The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Regulation of Insulin Secretion in Human Pancreatic Islets
Abstract
Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β cell is electrically excitable; in response to an elevation of glucose, it depolarizes and starts generating action potentials. The electrophysiology of mouse β cells and the cell's role in insulin secretion have been extensively investigated. More recently, similar studies have been performed on human β cells. These studies have revealed numerous and important differences between human and rodent β cells. Here we discuss the properties of human pancreatic β cells: their glucose sensing, the ion channel complement underlying glucose-induced electrical activity that culminates in exocytotic release of insulin, the cellular control of exocytosis, and the modulation of insulin secretion by circulating hormones and locally released neurotransmitters. Finally, we consider the pathophysiology of insulin secretion and the interactions between genetics and environmental factors that may explain the current diabetes epidemic.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The primary secretory pathway of glucose-stimulated insulin secretion is associated with complex patterns of electrical activity across the plasma membrane, which allow Ca2+ ions to enter the cell and trigger the secretory machinery.”
From Mathematical Modelling of Endocrine Systems (2019) · cites this paper as [11]
In the citing paper
“This electrical activity is coupled to cell metabolism, which acts as a glucose sensor by raising the intracellular ATP:ADP ratio, causing KATP channels to close, depolarising the membrane and driving it towards its threshold for action potential initiation [11].”
From Mathematical Modelling of Endocrine Systems (2019) · cites this paper as [11]
In the citing paper
“Adrenaline and somatostatin lead to transient repolarization and suppression of glucose-induced electrical activity (327, 568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The action potentials of human β-cells are also triggered from a more negative membrane potential in human than in mouse β-cells (-60 mV rather than -50 to -40 mV) and often overshoot, peaking at potentials above zero mV (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The action potentials of both mouse and human β-cells are short, ranging between 5 ms (human) and 30-40 ms (mouse) (568, 570).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Thus, delayed rectifying K+ channels may not activate much during the human β-cell action potential, which lasts only ~5 ms (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Blocking SK channels with apamin, or the non-selective antagonist NS8593, results in membrane depolarization and action potential firing in human β-cells (311) and stimulates insulin secretion (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Inhibition of inward rectifiers with Ba2+ (0.1 mM) or Cs+ (1 mM) in human β-cells exposed to glucose (6 mM) and tolbutamide (0.1 mM) resulted in membrane depolarization and stimulation of action potential firing (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“These currents were blocked by low concentrations of Ba2+ (100 μM) and Cs+ (1 mM).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The Ba2+-sensitive current displayed strongly inward rectification and reversed at ~-85 mV, which is close to EK.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“In human β-cells, hyperpolarizing voltage steps from a holding potential of -70 mV evoked progressively larger tolbutamide-resistant inward currents (553, 568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Similarly, in human β-cells exposed to 6 mM glucose, carbachol evoked membrane depolarization (~5 mV) and increased action potential firing (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The smallest cell aggregates reported by the authors were ca. 200 microns in diameter; the typical human islet has a diameter of ca. 130 microns176.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [176]
Citations
Cites
Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216
Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., & Rajotte, R. V. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430401 · Cited by 5,237
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
The MAGIC investigators, Voight, B. F., The GIANT Consortium, Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.609 · Cited by 1,761
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
Cabrera, O., Berman, D. M., Kenyon, N. S., Ricordi, C., Berggren, P.-O., & Caicedo, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510790103 · Cited by 1,312
Research works printed but not linked: 3
- Hellman B, 1959, Acta Soc. Med. Ups., 64, 432
- Scheen AJ, 1996, Diabetes Metab., 22, 397
- Clark A, 1988, Diabetes Res., 9, 151
Cited by
Sorted by citations
Items 101–200 of 595
β‐Cell dysfunction in diabetes: a crisis of identity?
