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The Role of Gut Hormone Peptide YY in Energy and Glucose Homeostasis: Twelve Years On
Open accessAbstract
Although the role of peptide YY (PYY) as a regulator of energy homeostasis was first highlighted only in 2002, our understanding of the physiological role of PYY has since rapidly advanced. In recent years, insights from mechanistic studies in patients undergoing bariatric surgery, from pancreatic islet research, from functional neuroimaging studies, and from exercise research have greatly added to the field, and these areas provide the focus of discussion for this narrative review. We critically discuss recent findings relating to the role of PYY in mediating the beneficial effects of bariatric surgery, the role of PYY in glucose homeostasis, the role of hepatoportal PYY in mediating its central physiological effects, the specific modulation of brain regions by PYY, and the exercise-induced PYY response.
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“total PYY which includes both PYY 1-36 and PYY 3-36 , reported by Manning and Batterham (2014) to have divergent actions on appetite.”
From Influence of water-based exercise on energy intake, appetite, and appetite-related hormones in adults: A systematic review and meta-analysis (2023) · cites this paper as Manning and Batterham (2014)
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Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Self-citationKRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977
Sjöström, L. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12012 · Cited by 1,835
Metabolic/Bariatric Surgery Worldwide 2011
Buchwald, H., & Oien, D. M. (2013) · Obesity Surgery · doi:10.1007/s11695-012-0864-0 · Cited by 1,698
Inhibition of Food Intake in Obese Subjects by Peptide YY 3–36
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604
Self-citationLong-term persistence of hormonal adaptations to weight loss
Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A., & Proietto, J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105816 · Cited by 1,449
Roux, C. W. L., Aylwin, S. J. B., Batterham, R. L., Borg, C. M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M. A., Patel, A. G., & Bloom, S. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000183349.16877.84 · Cited by 985
Self-citationEllingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922
Karamanakos, S. N., Vagenas, K., Kalfarentzos, F. E., & Alexandrides, T. K. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e318156f012 · Cited by 831
Kringelbach, M. L. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1064 · Cited by 824
Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass
le Roux, C. W., Welbourn, R., Werling, M., Osborne, A., Kokkinos, A., Laurenius, A., Lönroth, H., Fändriks, L., Ghatei, M. A., Bloom, S. R., et al. (2007) · Annals of Surgery · doi:10.1097/sla.0b013e3180caa3e3 · Cited by 741
Mechanick, J. I., Youdim, A., Jones, D. B., Garvey, W. T., Hurley, D. L., McMahon, M. M., Heinberg, L. J., Kushner, R. F., Adams, T. D., Shikora, S. A., et al. (2013) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.12.010 · Cited by 715
Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior
Malik, S., McGlone, F., Bedrossian, D., & Dagher, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.007 · Cited by 677
Critical role for peptide YY in protein-mediated satiation and body-weight regulation
Batterham, R. L., Heffron, H., Kapoor, S., Chivers, J. E., Chandarana, K., Herzog, H., le Roux, C. W., Thomas, E. L., Bell, J. D., & Withers, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.08.001 · Cited by 653
Self-citationIncretin-based therapies for type 2 diabetes mellitus
Lovshin, J. A., & Drucker, D. J. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.48 · Cited by 645
The role of gut hormones in glucose homeostasis
Drucker, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30076 · Cited by 628
The Hormonal Control of Food Intake
Coll, A. P., Farooqi, I. S., & O’Rahilly, S. (2007) · Cell · doi:10.1016/j.cell.2007.04.001 · Cited by 624
Tatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2514 · Cited by 615
Attenuated Peptide YY Release in Obese Subjects Is Associated with Reduced Satiety
le Roux, C. W., Batterham, R. L., Aylwin, S. J. B., Patterson, M., Borg, C.-M., Wynne, K., Kent, A. S. H., Vincent, R. P., Gardiner, J., Ghatei, M. A., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0972 · Cited by 562
Self-citationMetabolic and hedonic drives in the neural control of appetite: who is the boss?
