The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Senescence in COPD and Its Comorbidities
Open accessAbstract
Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening, cellular senescence, activation of PI3 kinase-mTOR signaling, impaired autophagy, mitochondrial dysfunction, stem cell exhaustion, epigenetic changes, abnormal microRNA profiles, immunosenescence, and a low-grade chronic inflammation (inflammaging). Many of these pathways are driven by chronic exogenous and endogenous oxidative stress. There is also a reduction in antiaging molecules, such as sirtuins and Klotho, which further accelerate the aging process. COPD is associated with several comorbidities (multimorbidity), such as cardiovascular and metabolic diseases, that share the same pathways of accelerated aging. Understanding these mechanisms has helped identify several novel therapeutic targets, and several drugs and dietary interventions are now in development to treat multimorbidity.
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3 retracted
Evidence for Human Lung Stem Cells
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Cited by
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., & Salvioli, S. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00061 · Cited by 945
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2022) · Inflammation Research · doi:10.1007/s00011-022-01598-8 · Cited by 432
Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke
Hikichi, M., Mizumura, K., Maruoka, S., & Gon, Y. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.10.43 · Cited by 283
Romanello, V., & Sandri, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03662-0 · Cited by 197
Cellular Metabolism in Lung Health and Disease
Liu, G., & Summer, R. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114640 · Cited by 157
Metadata
- Authors
- Barnes, P. J.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2017-02-10
- Volume
- 79
- Issue
- 1
- Pages
- 517-539
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2565550227
- Cited by
- 266
- References
- 153
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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