Brereton, M. F., Rohm, M., & Ashcroft, F. M. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12732 · Cited by 71
Mathematical models of electrical activity of the pancreatic β-cell: A physiological review
Félix‐Martínez, G. J., & Godínez-Fernández, J. R. (2014) · Islets · doi:10.4161/19382014.2014.949195 · Cited by 67
Neurotransmitter control of islet hormone pulsatility
Gylfe, E., & Tengholm, A. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12345 · Cited by 69
Insulin/adenosine axis linked signalling
Silva, L., Subiabre, M., Henríquez, J. A., Sáez, T., Salsoso, R., Pardo, F., Leiva, A., Martín, R. S., Toledo, F., & Sobrevía, L. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.002 · Cited by 64
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases
Huang, Q.-Y., Lai, X., Qian, X., Lv, L., Li, J., Duan, J., Xiao, X., & Xiong, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010179 · Cited by 67
Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations
Lei, C. L., Kellard, J. A., Hara, M., Johnson, J. D., Rodríguez, B., & Briant, L. J. B. (2018) · Islets · doi:10.1080/19382014.2018.1493316 · Cited by 61
ElAzzouny, M. A., Evans, C. R., Treutelaar, M. K., Kennedy, R. T., & Burant, C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.531970 · Cited by 60
The Difference δ-Cells Make in Glucose Control
Huising, M. O., van der Meulen, T., Huang, J. L., Pourhosseinzadeh, M. S., & Noguchi, G. M. (2018) · Physiology · doi:10.1152/physiol.00029.2018 · Cited by 65
Bi, H., Karanth, S. S., Ye, K., Stein, R., & Jin, S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00088 · Cited by 56
Yang, S.-Y., Lee, J.-J., Lee, J., Lee, K., Oh, S. H., Lim, Y.-M., Lee, M., & Lee, K. (2016) · Biochemical Journal · doi:10.1042/bcj20160137 · Cited by 58
The role of beta cell heterogeneity in islet function and insulin release
Nasteska, D., & Hodson, D. J. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0011 · Cited by 61
Salunkhe, V. A., Esguerra, J. L. S., Ofori, J. K., Mollet, I. G., Braun, M., Stoffel, M., Wendt, A., & Eliasson, L. (2015) · Acta Physiologica · doi:10.1111/apha.12460 · Cited by 56
Self-citationPHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Roles for insulin-supported skeletal muscle growth1,2
Rhoads, R. P., Baumgard, L. H., El‐Kadi, S. W., & Zhao, L. D. (2016) · Journal of Animal Science · doi:10.2527/jas.2015-0110 · Cited by 56
Optical Nanosensors for Real‐Time Feedback on Insulin Secretion by β‐Cells
Ehrlich, R., Hendler‐Neumark, A., Wulf, V., Amir, D., & Bisker, G. (2021) · Small · doi:10.1002/smll.202101660 · Cited by 56
Li, Z., Tian, J., Cheng, Z., Teng, W., Zhang, W., Bao, Y., Wang, Y., Song, B., Chen, Y., & Li, B. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2055526 · Cited by 58
Kristinsson, H., Sargsyan, E., Manell, H., Smith, D. M., Göpel, S., & Bergsten, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-04730-5 · Cited by 56
Metabolic roles of G protein‐coupled receptor signaling in obesity and type 2 diabetes
Barella, L. F., Jain, S., Kimura, T., & Pydi, S. P. (2021) · FEBS Journal · doi:10.1111/febs.15800 · Cited by 61
Hyperglycemia Is Associated with Psoriatic Inflammation in Both Humans and Mice
Ikumi, K., Odanaka, M., Shime, H., Imai, M., Osaga, S., Taguchi, O., Nishida, E., Hemmi, H., Kaisho, T., Morita, A., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.01.029 · Cited by 55
Wu, T., Zhang, S., Xu, J., Zhang, Y., Sun, T., Shao, Y., Wang, J., Tang, W., Chen, F., & Han, X. (2020) · Diabetes · doi:10.2337/db19-1060 · Cited by 54
Metabolism and Health Impacts of Dietary Sugars
Alam, Y. H., Kim, R., & Jang, C. (2022) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2022.11.1.20 · Cited by 54
Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes
Sukumaran, A., Choi, K., & Dasgupta, B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00671 · Cited by 62