Berthoud, H. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.004 · Cited by 543
Peterli, R., Steinert, R. E., Wölnerhanssen, B. K., Peters, T. T. A., Christoffel-Courtin, C., Gass, M., Kern, B. E., von Fluee, M., & Beglinger, C. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0622-3 · Cited by 531
Wu, T., Gao, X., Chen, M., & Van Dam, R. M. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00547.x · Cited by 515
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
Batterham, R. L., Ffytche, D. H., Rosenthal, J., Zelaya, F. O., Barker, G. J., Withers, D. J., & Williams, S. (2007) · Nature · doi:10.1038/nature06212 · Cited by 489
Self-citationKorner, J., Bessler, M., Cirilo, L. J., Conwell, I. M., Daud, A., Restuccia, N. L., & Wardlaw, S. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1076 · Cited by 417
Sleeve Gastrectomy — A Restrictive Procedure?
Melissas, J., Koukouraki, S., Askoxylakis, J., Stathaki, M., Daskalakis, M., Perisinakis, K., & Karkavitsas, N. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9006-5 · Cited by 402
Morínigo, R., Moizé, V., Musri, M., Lacy, A. M., Navarro, S., Marín, J. L., Delgado, S., Casamitjana, R., & Vidal, J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0904 · Cited by 397
Habib, A. M., Richards, P., Cairns, L. S., Rogers, G. J., Bannon, C. A. M., Parker, H. E., Morley, T. C. E., Yeo, G. S. H., Reimann, F. M., & Gribble, F. M. (2012) · Endocrinology · doi:10.1210/en.2011-2170 · Cited by 382
CD26: A Multifunctional Integral Membrane and Secreted Protein of Activated Lymphocytes
Gorrell, M. D., Gysbers, V., & McCaughan, G. W. (2001) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2001.00984.x · Cited by 366
Grandt, D., Schimiczek, M., Beglinger, C., Layer, P., Goebell, H., Eysselein, V. E., & Reeve, J. R. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90204-6 · Cited by 363
Silva, A. D., Salem, V., Long, C. J., Makwana, A., Newbould, R. D., Rabiner, E. A., Ghatei, M. A., Bloom, S. R., Matthews, P. M., Beaver, J. D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.010 · Cited by 358
Effects of exercise on gut peptides, energy intake and appetite
Martins, C., Morgan, L., Bloom, S. R., & Robertson, M. D. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0030 · Cited by 356
Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV
Mentlein, R., Dahms, P., Grandt, D., & Krüger, R. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90435-b · Cited by 349
Egerod, K. L., Engelstoft, M. S., Grunddal, K. V., Nøhr, M. K., Secher, A., Sakata, I., Pedersen, J., Windeløv, J. A., Füchtbauer, E., Olsen, J., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1595 · Cited by 345
Jacobsen, S. H., Olesen, S. C., Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Worm, D., Almdal, T., Naver, L. S., Hvolris, L. E., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0621-4 · Cited by 342
Korner, J., Inabnet, W., Febres, G., Conwell, I. M., McMahon, D. J., Salas, R., Taveras, C., Schrope, B., & Bessler, M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.79 · Cited by 338
King, N. A., Burley, V. J., & Blundell, J. E. (1994) · PubMed · Cited by 327
Borg, C.-M., le Roux, C. W., Ghatei, M. A., Bloom, S. R., Patel, A. G., & Aylwin, S. J. B. (2006) · British journal of surgery · doi:10.1002/bjs.5227 · Cited by 325
Broom, D. R., Batterham, R. L., King, J. A., & Stensel, D. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90706.2008 · Cited by 325
Self-citationDoes gut hormone PYY3–36 decrease food intake in rodents?
