The Osteocyte: New Insights

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Shimada, T., Kakitani, M., Yamazaki, Y., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419081 · Cited by 1,368

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/er.21.2.115 · Cited by 1,318

Matrix-embedded cells control osteoclast formation

Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199

Sensitivity of osteocytes to biomechanical stress in vitro

Klein‐Nulend, J., van der Plas, A., Semeins, C. M., Ajubi, N. E., Erangos, J. A., Nijweide, P. J., & Burger, E. H. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.5.7896017 · Cited by 776

Non-physiological direction loading increases bone adaptive responses by enhancing lacunocanalicular fluid dynamics

Wang, Y., Fu, R., & Yang, H. (2025) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjaf117 · Cited by 1

Decoding the regulatory role of noncoding RNAs in biological and vascular calcification

Lamba, J. K., Tandon, S., & Tandon, C. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11086-x · Cited by 1

Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology

Mazur, C. M., Kotsalidis, P. E., George, M. A., Whalley, T., Sato, T., Doench, J. G., Surface, L. E., & Wein, M. N. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113075 · Cited by 1

Lipocalin-2 upregulation in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesis

Narita, K., Ohori, F., Marahleh, A., Ma, J., Ren, J., Lin, A., Fan, Z., Murakami, K., & Kitaura, H. (2026) · Scientific Reports · doi:10.1038/s41598-025-34575-2 · Cited by 1

Modulating Galectin-1 in human osteoblast-like cells alters mineralisation and influences the expression of genes associated with osteoblasts and osteocytes

Ross, A. C., Feddersen, L., Dudhia, J., Psifidi, A., & Guest, D. J. (2026) · Bioscience Reports · doi:10.1042/bsr20253890 · Cited by 1

Modulation of tocotrienol’s bone effects by osteocytes: a perspective

Zahanordin, N. N., Ng, P. H. O., & Chin, K. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1773544 · Cited by 1

In vitro and in vivo osteogenic cell response to high temperature exposure

Хлусов, И. А., Nasibov, T. F., Gorokhova, A. V., Porokhova, E. D., Kokorev, O. V., Leshenkova, A. V., Ryzhkova, A., Pakhmurin, D. O., Anisenya, I. I., Sitnikov, P. K., et al. (2026) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2026-1-113-130 · Cited by 1

Genomic structural equation modeling reveals the shared genetic architecture of osteosarcopenia across five musculoskeletal phenotypes

Lai, W., Gong, K., Zhong, R., Yin, W., Li, X., 黄, 和., Hu, S., Chen, C. Z., He, K., Sun, C., et al. (2026) · Mammalian Genome · doi:10.1007/s00335-026-10245-0 · Cited by 1

Targeting the Gpr125-Gper1 axis: a novel osteogenic signaling pathway with therapeutic potential against osteoporosis

Tang, C.-Y., Han, Y.-X., Wu, H., Jiang, H., Wen, Y., He, Q., Liu, Y., Liu, H., Feng, G., Luo, Y.-F., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08337-1 · Cited by 1

The mechano-immune-vesicle regulatory circuit: a systems framework for bone homeostasis and regeneration

Yang, T., Dong, Z., Chen, L., & Kou, X. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.05.050 · Cited by 1

Sex specific effects of irisin on the skeleton

Shimonty, A., & Bonewald, L. F. (2026) · Bone Research · doi:10.1038/s41413-026-00542-4 · Cited by 1

Rewiring osteoimmune homeostasis in osteoporosis: T-cell subsets as key regulators and emerging therapeutic targets

Gong, Y., Zeng, W., Liao, Y., Xie, X., Qin, Z., Li, C., & Zhang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1926935 · Cited by 1

Treadmill exercise induced differential miRNA expression in mouse femoral exosomes and upregulated osteogenesis-related miRNAs

Yu, H., Wang, Y., Han, B., Liu, L., Li, Y., Du, H., & Guo, Y. (2026) · Connective Tissue Research · doi:10.1080/03008207.2026.2720437 · Cited by 1

Silymarin Effects on Ovine Fetal Bone Marrow-Derived Mesenchymal Stem Cells Differentiation into Osteogenic Lineage