Wassmer, C., Lebreton, F., Bellofatto, K., Bosco, D., Berney, T., & Berishvili, E. (2020) · Transplant International · doi:10.1111/tri.13721 · Cited by 58
Irles, E., Ñeco, P., Lluesma, M., Villar-Pazos, S., Santos-Silva, J. C., Vettorazzi, J. F., Alonso‐Magdalena, P., Carneiro, E. M., Boschero, A. C., Nadal, Á., et al. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.033 · Cited by 53
Single Fluorescent Protein-Based Indicators for Zinc Ion (Zn2+)
Chen, Z., & Ai, H. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b01653 · Cited by 52
Castiello, F. R., & Tabrizian, M. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04288 · Cited by 55
From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion
Yang, J., Lü, J., Yuan, S., Asan, Cao, X., Qiu, H.-Y., Shi, T., Yang, F., Li, Q., Liu, C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.12.005 · Cited by 55
The supply chain of human pancreatic β cell lines
Scharfmann, R., Staels, W., & Albagli, O. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129484 · Cited by 54
Castiello, F. R., Heileman, K., & Tabrizian, M. (2015) · Lab on a Chip · doi:10.1039/c5lc01046b · Cited by 61
Gunasekar, S. K., Xie, L., Kumar, A., Hong, J., Chheda, P. R., Chen, K., Kern, D. M., My-Ta, C., Maurer, J. M., Heebink, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28435-0 · Cited by 51
Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells
Lebreton, F., Pirog, A., Belouah, I., Bosco, D., Berney, T., Meda, P., Bornat, Y., Catargi, B., Renaud, S., Raoux, M., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3558-z · Cited by 59
Sorrenson, B., Cognard, E., Lee, K. L., Dissanayake, W. C., Fu, Y., Han, W., Hughes, W. E., & Shepherd, P. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.758516 · Cited by 53
Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction
Fu, J., Dai, X.-Q., Plummer, G., Suzuki, K., Bautista, A., Githaka, J. M., Senior, L., Jensen, M. V., Greitzer-Antes, D., Fox, J. E. M., et al. (2017) · Diabetes · doi:10.2337/db16-1170 · Cited by 56
Bioelectronic organ-based sensor for microfluidic real-time analysis of the demand in insulin
Perrier, R., Pirog, A., Jaffredo, M., Gaitan, J., Catargi, B., Renaud, S., Raoux, M., & Lang, J. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.06.015 · Cited by 57
β- cell dynamics in type 2 diabetes and in dietary and exercise interventions
Lv, C.-A., Sun, Y., Zhang, Z. Y., Aboelela, Z., Qiu, X., & Meng, Z. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac046 · Cited by 57
Ning, S., Zheng, W., Su, J., Liang, N., Li, H. Z., Zhang, D., Liu, C., Dong, J., Zhang, Z., Cui, M., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13271 · Cited by 49
Yu, Q., Canales, A., Glover, M. S., Das, R., Shi, X., Liu, Y., Keller, M. P., Attie, A., & Li, L. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b01926 · Cited by 50
Xu, J., Wang, L., Tang, J., Jia, G., Liu, G., Chen, X., Cai, J., Shang, H., & Zhao, H. Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182079 · Cited by 53
The Insulin:Glucagon Ratio and the Choice of Glucose-Lowering Drugs
Kalra, S., & Gupta, Y. (2016) · Diabetes Therapy · doi:10.1007/s13300-016-0160-4 · Cited by 49
Metabolic Regulation of Insulin Secretion
Keane, K. N., & Newsholme, P. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800174-5.00001-6 · Cited by 52
Investigational insulin secretagogues for type 2 diabetes
Scheen, A. J. (2016) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2016.1152260 · Cited by 49
Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs
Esguerra, J. L. S., Mollet, I. G., Salunkhe, V., Wendt, A., & Eliasson, L. (2014) · Genes · doi:10.3390/genes5041018 · Cited by 46
Song, W., Mondal, P., Li, Y., Lee, S. E., & Hussain, M. A. (2013) · Diabetes · doi:10.2337/db12-1394 · Cited by 46
Pancreatic islet organoids-on-a-chip: how far have we gone?
