Cellular Metabolism in Lung Health and Disease
Open accessAbstract
The lung is often overlooked as a metabolically active organ, yet biochemical studies have long demonstrated that glucose utilization surpasses that of many other organs, including the heart, kidney, and brain. For most cells in the lung, energy consumption is relegated to performing common cellular tasks, like mRNA transcription and protein translation. However, certain lung cell populations engage in more specialized types of energy-consuming behaviors, such as the beating of cilia or the production of surfactant. While many extrapulmonary diseases are now linked to abnormalities in cellular metabolism, the pulmonary community has only recently embraced the concept of metabolic dysfunction as a driver of respiratory pathology. Herein, we provide an overview of the major metabolic pathways in the lung and discuss how cells sense and adapt to low-energy states. Moreover, we review some of the emerging evidence that links alterations in cellular metabolism to the pathobiology of several common respiratory diseases.
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Sorted by citations
Fibrosis: from mechanisms to medicines
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Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis
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Self-citation
- Authors
- Liu, G., & Summer, R.
- Affiliations
- University of Alabama at Birmingham (US)
- Thomas Jefferson University (US)
- Corresponding author
- Summer, Ross
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2019-02-10
- Volume
- 81
- Issue
- 1
- Pages
- 403-428
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- PMC
- PMC6853603
- OpenAlex
- W2902994754
- Cited by
- 157
- References
- 138
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 25 · 2023: 21 · 2022: 18 · 2021: 28 · 2020: 9 · 2019: 4
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL126737, R01HL131784, R35HL135830)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- lung metabolism, cellular metabolism, glucose utilization, metabolic dysfunction, respiratory diseases, energy sensing, ciliary beating, surfactant production
- MeSH terms
- Animals, Energy Metabolism, Glycolysis, Humans, Lung, Lung Diseases, Mitochondria, Oxidative Phosphorylation
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