Tschöp, M., Castañeda, T. R., Joost, H., Thöne‐Reineke, C., Ortmann, S., Klaus, S., Hagan, M., Chandler-Laney, P. C., Oswald, K. D., Benoit, S. C., et al. (2004) · Nature · doi:10.1038/nature02665 · Cited by 295
Strader, A. D., Vahl, T. P., Jandacek, R. J., Woods, S. C., D’Alessio, D. A., & Seeley, R. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00153.2004 · Cited by 295
Speakman, J. R., Levitsky, D. A., Allison, D. B., Bray, M. S., de Castro, J. M., Clegg, D. J., Clapham, J. C., Dulloo, A. G., Gruer, L., Haw, S., et al. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.008698 · Cited by 290
All Bariatric Surgeries Are Not Created Equal: Insights from Mechanistic Comparisons
Stefater, M. A., Wilson, H., Chambers, A. P., Sandoval, D. A., & Seeley, R. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1044 · Cited by 289
Sleeve Gastrectomy—A “Food Limiting” Operation
Melissas, J., Daskalakis, M., Koukouraki, S. I., Askoxylakis, I., Metaxari, M., Dimitriadis, E., Stathaki, M. I., & Papadakis, J. A. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9634-4 · Cited by 279
Sloth, B., Holst, J. J., Flint, A., Gregersen, N. T., & Astrup, A. V. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00450.2006 · Cited by 250
G-Protein-Coupled Receptors in Intestinal Chemosensation
Reimann, F. M., Tolhurst, G., & Gribble, F. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.019 · Cited by 245
Differential Effects of Gastric Bypass and Banding on Circulating Gut Hormone and Leptin Levels
Korner, J., Inabnet, W., Conwell, I. M., Taveras, C., Daud, A., Olivero‐Rivera, L., Restuccia, N. L., & Bessler, M. (2006) · Obesity · doi:10.1038/oby.2006.179 · Cited by 240
The Effects of Exercise-Induced Weight Loss on Appetite-Related Peptides and Motivation to Eat
Martins, C., Kulseng, B., King, N. A., Holst, J. J., & Blundell, J. E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2082 · Cited by 236
Effects of PYY[3–36] in rodent models of diabetes and obesity
Pittner, R. A., Moore, C. X., Bhavsar, S., Gedulin, B. R., Smith, P. A., Jodka, C. M., Parkes, D. G., Paterniti, J. R., Srivastava, V. P., & Young, A. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802696 · Cited by 223
The regulation of food intake by the gut-brain axis: implications for obesity
Hussain, S., & Bloom, S. R. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.93 · Cited by 204
Incretin and islet hormonal responses to fat and protein ingestion in healthy men
Carr, R. D., Larsen, M. O., Winzell, M. S., Jelic, K., Lindgren, O., Deacon, C. F., & Åhrén, B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90233.2008 · Cited by 202
Characterization of Blood-Brain Barrier Permeability to PYY3-36 in the Mouse
Nonaka, N., Shioda, S., Niehoff, M. L., & Banks, W. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051821 · Cited by 201
Gibbons, C., Caudwell, P., Finlayson, G., Webb, D., Hellström, P. M., Näslund, E. B., & Blundell, J. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3835 · Cited by 201
Ueda, S.-Y., Yoshikawa, T., Katsura, Y., Usui, T., Nakao, H., & Fujimoto, S. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0500 · Cited by 192
Abbott, C. R., Small, C. J., Kennedy, A. R., Neary, N. M., Sajedi, A., Ghatei, M. A., & Bloom, S. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.065 · Cited by 191
Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity
Näslund, E. B., Grybäck, P., Hellström, P. M., Jacobsson, H., Holst, J. J., Theodorsson, E., & Bäckman, L. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800418 · Cited by 190
Upchurch, B. H., Aponte, G. W., & Leiter, A. B. (1994) · Development · doi:10.1242/dev.120.2.245 · Cited by 190
Plamboeck, A., Veedfald, S., Deacon, C. F., Hartmann, B., Wettergren, A., Svendsen, L. B., Meisner, S., Hovendal, C. P., Vilsbøll, T., Knop, F. K., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00035.2013 · Cited by 189
Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity
Boey, D., Lin, S., Karl, T., Baldock, P., Lee, N., Enriquez, R., Couzens, M., Slack, K., Dallmann, R., Sainsbury, A., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0237-0 · Cited by 186
Habib, A. M., Richards, P., Rogers, G. J., Reimann, F. M., & Gribble, F. M. (2013) · Diabetologia · doi:10.1007/s00125-013-2887-z · Cited by 184
Dirksen, C., Damgaard, M., Bojsen‐Møller, K. N., Jørgensen, N. B., Kielgast, U., Jacobsen, S. H., Naver, L. S., Worm, D., Holst, J. J., Madsbad, S., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12087 · Cited by 184
Ramón, J. M., Salvans, S., Crous, X., Puig, S., Goday, A., Benaiges, D., Trillo, L., Pera, M., & Grande, L. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-1855-0 · Cited by 182
Perry, J. L., Joseph, J. E., Jiang, Y., Zimmerman, R. S., Kelly, T. H., Darna, M., Huettl, P., Dwoskin, L. P., & Bardo, M. T. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.09.001 · Cited by 180
Ueda, S.-Y., Yoshikawa, T., Katsura, Y., Usui, T., & Fujimoto, S. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0190 · Cited by 178
Changes in Eating Behaviour and Meal Pattern Following Roux-En-Y Gastric Bypass
Laurenius, A., Larsson, I., Bueter, M., Melanson, K. J., Bosaeus, I., Forslund, H. B., Lönroth, H., Fändriks, L., & Olbers, T. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.217 · Cited by 174
Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety
Belza, A., Ritz, C., Sørensen, M. Q., Holst, J. J., Rehfeld, J. F., & Astrup, A. V. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.047563 · Cited by 171
Exercise, Appetite and Appetite-Regulating Hormones: Implications for Food Intake and Weight Control
Stensel, D. (2010) · Annals of Nutrition and Metabolism · doi:10.1159/000322702 · Cited by 171
Deighton, K., Barry, R., Connon, C. E., & Stensel, D. J. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2535-1 · Cited by 165
King, J. A., Wasse, L. K., Ewens, J., Crystallis, K., Emmanuel, J. J., Batterham, R. L., & Stensel, D. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2735 · Cited by 159
Self-citationCarr, R. D., Larsen, M. O., Jelic, K., Lindgren, O., Vikman, J., Holst, J. J., Deacon, C. F., & Åhrén, B. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2054 · Cited by 154
Basso, N., Capoccia, D., Rizzello, M., Abbatini, F., Mariani, P., Maglio, C., Coccia, F., Borgonuovo, G., Luca, M. L. D., Asprino, R., et al. (2011) · Surgical Endoscopy · doi:10.1007/s00464-011-1755-5 · Cited by 148
Diet and Gastrointestinal Bypass–Induced Weight Loss
Chandarana, K., Gelegen, Ç., Karra, E., Choudhury, A. I., Drew, M. E., Fauveau, V., Viollet, B., Andréelli, F., Withers, D. J., & Batterham, R. L. (2011) · Diabetes · doi:10.2337/db10-0566 · Cited by 148
Self-citationMumphrey, M. B., Patterson, L. M., Zheng, H., & Berthoud, H. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12034 · Cited by 147
Long-Term Persistence of Hormonal Adaptations to Weight Loss
Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A. D., & Proietto, J. (2012) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e318247c6f7 · Cited by 134
Effect of Macronutrient Composition on Postprandial Peptide YY Levels
Essah, P. A., Levy, J. R., Sistrun, S. N., Kelly, S. M., & Nestler, J. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2273 · Cited by 133
PYY3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet
van den Hoek, A. M., Heijboer, A. C., Corssmit, E. P. M., Voshol, P. J., Romijn, J. A., Havekes, L. M., & Pijl, H. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1949 · Cited by 127
Peptide YY Is Secreted after Oral Glucose Administration in a Gender-Specific Manner
Kim, B.-J., Carlson, O. D., Jang, H.-J., Elahi, D., Berry, C., & Egan, J. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0409 · Cited by 122