Yin, J., Meng, H., Lin, J., Ji, W., Xu, T., & Liu, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01518-2 · Cited by 48
Proverbio, M. C., Mangano, E., Gessi, A., Bordoni, R., Spinelli, R., Asselta, R., Valin, P. S., Candia, S. D., Zamproni, I., Diceglie, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068740 · Cited by 48
Hastoy, B., Godazgar, M., Clark, A., Nylander, V., Spiliotis, I., van de Bunt, M., Chibalina, M., Barrett, A., Burrows, C., Tarasov, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34743-7 · Cited by 42
Self-citationRocha, S., Lucas, M., Ribeiro, D., Corvo, M. L., Fernandes, E. G. R., & Freitas, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105604 · Cited by 47
Replacing and safeguarding pancreatic β cells for diabetes
Bruin, J. E., Rezania, A., & Kieffer, T. J. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa9359 · Cited by 45
The role of adherens junction proteins in the regulation of insulin secretion
Dissanayake, W. C., Sorrenson, B., & Shepherd, P. R. (2018) · Bioscience Reports · doi:10.1042/bsr20170989 · Cited by 42
Pedersen, M. G., Tagliavini, A., & Henquin, J. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2018 · Cited by 43
Hatamie, A., Ren, L., Dou, H., Gandasi, N. R., Rorsman, P., & Ewing, A. G. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202015902 · Cited by 44
Self-citationA pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell
Maheshvare, M. D., Raha, S., König, M., & Pal, D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1185656 · Cited by 56
Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes
Masini, M., Marselli, L., Bugliani, M., Martino, L., Masiello, P., Marchetti, P., & Tata, V. D. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0446-6 · Cited by 42
Tian, G., Sol, E.-R. M., Xu, Y., Shuai, H., & Tengholm, A. (2014) · Diabetes · doi:10.2337/db14-1036 · Cited by 44
MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells
Richards, P., Rachdi, L., Oshima, M., Marchetti, P., Bugliani, M., Armanet, M., Postic, C., Guilmeau, S., & Scharfmann, R. (2017) · Diabetes · doi:10.2337/db17-0595 · Cited by 44
Ahn, C., Kang, H.-S., Lee, J., Hong, E., Jung, E., Yoo, Y., & Jeung, E. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.06.1071 · Cited by 43
Ninagawa, S., Tada, S., Okumura, M., Inoguchi, K., Kinoshita, M., Kanemura, S., Imami, K., Umezawa, H., Ishikawa, T., Mackin, R. B., et al. (2020) · eLife · doi:10.7554/elife.60970 · Cited by 45
GLP-1R Signaling and Functional Molecules in Incretin Therapy
Wan, W., Qin, Q., Xie, L., Zhang, H., Wu, F., Stevens, R. C., & Liu, Y. (2023) · Molecules · doi:10.3390/molecules28020751 · Cited by 44
Zhang, Y., Lü, J., Li, H., & Song, H. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2293254 · Cited by 42
Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes
Nieves, A. M. R., Wauford, B. M., & Fu, A. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1354199 · Cited by 52
Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets
Almaça, J., Liang, T., Gaisano, H. Y., Nam, H. G., Berggren, P., & Caicedo, A. (2015) · Diabetologia · doi:10.1007/s00125-015-3747-9 · Cited by 44
Cairano, E. S. D., Moretti, S., Marciani, P., Sacchi, V. F., Castagna, M., Davalli, A. M., Folli, F. B., & Perego, C. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25176 · Cited by 48
Kim, M.-J., Park, S.-K., Lee, J., Jung, C.-Y., Sung, D. J., Park, J.-H., Yoon, Y.-S., Park, J., Park, K., Song, D., et al. (2015) · Diabetes · doi:10.2337/db14-1240 · Cited by 42
Human islet function following 20 years of cryogenic biobanking
Fox, J. E. M., Lyon, J., Dai, X.-Q., Wright, R. C., Hayward, J. A., van de Bunt, M., Kin, T., Shapiro, A. M. J., McCarthy, M., Gloyn, A., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3598-4 · Cited by 44
Channelopathies, painful neuropathy, and diabetes: which way does the causal arrow point?