Morovati, I., Mohammadi, T., Pooyanmehr, M., & Soltani, L. (2022) · Cell & Tissue Journal · doi:10.52547/jct.13.2.135 · Cited by 1

Large scale analysis of osteocyte lacunae in klotho hypomorphic mice using high-resolution micro-computed tomography

Ahmed, F., Minamizaki, T., Kohno, S., Aubin, J. E., Kharaghani, D., Hoshino, T., & Yoshiko, Y. (2023) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2023.152142 · Cited by 1

Inflammatory Biomarkers in Periodontitis and Their Effect on the Stem/Progenitor Cells: Molecular Basis of Bone Resorption and Bone Regeneration

Rady, D., Moshy, S. E., Abbass, M. M. S., Sadek, K. M., El‐Rashidy, A. A., Radwan, I. A., & El‐Sayed, K. M. F. (2023) · Springer eBooks · doi:10.1007/978-981-99-0846-2_51-1 · Cited by 1

Wnt pathway in bone: knowledge structure and hot spots from 1993 to 2022

Liu, T., Zhao, J., Zhang, X., Wang, Y., Wang, W., & Song, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1279423 · Cited by 1

Form and Function of Tissues which Undergo Mineralization

Shapiro, I. M., & Landis, W. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-34304-9_3 · Cited by 1

Carbon Nanotubes for Cartilage and Bone Tissue Engineering

Durairaj, S., Roy, H. S., Arora, M., Ahuja, K. K., & Ghosh, D. (2024) · Springer eBooks · doi:10.1007/978-3-031-63961-6_1 · Cited by 1

Emerging roles of osteocytes in the regulation of bone and skeletal muscle mass

Moin, M. R., Das, S., & Sanyal, S. (2024) · Journal of Molecular Endocrinology · doi:10.1530/jme-24-0033 · Cited by 1

Exploring the Interplay Between Senescent Osteocytes and Bone Remodeling in Young Rodents

Song, I., Kim, P.-J., Choi, Y. J., Chung, Y., Lee, S., Baek, J., & Woo, K. M. (2024) · Journal of Aging Research · doi:10.1155/2024/4213141 · Cited by 1

Bone mechanical loading reduces heart rate and increases heart rate variability in mice

Vallejo, J. A., Gray, M., Klump, J., Wacker, A., Dallas, M., Johnson, M. L., & Wacker, M. (2025) · Bone Reports · doi:10.1016/j.bonr.2025.101844 · Cited by 1

Evaluation of the Microstructural Characteristics of Bone Surrounding Anchor Screws Placed under a Horizontal Load by Exploring the Orientation of Biological Apatite Crystals and Collagen Fiber Anisotropy

Matsumoto, T., Matsunaga, S., Kasahara, M., Kasahara, N., Nakano, T., Ishimoto, T., & Nishii, Y. (2022) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.31.79 · Cited by 1

Nonpharmacologic intervention for osteosarcopenia

Waters, D. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820088-9.00007-x · Cited by 1

Notch1 is a marker for in situ resting osteocytes in a 3-dimensional gel culture model

Zhou, Y., Zhu, J., Guo, Y., Tang, H., Wang, F., Iqbal, J., Wu, H., Hu, N., Xiao, F., Wang, T., et al. (2023) · Connective Tissue Research · doi:10.1080/03008207.2023.2217271 · Cited by 1

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesiclesPreprint

Xie, J., Xu, Y., Liu, X., Long, L., Chen, J., Huang, C., Shao, Y., Cai, Z., Zhang, Z., Zhou, R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.14.544869 · Cited by 1

Studies on the role of matrix vesicles in bone mineralization: observations from micro to nanoscale

Cruz, M. A. E. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.59.2023.tde-29062023-144521 · Cited by 1

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesiclesPreprint

Xie, J., Xu, Y., Liu, X., Long, L., Chen, J., Huang, C., Shao, Y., Cai, Z., Zhang, Z., Zhou, R., et al. (2024) · eLife · doi:10.7554/elife.89613.2 · Cited by 1

Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific mannerPreprint

Shimonty, A., Pin, F., Prideaux, M., Peng, G., Huot, J. R., Kim, H., Rosen, C. J., Spiegelman, B. M., & Bonewald, L. F. (2024) · eLife · doi:10.7554/elife.92263.2 · Cited by 1