Long‐term Exercise Training in Overweight Adolescents Improves Plasma Peptide YY and Resistin
Jones, T. E., Basilio, J. L., Brophy, P. M., McCammon, M. R., & Hickner, R. C. (2009) · Obesity · doi:10.1038/oby.2009.11 · Cited by 122
Peptide YY Levels Are Elevated After Gastric Bypass Surgery
Chan, J. L., Mun, E. C., Stoyneva, V., Mantzoros, C. S., & Goldfine, A. B. (2006) · Obesity · doi:10.1038/oby.2006.25 · Cited by 114
Guelfi, K. J., Donges, C. E., & Duffield, R. (2012) · Metabolism · doi:10.1016/j.metabol.2012.08.002 · Cited by 113
Pilichiewicz, A. N., Little, T. J., Brennan, I. M., Meyer, J. H., Wishart, J. M., Otto, B., Horowitz, M., & Feinle‐Bisset, C. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00606.2005 · Cited by 108
Effect of Weight Loss by Diet or Gastric Bypass Surgery on Peptide YY3–36 Levels
Oliván, B., Teixeira, J. A., Bose, M., Bawa, B., Chang, T. C., Summe, H., Lee, H., & Laferrère, B. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181a6cdb0 · Cited by 104
Goumain, M., Voisin, T., Lorinet, A.-M., & Laburthe, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8647 · Cited by 104
Sloth, B., Davidsen, L., Holst, J. J., Flint, A., & Astrup, A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00153.2007 · Cited by 104
Bose, M., Machineni, S., Oliván, B., Teixeira, J., McGinty, J. J., Bawa, B., Koshy, N., Colarusso, A., & Laferrère, B. (2010) · Obesity · doi:10.1038/oby.2009.473 · Cited by 102
Scott, W. R., & Batterham, R. L. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2011 · Cited by 101
Self-citationInfluence of Running and Walking on Hormonal Regulators of Appetite in Women
Larson‐Meyer, D. E., Palm, S. M., Bansal, A., Austin, K. J., Hart, A. M., & Alexander, B. M. (2012) · Journal of Obesity · doi:10.1155/2012/730409 · Cited by 96
Mechanisms underlying the rapid degradation and elimination of the incretin hormones GLP-1 and GIP
Mentlein, R. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.03.005 · Cited by 94
Valderas, J. P., Verónica Irribarra, P., Boza, C., de la Cruz, R., Yéssica Liberona, Z., Acosta, A. M., Yolito, M., & Alberto Maiz, G. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0983 · Cited by 92
The gut endocrine system as a coordinator of postprandial nutrient homoeostasis
Gribble, F. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000705 · Cited by 92
Chandarana, K., Drew, M. E., Emmanuel, J. J., Karra, E., Gelegen, Ç., Chan, P., Cron, N., & Batterham, R. L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.047 · Cited by 89
Self-citationDiabetes remission after bariatric surgery: is it just the incretins?
Laferrère, B. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.143 · Cited by 88
Peptide YY Regulates Bone Remodeling in Mice: A Link between Gut and Skeletal Biology
Wong, I. P. L., Drießler, F., Khor, E. C., Shi, Y., Hörmer, B. A., Nguyen, A., Enriquez, R. F., Eisman, J. A., Sainsbury, A., Herzog, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040038 · Cited by 87
Morı́nigo, R., Vidal, J., Lacy, A. M., Delgado, S., Casamitjana, R., & Gomis, R. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e31815f6e77 · Cited by 86
Walther, C., Mörl, K., & Beck‐Sickinger, A. G. (2011) · Journal of Peptide Science · doi:10.1002/psc.1357 · Cited by 85
Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY
Unniappan, S., McIntosh, C. H. S., Demuth, H. U., Heiser, U. F., Wolf, R., & Kieffer, T. J. (2006) · Diabetologia · doi:10.1007/s00125-006-0310-8 · Cited by 83
Werling, M., Olbers, T., Fändriks, L., Bueter, M., Lönroth, H., Stenlöf, K., & le Roux, C. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060280 · Cited by 83
Effects of acute exercise on appetite hormones and ad libitum energy intake in men and women
Hagobian, T. A., Yamashiro, M., Hinkel-Lipsker, J., Streder, K., Evero, N., & Hackney, T. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0104 · Cited by 83
