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The Role of Gut Hormone Peptide YY in Energy and Glucose Homeostasis: Twelve Years On
Open accessAbstract
Although the role of peptide YY (PYY) as a regulator of energy homeostasis was first highlighted only in 2002, our understanding of the physiological role of PYY has since rapidly advanced. In recent years, insights from mechanistic studies in patients undergoing bariatric surgery, from pancreatic islet research, from functional neuroimaging studies, and from exercise research have greatly added to the field, and these areas provide the focus of discussion for this narrative review. We critically discuss recent findings relating to the role of PYY in mediating the beneficial effects of bariatric surgery, the role of PYY in glucose homeostasis, the role of hepatoportal PYY in mediating its central physiological effects, the specific modulation of brain regions by PYY, and the exercise-induced PYY response.
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“total PYY which includes both PYY 1-36 and PYY 3-36 , reported by Manning and Batterham (2014) to have divergent actions on appetite.”
From Influence of water-based exercise on energy intake, appetite, and appetite-related hormones in adults: A systematic review and meta-analysis (2023) · cites this paper as Manning and Batterham (2014)
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Gut hormone PYY3-36 physiologically inhibits food intake
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Metadata
- Authors
- Manning, S., & Batterham, R. L.
- Affiliations
- University College Hospital (GB)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2014-02-10
- Volume
- 76
- Issue
- 1
- Pages
- 585-608
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2169329075
- Cited by
- 124
- References
- 150
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 6 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 11 · 2014: 4
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- peptide YY, energy homeostasis, glucose homeostasis, bariatric surgery, pancreatic islets, central nervous system, brain regions, physical activity, gastrointestinal hormones
- MeSH terms
- Adult, Animals, Energy Metabolism, Female, Glucose, Homeostasis, Humans, Male, Obesity, Weight Loss, Exercise, Peptide YY, Bariatric Surgery
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