Hoeijmakers, J. G. J., Faber, C. G., Merkies, I. S. J., & Waxman, S. G. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.06.003 · Cited by 42
Mathematical modeling of gap junction coupling and electrical activity in human β -cells
Loppini, A., Braun, M., Filippi, S., & Pedersen, M. G. (2015) · Physical Biology · doi:10.1088/1478-3975/12/6/066002 · Cited by 39
Self-citationGap junction proteins are key drivers of endocrine function
Meda, P. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.03.005 · Cited by 42
Wu, Y., Fortin, D. A., Cochrane, V. A., Chen, P., & Shyng, S. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.802249 · Cited by 45
A role for taste receptors in (neuro)endocrinology?
Behrens, M., & Meyerhof, W. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12691 · Cited by 41
Cabrera, O., FICORILLI, J. V., Shaw, J., Echeverri, F., Schwede, F., Chepurny, O. G., Leech, C. A., & Holz, G. G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101484 · Cited by 42
Chen, Y., Yang, F., Chu, Y., Yun, Z., Yan, Y., & Jin, J. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03693-0 · Cited by 41
Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans
Esguerra, J. L. S., & Eliasson, L. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00209 · Cited by 41
de Graaf‐Roelfsema, E. (2013) · The Veterinary Journal · doi:10.1016/j.tvjl.2013.09.064 · Cited by 43
Perillo, M., & Arnone, M. I. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.06.014 · Cited by 40
Ang, S. Y., Hutchinson, D. S., Patil, N. A., Evans, B. A., Bathgate, R. A. D., Halls, M. L., Hossain, M. A., Summers, R. J., & Kočan, M. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13522 · Cited by 38
Koutsouras, D. A., Perrier, R., Marquez, A. V., Pirog, A., Pedraza, E., Cloutet, É., Renaud, S., Raoux, M., Malliaras, G. G., & Lang, J. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.07.028 · Cited by 45
Kamiya, K., Osaki, T., Nakao, K., Kawano, R., Fujii, S., Misawa, N., Hayakawa, M., & Takeuchi, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-35316-4 · Cited by 40
Emerging Roles of Small GTPases in Islet β-Cell Function
Veluthakal, R., & Thurmond, D. C. (2021) · Cells · doi:10.3390/cells10061503 · Cited by 44
Schrell, A. M., Mukhitov, N., Yi, L., Adablah, J. E., Menezes, J., & Roper, M. G. (2016) · Analytical Methods · doi:10.1039/c6ay02899c · Cited by 40
Beta‐Cell Ion Channels and Their Role in Regulating Insulin Secretion
Thompson, B. M., & Satin, L. S. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210004 · Cited by 57
Zhao, S., Shi, C. Y., Hu, H., Li, Z., Xiao, G., Yang, Q., Sun, P., Cheng, L., Niu, W., Bi, J., et al. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.111962 · Cited by 40
Li, X., Feng, L., Kuang, Q., Wang, X., Yang, J., Niu, X., Gao, L., Huang, L., Luo, P., & Li, L. (2023) · Environmental Toxicology · doi:10.1002/tox.24034 · Cited by 40
The pancreatic β cell: recent insights from human genetics
Thomsen, S. K., & Gloyn, A. L. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.05.001 · Cited by 38
Stem cells to insulin secreting cells: two steps forward and now a time to pause?