The Gut Hormone Response Following Roux-en-Y Gastric Bypass: Cross-sectional and Prospective Study
Pournaras, D. J., Osborne, A., Hawkins, S. C., Mahon, D., Ghatei, M. A., Bloom, S. R., Welbourn, R., & le Roux, C. W. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9989-1 · Cited by 82
Deighton, K., Karra, E., Batterham, R. L., & Stensel, D. J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0484 · Cited by 81
Self-citationEffects of different modes of exercise on appetite and appetite-regulating hormones
Kawano, H., Mineta, M., Asaka, M., Miyashita, M., Numao, S., Gando, Y., Ando, T., Sakamoto, S., & Higuchi, M. (2013) · Appetite · doi:10.1016/j.appet.2013.01.017 · Cited by 80
Selective Ablation of Peptide YY Cells in Adult Mice Reveals Their Role in Beta Cell Survival
Sam, A. H., Gunner, D. J., King, A., Persaud, S. J., Brooks, L. J., Hostomska, K., Ford, H. E., Liu, B., Ghatei, M. A., Bloom, S. R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.047 · Cited by 79
The role of peptide YY in regulating glucose homeostasis
Boey, D., Sainsbury, A., & Herzog, H. (2007) · Peptides · doi:10.1016/j.peptides.2006.07.031 · Cited by 77
Peptide YY: intrapancreatic localization and effects on insulin and glucagon secretion in the mouse.
Böttcher, G., Åhrén, B., Lundquist, I., & Sundler, F. (1989) · PubMed · Cited by 70
Ortiz, A. A., Milardo, L. F., DeCarr, L. B., Buckholz, T. M., Mays, M. R., Claus, T. H., Livingston, J. N., Mahle, C. D., & Lumb, K. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125211 · Cited by 69
Kirino, Y., Sei, M., Kawazoe, K., Minakuchi, K., & Sato, Y. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0158 · Cited by 68
Appetite regulation via exercise prior or subsequent to high-fat meal consumption
Cheng, M. H.-Y., Bushnell, D., Cannon, D. T., & Kern, M. (2009) · Appetite · doi:10.1016/j.appet.2008.09.015 · Cited by 68
Boey, D., Heilbronn, L. K., Sainsbury, A., Laybutt, D. R., Kriketos, A. D., Herzog, H., & Campbell, L. V. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.08.002 · Cited by 68
Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance
Chandarana, K., Gelegen, Ç., Irvine, E. E., Choudhury, A. I., Amouyal, C., Andréelli, F., Withers, D. J., & Batterham, R. L. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.03.001 · Cited by 66
Self-citationBöttcher, G., Åhrén, B., Lundquist, I., & Sundler, F. (1989) · Pancreas · doi:10.1097/00006676-198906000-00002 · Cited by 64
Gueugnon, C., Mougin, F., Nguyen, N. U., Bouhaddi, M., Nicolet-Guénat, M., & Dumoulin, G. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2154-2 · Cited by 61
Ghrelin and PYY in the regulation of energy balance and metabolism: lessons from mouse mutants
Kirchner, H., Tong, J., Tschöp, M. H., & Pfluger, P. T. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00191.2009 · Cited by 59
Characterization of brainstem peptide YY (PYY) neurons
Glavas, M. M., Grayson, B. E., Allen, S. E., Copp, D. R., Smith, M. S., Cowley, M. A., & Grove, K. L. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21543 · Cited by 59
Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
Burcelin, R., Brunner, H. R., Seydoux, J., Thorensa, B., & Pedrazzini, T. (2001) · Peptides · doi:10.1016/s0196-9781(01)00357-6 · Cited by 59
Exercise and ghrelin. A narrative overview of research
King, J. A., Wasse, L. K., Stensel, D. J., & Nimmo, M. A. (2013) · Appetite · doi:10.1016/j.appet.2013.04.018 · Cited by 58
Kelly, K. R., Brooks, L. M., Solomon, T. P. J., Kashyap, S., O’Leary, V. B., & Kirwan, J. P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00112.2009 · Cited by 58
Wang, L., Gourcerol, G., Yuan, P., Wu, S. V., Million, M., Larauche, M. H., & Taché, Y. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00349.2009 · Cited by 55
Effect of bypassing the proximal gut on gut hormones involved with glycemic control and weight loss
