204
Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease
Serrano‐Puebla, A., & Boya, P. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12966 · Cited by 204
The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
Garrity, A. G., Wang, W., Collier, C. M., Levey, S. A., Gao, Q., & Xu, H. (2016) · eLife · doi:10.7554/elife.15887 · Cited by 209
Lysosomal size matters
de Araújo, M. E. G., Liebscher, G., Hess, M. W., & Huber, L. A. (2019) · Traffic · doi:10.1111/tra.12714 · Cited by 210
Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology
Yang, J., Griffin, A. S., Qiang, Z., & Ren, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01243-0 · Cited by 224
Bacterial Vesicle Secretion and the Evolutionary Origin of the Eukaryotic Endomembrane System
Gould, S. B., Garg, S. G., & Martin, W. F. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.03.005 · Cited by 196
A model of lysosomal pH regulation
Ishida, Y., Nayak, S., Mindell, J. A., & Grabe, M. (2013) · The Journal of General Physiology · doi:10.1085/jgp.201210930 · Cited by 195
Self-citation
Smart Electrospun Nanofibers for Controlled Drug Release: Recent Advances and New Perspectives
Weng, L., & Xie, J. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150302151959 · Cited by 193
“Dual-Key-and-Lock” Ruthenium Complex Probe for Lysosomal Formaldehyde in Cancer Cells and Tumors
Liu, C., Zhang, R., Zhang, W., Liu, J., Wang, Y., Du, Z., Song, B., Xu, Z. P., & Yuan, J. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b13898 · Cited by 192
Lysosomal Iron, Iron Chelation, and Cell Death
Terman, A., & Kurz, T. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4885 · Cited by 192
A Multifunctional Nanomicelle for Real‐Time Targeted Imaging and Precise Near‐Infrared Cancer Therapy
Tian, J., Ding, L., Ju, H., Yang, Y., Li, X., Shen, Z., Zhu, Z., Yu, J., & Yang, C. J. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201405490 · Cited by 191
Engineering the drug carrier biointerface to overcome biological barriers to drug delivery
Finbloom, J. A., Sousa, F., Stevens, M. M., & Desai, T. A. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.007 · Cited by 195
Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells
Song, X.-B., Liu, G., Liu, F., Yan, Z., Wang, Z., Liu, Z., & Wang, L. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.262 · Cited by 187
Principles and functions of metabolic compartmentalization
Bar‐Peled, L., & Kory, N. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00645-2 · Cited by 194
Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans
Cezairliyan, B. O., Vinayavekhin, N., Lee, D. G., Yuen, G. J., Saghatelian, A., & Ausubel, F. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003101 · Cited by 177
Molecular and cellular pathways contributing to brain aging
Zia, A., Pourbagher‐Shahri, A. M., Farkhondeh, T., & Samarghandian, S. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00179-9 · Cited by 195
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes
Tanaka, Y., Suzuki, G., Matsuwaki, T., Hosokawa, M., Serrano, G. E., Beach, T. G., Yamanouchi, K., Hasegawa, M., & Nishihara, M. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx011 · Cited by 172
The influence of lysosomal stability of silver nanomaterials on their toxicity to human cells
Setyawati, M. I., Yuan, X. F., Xie, J., & Leong, D. T. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.007 · Cited by 179
Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin
Yang, N., Tan, S.-H., Ng, S., Shi, Y. P., Zhou, J., Tan, K. S. W., Wong, W. S. F., & Shen, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.564567 · Cited by 175
Lysosomal Dysfunction and α‐Synuclein Aggregation in Parkinson's Disease: Diagnostic Links
Moors, T. E., Paciotti, S., Chiasserini, D., Calabresi, P., Parnetti, L., Beccari, T., & van de Berg, W. D. J. (2016) · Movement Disorders · doi:10.1002/mds.26562 · Cited by 181
Lysosomal Ion Channels as Decoders of Cellular Signals
Li, P., Gu, M., & Xu, H. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.10.006 · Cited by 178
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders
HOOK, V. Y. H., Yoon, M. C., Mosier, C., Ito, G., Podvin, S., Head, B. P., Rissman, R. A., O’Donoghue, A. J., & Hook, G. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140428 · Cited by 177
Brain Disorders Due to Lysosomal Dysfunction
Fraldi, A., Klein, A. D., Medina, D. L., & Settembre, C. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014031 · Cited by 173
Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms
Sun, Y., & Davis, E. W. (2021) · Nanomaterials · doi:10.3390/nano11030746 · Cited by 183
Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes
Liu, D., Jin, F., Shu, G., Xu, X., Qi, J., Kang, X., Yu, H., Lu, K., Jiang, S., Han, F., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.04.034 · Cited by 169
Ratiometric Fluorescent Probe for Lysosomal pH Measurement and Imaging in Living Cells Using Single-Wavelength Excitation