MASLD and MASH increase fracture risk in humans and mice by arresting new bone formationPreprint

Goldscheitter, G., Jahagirdar, V., Seneshaw, M., Mirshahi, F., Summerlin, M., Ip, A., Coelho, A., Buettmann, E. G., Genetos, D. C., Sanyal, A. J., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7775325/v1 · Cited by 1

Peer Review #1 of "In situ SEM/EDS compositional characterization of osteocytes and blood vessels in fossil and extant turtles on untreated bone surfaces; different preservational pathways microns away (v0.1)"

(2020) · PeerJ · doi:10.7287/peerj.9833v0.1/reviews/1

Bone and growth: basic principles behind rare disorders

Raimann, A., Ertl, D., & Haeusler, G. (2021) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-020-00809-3

Das Knochenmarködemsyndrom

Schmidt, C., Delsmann, M. M., Stürznickel, J., & Barvencik, F. (2021) · Arthritis und Rheuma · doi:10.1055/a-1530-7216

Epigenetics of Osteoporosis

Bischof, O., Ebert, R., Taipaleenmäki, H., Hesse, E., & Jakob, F. J. (2021) · Osteologie/Osteology · doi:10.1055/a-1527-4395

Efeito do alendronato, da dexametasona e da associação de ambos sobre a osteoclastogênese: um estudo in vitro

de Faria, L. P. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.23.2021.tde-27102021-123034

Peer Review #2 of "In situ SEM/EDS compositional characterization of osteocytes and blood vessels in fossil and extant turtles on untreated bone surfaces; different preservational pathways microns away (v0.1)"

(2020) · PeerJ · doi:10.7287/peerj.9833v0.1/reviews/2

Drug therapy for bone metastasis of malignant tumor: theory, progress, and potential.

Tian, J.-Z., Ma, N.-N., Li, X., Shang, K., & Cao, B.-W. (2022) · Neoplasma (Bratislava) · doi:10.4149/neo_2021_211006n1412

Association Between Dietary Selenium Intake and Bone Mineral Density: A Cross-sectional Study Using National Health and Nutrition Examination SurveyPreprint

Xue, G., & Liu, R. (2022) · Research Square · doi:10.21203/rs.3.rs-1506021/v1

Graftless sinus floor augmentation of the highly atrophic posterior maxilla before implant placement

Lie, S. A. N. (2022) · doi:10.26481/dis.20220713sl

Cell Adhesion to the Extracellular Matrix

Geiger, B., Livne, A., & Grosheva, I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00134-6

Serum type I collagen carboxyl-terminal peptide β glypeptide was positively associated with osteoporosis and skeletal muscle lossPreprint

Chen, L., Wu, J., Ren, W., Li, X., Luo, M., & Hu, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1648392/v1

COVID-19 and Osteoporosis: Shared Mechanisms and Crosstalk via Vitamin DPreprint

Liu, F., Song, C., Cai, W., Chen, J., Cheng, K., Guo, D., Duan, D. D., & Liu, Z. (2022) · Research Square · doi:10.21203/rs.3.rs-1887098/v1

Methods for assessing the effectiveness of using bone morphogenetic proteins in spondylodesis

Фаритович, М. У., Владимирович, Л. С., Borzunov, D. Y., & Фанилевич, Г. И. (2022) · HERALD of North-Western State Medical University named after I I Mechnikov · doi:10.17816/mechnikov106089

Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice.Preprint

Plotkin, L. I., Deosthale, P. J., Balanta‐Melo, J., Creecy, A., Liu, C., Marcial, A., Morales, L., Cridlin, J., Robertson, S., Okpara, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2338908/v1

Non-stem Cell Mediated Tissue Regeneration and Repair

Reshamwala, R., Oieni, F., & Shah, M. P. (2023) · Springer eBooks · doi:10.1007/978-981-19-6008-6_2

