The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Regulation of Insulin Secretion in Human Pancreatic Islets
Abstract
Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β cell is electrically excitable; in response to an elevation of glucose, it depolarizes and starts generating action potentials. The electrophysiology of mouse β cells and the cell's role in insulin secretion have been extensively investigated. More recently, similar studies have been performed on human β cells. These studies have revealed numerous and important differences between human and rodent β cells. Here we discuss the properties of human pancreatic β cells: their glucose sensing, the ion channel complement underlying glucose-induced electrical activity that culminates in exocytotic release of insulin, the cellular control of exocytosis, and the modulation of insulin secretion by circulating hormones and locally released neurotransmitters. Finally, we consider the pathophysiology of insulin secretion and the interactions between genetics and environmental factors that may explain the current diabetes epidemic.
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In the citing paper
“The primary secretory pathway of glucose-stimulated insulin secretion is associated with complex patterns of electrical activity across the plasma membrane, which allow Ca2+ ions to enter the cell and trigger the secretory machinery.”
From Mathematical Modelling of Endocrine Systems (2019) · cites this paper as [11]
In the citing paper
“This electrical activity is coupled to cell metabolism, which acts as a glucose sensor by raising the intracellular ATP:ADP ratio, causing KATP channels to close, depolarising the membrane and driving it towards its threshold for action potential initiation [11].”
From Mathematical Modelling of Endocrine Systems (2019) · cites this paper as [11]
In the citing paper
“Adrenaline and somatostatin lead to transient repolarization and suppression of glucose-induced electrical activity (327, 568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The action potentials of human β-cells are also triggered from a more negative membrane potential in human than in mouse β-cells (-60 mV rather than -50 to -40 mV) and often overshoot, peaking at potentials above zero mV (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The action potentials of both mouse and human β-cells are short, ranging between 5 ms (human) and 30-40 ms (mouse) (568, 570).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Thus, delayed rectifying K+ channels may not activate much during the human β-cell action potential, which lasts only ~5 ms (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Blocking SK channels with apamin, or the non-selective antagonist NS8593, results in membrane depolarization and action potential firing in human β-cells (311) and stimulates insulin secretion (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Inhibition of inward rectifiers with Ba2+ (0.1 mM) or Cs+ (1 mM) in human β-cells exposed to glucose (6 mM) and tolbutamide (0.1 mM) resulted in membrane depolarization and stimulation of action potential firing (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“These currents were blocked by low concentrations of Ba2+ (100 μM) and Cs+ (1 mM).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The Ba2+-sensitive current displayed strongly inward rectification and reversed at ~-85 mV, which is close to EK.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“In human β-cells, hyperpolarizing voltage steps from a holding potential of -70 mV evoked progressively larger tolbutamide-resistant inward currents (553, 568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Similarly, in human β-cells exposed to 6 mM glucose, carbachol evoked membrane depolarization (~5 mV) and increased action potential firing (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The smallest cell aggregates reported by the authors were ca. 200 microns in diameter; the typical human islet has a diameter of ca. 130 microns176.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [176]
Citations
Cites
Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216
Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., & Rajotte, R. V. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430401 · Cited by 5,237
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
The MAGIC investigators, Voight, B. F., The GIANT Consortium, Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.609 · Cited by 1,761
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
Cabrera, O., Berman, D. M., Kenyon, N. S., Ricordi, C., Berggren, P.-O., & Caicedo, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510790103 · Cited by 1,312
Research works printed but not linked: 3
- Hellman B, 1959, Acta Soc. Med. Ups., 64, 432
- Scheen AJ, 1996, Diabetes Metab., 22, 397
- Clark A, 1988, Diabetes Res., 9, 151
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Zamponi, G. W., Striessnig, J., Koschak, A., & DOLPHIN, A. C. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009654 · Cited by 1,158
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
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Ighodaro, O. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.058 · Cited by 585
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Rahman, M. S., Hossain, K. S., Das, S., Kundu, S., Adegoke, E. O., Rahman, M. A., Hannan, M. A., Uddin, M. J., & Pang, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126403 · Cited by 574
Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms
Wu, L., Hamid, E., Shin, W., & Chiang, H. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170305 · Cited by 462
Balboa, D., Barsby, T., Lithovius, V., Saarimäki-Vire, J., Omar-Hmeadi, M., Dyachok, O., Montaser, H., Lund, P.-E., Yang, M., Ibrahim, H., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01219-z · Cited by 433
Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409
Nässel, D. R., & Broeck, J. V. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2063-3 · Cited by 392
Structural similarities and differences between the human and the mouse pancreas
Dolenšek, J., Rupnik, M. S., & Stožer, A. (2015) · Islets · doi:10.1080/19382014.2015.1024405 · Cited by 379
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes
Tang, C., Ahmed, K., Gille, A., Lu, S. Y., Gröne, H., Tunaru, S., & Offermanns, S. (2015) · Nature Medicine · doi:10.1038/nm.3779 · Cited by 340
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes
Camuñas-Soler, J., Dai, X.-Q., Hang, Y., Bautista, A., Lyon, J. G., Suzuki, K., Kim, S. K., Quake, S. R., & MacDonald, P. E. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.005 · Cited by 286
Regulation of Glucose Homeostasis by GLP-1
Nadkarni, P., Chepurny, O. G., & Holz, G. G. (2014) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-800101-1.00002-8 · Cited by 287
KATP channels and islet hormone secretion: new insights and controversies
Ashcroft, F. M., & Rorsman, P. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.166 · Cited by 272
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El‐Merahbi, R., Löffler, M. C., Mayer, A. E., & Sumara, G. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.054 · Cited by 284
Cnop, M., Abdulkarim, B., Bottu, G., Cunha, D. A., Igoillo-Esteve, M., Masini, M., Turatsinze, J.-V., Griebel, T., Villate, O., Santin, I., et al. (2014) · Diabetes · doi:10.2337/db13-1383 · Cited by 250
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Rorsman, P., & Huising, M. O. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0020-6 · Cited by 259
Self-citationUrocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion
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Chen, Z., Wang, J., Sun, W., Ogunnaike, E. A., Kahkoska, A. R., Zhang, X., Lü, Y., Ligler, F. S., Buse, J. B., & Gu, Z. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2511 · Cited by 250
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Chen, Z., Wang, Z., & Gu, Z. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00079 · Cited by 246
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Newsholme, P., Cruzat, V. F., Arfuso, F., & Keane, K. N. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0616 · Cited by 228
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Estadella, D., do Nascimento, C. M. D. P. O., Oyama, L. M., Ribeiro, E. B., Dâmaso, A. R., & de Piano, A. (2013) · Mediators of Inflammation · doi:10.1155/2013/137579 · Cited by 202
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Díaz‐Vegas, A., Sánchez-Aguilera, P., Krycer, J. R., Morales, P. E., Monsalves‐Álvarez, M., Cifuentes, M., Rothermel, B. A., & Lavandero, S. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa005 · Cited by 179
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Cochet-Bissuel, M., Lory, P., & Monteil, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00132 · Cited by 172
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Mirmalek-Sani, S.-H., Orlando, G., McQuilling, J. P., Pareta, R. A., Mack, D. L., Salvatori, M., Farney, A. C., Stratta, R. J., Atala, A., Opara, E. C., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.054 · Cited by 170
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Goginashvili, A., Zhang, Z., Erbs, E., Spiegelhalter, C., Kessler, P., Mihlan, M., Pasquier, A., Krupina, K., Schieber, N., Cinque, L., et al. (2015) · Science · doi:10.1126/science.aaa2628 · Cited by 160
Bouret, S., Levin, B. E., & Ozanne, S. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00007.2014 · Cited by 157
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Perego, C., Dalt, L. D., Pirillo, A., Galli, A., Catapano, A. L., & Norata, G. D. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.012 · Cited by 143
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Yin, R., Kyle, J. E., Burnum-Johnson, K., Bloodsworth, K., Sussel, L., Ansong, C. K., & Laskin, J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b00161 · Cited by 101
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Kim, Y., Kim, H., Ko, U. H., Oh, Y., Lim, A., Sohn, J., Shin, J. H., Kim, H., & Han, Y. (2016) · Scientific Reports · doi:10.1038/srep35145 · Cited by 101
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Rorsman, P., Ramracheya, R. D., Rorsman, N. J. G., & Zhang, Q. (2014) · Diabetologia · doi:10.1007/s00125-014-3279-8 · Cited by 93
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“This electrical activity is coupled to cell metabolism, which acts as a glucose sensor by raising the intracellular ATP:ADP ratio, causing KATP channels to close, depolarising the membrane and driving it towards its threshold for action potential initiation [11].”
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Metadata
- Authors
- Rorsman, P., & Braun, M.
- Affiliations
- University of Oxford (GB)
- University of Alberta (CA)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2013-02-10
- Volume
- 75
- Issue
- 1
- Pages
- 155-179
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2140402299
- Cited by
- 599
- References
- 134
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 26 · 2023: 44 · 2022: 60 · 2021: 57 · 2020: 42 · 2019: 41 · 2018: 59 · 2017: 47 · 2016: 50 · 2015: 51 · 2014: 54 · 2013: 28
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (095531/Z/11/Z, 095531)
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- insulin secretion, pancreatic beta cells, human beta cells, glucose detection, action potential, ion channels, exocytosis, neurotransmitters, circulating hormones, diabetes mellitus, genetic and environmental risk factors
- MeSH terms
- Insulin Secretion, Action Potentials, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Ion Channels, Islets of Langerhans, Insulin-Secreting Cells
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