Pournaras, D. J., Aasheim, E. T., Bueter, M., Ahmed, A. R., Welbourn, R., Olbers, T., & le Roux, C. W. (2012) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.01.021 · Cited by 54
Ghitza, U. E., Nair, S. G., Golden, S. A., Gray, S. M., Uejima, J. L., Bossert, J. M., & Shaham, Y. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5405-06.2007 · Cited by 53
Cooper, J. A., Watras, A. C., Paton, C. M., Wegner, F. H., Adams, A., & Schoeller, D. A. (2010) · Appetite · doi:10.1016/j.appet.2010.10.009 · Cited by 53
Fenske, W. K., Bueter, M., Miras, A. D., Ghatei, M. A., Bloom, S. R., & le Roux, C. W. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.126 · Cited by 52
Effects of surgical manipulation of the intestine on peptide YY and its physiology
Imamura, M. (2002) · Peptides · doi:10.1016/s0196-9781(01)00618-0 · Cited by 50
Central and peripheral regulation of gastric acid secretion by peptide YY
Yang, H. (2002) · Peptides · doi:10.1016/s0196-9781(01)00611-8 · Cited by 48
Tam, C. S., Berthoud, H., Bueter, M., Chakravarthy, M. V., Geliebter, A., Hajnal, A. S., Holst, J. J., Kaplan, L. M., Pories, W. J., Raybould, H. E., et al. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00902.x · Cited by 47
Patel, R. T., Shukla, A. P., Ahn, S. M., Moreira, M., & Rubino, F. (2013) · Obesity · doi:10.1002/oby.20441 · Cited by 46
Lessons Learned from Gastric Bypass Operations in Rats
Seyfried, F., le Roux, C. W., & Bueter, M. (2011) · Obesity Facts · doi:10.1159/000327301 · Cited by 45
Possible Mechanisms of Circulating PYY-Induced Satiation in Male Rats
Weber‐Stadlbauer, U., Arnold, M., Weber, E., & Langhans, W. (2012) · Endocrinology · doi:10.1210/en.2012-1956 · Cited by 44
Dumont, Y., Moyse, E., Fournier, A., & Quirion, R. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-9007-9 · Cited by 43
Shedding pounds after going under the knife: Metabolic insights from cutting the gut
Chandarana, K., & Batterham, R. L. (2012) · Nature Medicine · doi:10.1038/nm.2748 · Cited by 41
Self-citationMechanisms underlying the insulinostatic effect of peptide YY in mouse pancreatic islets
Nieuwenhuizen, A. G., Karlsson, S., Fridolf, T., & Ahr�n, B. (1994) · Diabetologia · doi:10.1007/bf00400941 · Cited by 39
Gaining New Insights into Food Reward with Functional Neuroimaging
Neary, M. T., & Batterham, R. L. (2009) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000264403 · Cited by 38
Self-citationSatiety, but not total PYY, Is increased with continuous and intermittent exercise
Holmstrup, M. E., Fairchild, T. J., Keslacy, S., Weinstock, R. S., & Kanaley, J. A. (2013) · Obesity · doi:10.1002/oby.20335 · Cited by 38
Chelikani, P. K., Shah, I. H., Taqi, E., Sigalet, D. L., & Koopmans, H. H. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0139-6 · Cited by 37
Alam, M. L., der Schueren, B. V., Åhrén, B., Wang, G. C., Swerdlow, N. J., Arias, S., Bose, M., Gorroochurn, P., Teixeira, J. A., McGinty, J., et al. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01358.x · Cited by 35
Tsilchorozidou, T., Batterham, R. L., & Conway, G. S. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03285.x · Cited by 34
Self-citationPeptide YY does not inhibit glucose-stimulated insulin secretion in humans
Åhrén, B., & Larsson, H. (1996) · European Journal of Endocrinology · doi:10.1530/eje.0.1340362 · Cited by 30
Fernández‐García, J. C., Murri, M., Coín‐Aragüez, L., Alcaide, J., Bekay, R. E., & Tinahones, F. J. (2013) · Clinical Endocrinology · doi:10.1111/cen.12221 · Cited by 30
Chandarana, K., & Batterham, R. L. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f3f4b1 · Cited by 28
Self-citationFeedback regulation of pancreatic secretion by peptide YY
Naruse, S., Kitagawa, M., Ishiguro, H., & Hayakawa, T. (2002) · Peptides · doi:10.1016/s0196-9781(01)00612-x · Cited by 28
Effects of endurance running and dietary fat on circulating ghrelin and peptide YY.
Russel, R. R., Willis, K. S., Ravussin, É., & Larson‐Meyer, E. (2009) · Europe PMC (PubMed Central) · Cited by 26
Ukkola, O. H., Puurunen, V.-P., Piira, O.-P., Niva, J., Lepojärvi, E. S., Tulppo, M. P., & Huikuri, H. V. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.05.006 · Cited by 26
Incretin-based Therapies for Type 2 Diabetes
McIntosh, C. H. S. (2008) · Canadian Journal of Diabetes · doi:10.1016/s1499-2671(08)22010-1 · Cited by 24
Heden, T. D., Liu, Y., Sims, L. J., Kearney, M. L., Whaley‐Connell, A. T., Chockalingam, A., Dellsperger, K. C., Fairchild, T. J., & Kanaley, J. A. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-0884 · Cited by 20
Shedding pounds after going under the knife: Guts over glory—why diets fail
Larder, R., & O’Rahilly, S. (2012) · Nature Medicine · doi:10.1038/nm.2747 · Cited by 19
Weise, C. M., Thiyyagura, P., Reiman, E. M., Chen, K., & Krakoff, J. A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.023 · Cited by 16
Gelegen, Ç., Chandarana, K., Choudhury, A. I., Al‐Qassab, H., Evans, I. M., Irvine, E. E., Hyde, C., Claret, M., Andréelli, F., Sloan, S. E., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00033.2012 · Cited by 16
Self-citationBuchan, A. M. J., Pederson, R. A., Koop, I., Gourlay, R. H., & Cleator, I. G. M. (1993) · PubMed · Cited by 15
Hill, B. R., Souza, M. J. D., Wagstaff, D. A., Sato, R., & Williams, N. I. (2012) · Peptides · doi:10.1016/j.peptides.2012.08.017 · Cited by 12
Neuroimaging the interaction of mind and metabolism in humans
D’Agostino, A. E., & Small, D. M. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.06.002 · Cited by 11
The Dynamic Incretin Adaptation and Type 2 Diabetes
Åhrén, B. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0299 · Cited by 6
Feedback regulation of pancreatic secretion.
Fushiki, T., Tsuzuki, S., Pierzynowski, S. G., & Zabielski, R. (1999) · Cited by 5
Research works printed but not linked: 6
- Buchan AM, 1993, Int. J. Obes. Relat. Metab. Disord., 17, 109
- 97. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, et al. 2002. Gut hormone PYY3-36 physiologically inhibits food intake. 418:650–54 · DOI · Paper page
- 10.1056/NEJMoa030204 · DOI · Paper page
- 10.1152/ajpendo.00450.2006 · DOI
- King NA, 1994, Eur. J. Clin. Nutr., 48, 715
- Russel RR, 2009, J. Sports Sci. Med., 8, 574
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Self-citation
Metadata
- Authors
- Manning, S., & Batterham, R. L.
- Affiliations
- University College Hospital (GB)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2014-02-10
- Volume
- 76
- Issue
- 1
- Pages
- 585-608
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2169329075
- Cited by
- 124
- References
- 150
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 6 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 11 · 2014: 4
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- peptide YY, energy homeostasis, glucose homeostasis, bariatric surgery, pancreatic islets, central nervous system, brain regions, physical activity, gastrointestinal hormones
- MeSH terms
- Adult, Animals, Energy Metabolism, Female, Glucose, Homeostasis, Humans, Male, Obesity, Weight Loss, Exercise, Peptide YY, Bariatric Surgery
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