Natural Polymers and Osteogenic Cells for Bone Tissue Regeneration

Cao, W. (2023) · doi:10.5463/thesis.28

Mechanosensitivity of osteocytes in their native matrix

Zhang, C. (2023) · doi:10.5463/thesis.189

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesiclesPreprint

Xie, J., Xu, Y., Liu, X., Long, L., Chen, J., Shao, Y., Cai, Z., Zhang, Z., Zhou, R., Leng, J., et al. (2023) · eLife · doi:10.7554/elife.89613.1

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Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific mannerPreprint

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Vitamin B3 Rescues Mandibular Osteoporosis in Bmi-1–Deficient Mice by Regulating AutophagyPreprint

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Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific mannerPreprint

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Rescuing SERCA2 pump deficiency: A novel approach to improve bone mechano-responsiveness in type 2 diabetes

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Investigation of the role of strontium on bone physiology: from a molecular biology perspective to applicability

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Research Progress on Oxidative Stress in the Pathogenesis of Steroid-Induced Osteonecrosis of the Femoral Head

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Influence of immunodeficiency on spring-assisted cranioplasty: A study in mice

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Mechanisms of Spinal Metastases: New Perspectives

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Inflammatory Biomarkers in Periodontitis and Their Effect on the Stem/Progenitor Cells: Molecular Basis of Bone Resorption and Bone Regeneration

Rady, D., Moshy, S. E., Abbass, M. M. S., Sadek, K. M., El‐Rashidy, A. A., Radwan, I. A., & El‐Sayed, K. M. F. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_51

Photobiomodulation Effect of Diode Laser on Differentiation of Osteoprogenitor Cells in Rat Bone Marrow

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Osterix Facilitates Osteocytic Communication by Targeting Connexin43Preprint

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The role of bone in energy metabolism

Luo, X., Guo, Q., & Xiong, J. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0261

microRNAs in Bone Disorders

Palmini, G., & Brandi, M. L. (2024) · Endocrinology · doi:10.1007/978-3-030-19632-5_17-1

Muscle-to-Bone Mass Ratio: A Novel Biomarker for Osteoporosis Screening and Fracture Risk Assessment in the ElderlyPreprint

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Osterix Facilitates Osteocytic Communication by Targeting Connexin43Preprint

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Osterix Facilitates Osteocytic Communication by Targeting Connexin43Preprint

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Bone Matrix-forming Tumors

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Mechanism of Astragaloside IV in Promoting Osteogenic Differentiation

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Involvement of icaritin in the regulation of osteocyte exosomal microRNAs

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Jansen's Disease: Bone Abnormalities Beyond Chondrodysplasia

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Underestimated Roles of Osteocytes in Medication-Related Osteonecrosis of the Jaw

Xu, C., & Wu, Y. (2025) · Regenerative medicine and dentistry. · doi:10.53941/rmd.2025.100003

3D Focused Ion Beam Microscopy of Fossilized Albertosaurus sarcophagus reveals Nano to Microscale StructuresPreprint

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A novel optimized silver nitrate staining method for visualizing the osteocyte lacuno-canalicular system

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Nano-Scale Peri-Lacunar Bone Formation and Implications for the Modulation of Whole Bone QualityPreprint

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Research Progress in the Etiology of Primary Osteoporosis

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Intelligent Biomaterials for Organ Regeneration and Tissue Engineering

Liao, Z., Song, J., Zhu, X.-M., Guo, Y., Wang, Y., & Yao, B. (2025) · Springer eBooks · doi:10.1007/978-981-96-8646-9_3

A novel web-based online nomogram was used to predict postoperative function in patients with femoral shaft fractures treated with intramedullary nailsPreprint

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The role of sex and age in some pathobiological and pathophysiological processes

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The Human Osteocyte Lacunocanalicular Network Structure in the Iliac Crest of Post-Menopausal Women Depends on Mineral Content But Not Individual AgePreprint

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Notch signaling modulates Fgf23 expression through crosstalk with hypoxia and PTH pathways in osteogenic cells

Tamamura, Y., Terai, K., & Yamaguchi, A. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112663 · Cited by 1

Phosphates plasmatiques

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Molecular mechanisms and clinical implications of Wnt pathway inhibition

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Depletion of mmu-miR-185 enhances osteocyte connectivity and suppresses bone fragility through the interaction between ARL8B and RAB5A

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