The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Abstract
Short-chain fatty acids (SCFA) are the major anion in stool and are synthesized from nonabsorbed carbohydrate by the colonic microbiota. Nonabsorbed carbohydrate are not absorbed in the colon and induce an osmotically mediated diarrhea; in contrast, SCFA are absorbed by colonic epithelial cells and stimulate Na-dependent fluid absorption via a cyclic AMP–independent process involving apical membrane Na-H, SCFA-HCO 3, and Cl-SCFA exchanges. SCFA production represents an adaptive process to conserve calories, fluid, and electrolytes. Inhibition of SCFA synthesis by antibiotics and administration of PEG, a substance that is not metabolized by colonic microbiota, both result in diarrhea. In contrast, increased production of SCFA as a result of providing starch that is relatively resistant to amylase digestion [so-called resistant starch (RS)] to oral rehydration solution (RS-ORS) improves the efficacy of ORS and represents an important approach to improve the effectiveness of ORS in the treatment of acute diarrhea in children under five years of age.
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“SGLT-1 is expressed primarily in the small intestine with highest density in the jejunum followed by the duodenum and then ileum (39,40).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [40]
Citations
Cites
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Metadata
- Authors
- Binder, H. J.
- Affiliations
- Yale University (US)
- Corresponding author
- Binder, Henry J.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2010-03-17
- Volume
- 72
- Issue
- 1
- Pages
- 297-313
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2166520529
- Cited by
- 315
- References
- 96
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 28 · 2023: 22 · 2022: 27 · 2021: 29 · 2020: 19 · 2019: 27 · 2018: 23 · 2017: 17 · 2016: 20 · 2015: 13 · 2014: 11 · 2013: 19 · 2012: 11
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- short-chain fatty acids, osmotic diarrhea, colonic microbiota, resistant starch, oral rehydration solution, acute diarrhea in children, antibiotics, polyethylene glycol
- MeSH terms
- Cyclic AMP, Animals, Biological Transport, Active, Colon, Diarrhea, Fatty Acids, Volatile, Fluid Therapy, Humans, Intestinal Absorption, Osmotic Pressure, Sodium, Sodium-Hydrogen Exchangers
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