Kushner, J., Macdonald, P., & Atkinson, M. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.10.012 · Cited by 39
The Pancreatic β-Cell: The Perfect Redox System
Ježek, P., Holendová, B., Jabůrek, M., Tauber, J. A., Dlasková, A., & Plecitá‐Hlavatá, L. (2021) · Antioxidants · doi:10.3390/antiox10020197 · Cited by 38
Yoder, S. M., Dineen, S. L., Wang, Z.-X., & Thurmond, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559328 · Cited by 40
Stožer, A., Markovič, R., Dolenšek, J., Perc, M., Marhl, M., Rupnik, M. S., & Gosak, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00869 · Cited by 38
Metabolic and Functional Heterogeneity in Pancreatic β Cells
Xavier, G. D. S., & Rutter, G. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.08.005 · Cited by 39
Zhang, T., Wang, S., Li, L., Zhu, A., & Wang, Q. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153932 · Cited by 37
Guiding pancreatic beta cells to target electrodes in a whole-cell biosensor for diabetes
Pedraza, E., Karajić, A., Raoux, M., Perrier, R., Pirog, A., Lebreton, F., Arbault, S., Gaitan, J., Renaud, S., Kuhn, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00616c · Cited by 37
Miranda-Perez, M. E., Ortega‐Camarillo, C., Escobar-Villanueva, M. D. C., Blancas‐Flores, G., & Alarcón-Aguilar, F. J. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.04.061 · Cited by 36
Wu, W., Yao, X., Jiang, L., Zhang, Q., Bai, J., Qiu, T., Yang, L., Gao, N., Yang, G., Liu, X., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.043 · Cited by 36
Circular RNAs in metabolism and metabolic disorders
Zeng, Y.-Z., Zheng, Z., Liu, F., & Yi, G. (2021) · Obesity Reviews · doi:10.1111/obr.13220 · Cited by 40
Updated Understanding of the Crosstalk Between Glucose/Insulin and Cholesterol Metabolism
Xiao, X., Luo, Y., & Peng, D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.879355 · Cited by 66
Calcium signalling and secretory epithelia
Petersen, O. H. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.01.003 · Cited by 36
Pharmacological approach to understanding the control of insulin secretion in human islets
Henquin, J., Dufrane, D., Gmyr, V., Kerr-Conte, J. A., & Nenquin, M. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12887 · Cited by 37
Optimal Glucose Management in the Perioperative Period
Evans, C. H., Lee, J., & Ruhlman, M. K. (2015) · Surgical Clinics of North America · doi:10.1016/j.suc.2014.11.003 · Cited by 37
Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus
Akoumianakis, I., & Antoniades, C. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7421 · Cited by 37
Bahl, V., May, C. L., Perez, A., Gläser, B., & Kaestner, K. H. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101193 · Cited by 34
β-cell secretory dysfunction: a key cause of type 2 diabetes
Holman, R. R., Clark, A., & Rorsman, P. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30119-4 · Cited by 35
Self-citationConnexin 36, a key element in pancreatic beta cell function
Pérez-Armendáriz, E. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.015 · Cited by 34
Metadata
- Authors
- Rorsman, P., & Braun, M.
- Affiliations
- University of Oxford (GB)
- University of Alberta (CA)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2013-02-10
- Volume
- 75
- Issue
- 1
- Pages
- 155-179
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2140402299
- Cited by
- 599
- References
- 134
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 26 · 2023: 44 · 2022: 60 · 2021: 57 · 2020: 42 · 2019: 41 · 2018: 59 · 2017: 47 · 2016: 50 · 2015: 51 · 2014: 54 · 2013: 28
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (095531/Z/11/Z, 095531)
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- insulin secretion, pancreatic beta cells, human beta cells, glucose detection, action potential, ion channels, exocytosis, neurotransmitters, circulating hormones, diabetes mellitus, genetic and environmental risk factors
- MeSH terms
- Insulin Secretion, Action Potentials, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Ion Channels, Islets of Langerhans, Insulin-Secreting Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