Liu, X., Su, Y., Tian, H., Yang, L., Zhang, H., Song, X., & Foley, J. W. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00754 · Cited by 170
Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)
Jiang, Y., Sato, Y., Im, E., Berg, M., Bordi, M., Darji, S., Kumar, A., Mohan, P. S., Bandyopadhyay, U., Diaz, A., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0578-19.2019 · Cited by 166
Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation
Jacquin, É., Leclerc‐Mercier, S., Judon, C., Blanchard, E., Fraitag, S., & Florey, O. (2017) · Autophagy · doi:10.1080/15548627.2017.1287653 · Cited by 168
Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice
Klein, Z. A., Takahashi, H., Ma, M., Stagi, M., Zhou, M. S., Lam, T. T., & Strittmatter, S. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.026 · Cited by 162
Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders
Plotegher, N., & Duchen, M. R. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.12.003 · Cited by 161
The Lysosome Signaling Platform: Adapting With the Times
Inpanathan, S., & Botelho, R. J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00113 · Cited by 160
The voltage-gated sodium channel TPC1 confers endolysosomal excitability
Cang, C., Bekele, B., & Ren, D. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1522 · Cited by 168
Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy
Yang, N., Ding, Y., Zhang, Y., Wang, B., Zhao, X., Cheng, K., Huang, Y., Taleb, M., Zhao, J. T., Dong, W., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b05363 · Cited by 164
The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production
Kobayashi, T., Shimabukuro-Demoto, S., Yoshida-Sugitani, R., Furuyama-Tanaka, K., Karyu, H., Sugiura, Y., Shimizu, Y., Hosaka, T., Goto, M., Kato, N., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.08.011 · Cited by 158
Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation
Tsunemi, T., & Krainc, D. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt572 · Cited by 161
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease
Eaton, A. F., Merkulova, M., & Brown, D. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00442.2020 · Cited by 165
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
Bagh, M. B., Peng, S., Chandra, G., Zhang, Z., SINGH, S. P., Pattabiraman, N., Liu, A., & Mukherjee, A. B. (2017) · Nature Communications · doi:10.1038/ncomms14612 · Cited by 163
Delivery of MicroRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux in Vitro and in Vivo
Nguyen, M.-A., Wyatt, H., Susser, L., Geoffrion, M., Rasheed, A., Duchez, A., Cottee, M. L., Afolayan, E., Farah, E., Kahiel, Z., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b09679 · Cited by 158
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
Zhang, J., Zeng, W., Han, Y., Lee, W.-R., Liou, J., & Jiang, Y. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.06.004 · Cited by 163
Lysosomes in senescence and aging
Tan, J. X., & Finkel, T. (2023) · EMBO Reports · doi:10.15252/embr.202357265 · Cited by 178
DNA Logic Operations in Living Cells Utilizing Lysosome-Recognizing Framework Nucleic Acid Nanodevices for Subcellular Imaging
Du, Y., Peng, P., & Li, T. (2019) · ACS Nano · doi:10.1021/acsnano.9b01324 · Cited by 152
Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
Choy, C. H., Saffi, G. T., Gray, M. A., Wallace, C. T., Dayam, R. M., Ou, Z.-Y. A., Lenk, G. M., Puertollano, R., Watkins, S. C., & Botelho, R. J. (2018) · Journal of Cell Science · doi:10.1242/jcs.213587 · Cited by 147
Hyperacidification of Vacuoles by the Combined Action of Two Different P-ATPases in the Tonoplast Determines Flower Color
Faraco, M., Spelt, C. E., Bliek, M., Verweij, W., Hoshino, A., Espen, L., Prinsi, B., Jaarsma, R., Tarhan, E., BOER, A. H. D., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.009 · Cited by 153

Authors: Mindell, J. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Mindell, Joseph A.
ORCID: Mindell, Joseph A.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2012-03-17
Volume: 74
Issue: 1
Pages: 69-86
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev-physiol-012110-142317
OpenAlex: W2000678720
Cited by: 1,258
References: 93
Citations by year: 2026: 99 · 2025: 123 · 2024: 133 · 2023: 106 · 2022: 109 · 2021: 113 · 2020: 106 · 2019: 112 · 2018: 83 · 2017: 76 · 2016: 69 · 2015: 51 · 2014: 40 · 2013: 31 · 2012: 5
FWCI: 2.21
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: lysosomal acidification, lysosomal pH, V-type ATPase, proton translocation, counterion transport, ClC-7, cation transport, endocytic pathway, pH control
MeSH terms: Animals, Biotransformation, Cations, Humans, Hydrogen-Ion Concentration, Ions, Lysosomes, Chloride Channels, Cystic Fibrosis Transmembrane Conductance Regulator, Vacuolar Proton-Translocating ATPases, Electrophysiological Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lysosomal Acidification Mechanisms

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks