The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Regulation of Insulin Secretion in Human Pancreatic Islets
Abstract
Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β cell is electrically excitable; in response to an elevation of glucose, it depolarizes and starts generating action potentials. The electrophysiology of mouse β cells and the cell's role in insulin secretion have been extensively investigated. More recently, similar studies have been performed on human β cells. These studies have revealed numerous and important differences between human and rodent β cells. Here we discuss the properties of human pancreatic β cells: their glucose sensing, the ion channel complement underlying glucose-induced electrical activity that culminates in exocytotic release of insulin, the cellular control of exocytosis, and the modulation of insulin secretion by circulating hormones and locally released neurotransmitters. Finally, we consider the pathophysiology of insulin secretion and the interactions between genetics and environmental factors that may explain the current diabetes epidemic.
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In the citing paper
“The primary secretory pathway of glucose-stimulated insulin secretion is associated with complex patterns of electrical activity across the plasma membrane, which allow Ca2+ ions to enter the cell and trigger the secretory machinery.”
From Mathematical Modelling of Endocrine Systems (2019) · cites this paper as [11]
In the citing paper
“This electrical activity is coupled to cell metabolism, which acts as a glucose sensor by raising the intracellular ATP:ADP ratio, causing KATP channels to close, depolarising the membrane and driving it towards its threshold for action potential initiation [11].”
From Mathematical Modelling of Endocrine Systems (2019) · cites this paper as [11]
In the citing paper
“Adrenaline and somatostatin lead to transient repolarization and suppression of glucose-induced electrical activity (327, 568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The action potentials of human β-cells are also triggered from a more negative membrane potential in human than in mouse β-cells (-60 mV rather than -50 to -40 mV) and often overshoot, peaking at potentials above zero mV (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The action potentials of both mouse and human β-cells are short, ranging between 5 ms (human) and 30-40 ms (mouse) (568, 570).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Thus, delayed rectifying K+ channels may not activate much during the human β-cell action potential, which lasts only ~5 ms (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Blocking SK channels with apamin, or the non-selective antagonist NS8593, results in membrane depolarization and action potential firing in human β-cells (311) and stimulates insulin secretion (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Inhibition of inward rectifiers with Ba2+ (0.1 mM) or Cs+ (1 mM) in human β-cells exposed to glucose (6 mM) and tolbutamide (0.1 mM) resulted in membrane depolarization and stimulation of action potential firing (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“These currents were blocked by low concentrations of Ba2+ (100 μM) and Cs+ (1 mM).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The Ba2+-sensitive current displayed strongly inward rectification and reversed at ~-85 mV, which is close to EK.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“In human β-cells, hyperpolarizing voltage steps from a holding potential of -70 mV evoked progressively larger tolbutamide-resistant inward currents (553, 568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“Similarly, in human β-cells exposed to 6 mM glucose, carbachol evoked membrane depolarization (~5 mV) and increased action potential firing (568).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [568]
In the citing paper
“The smallest cell aggregates reported by the authors were ca. 200 microns in diameter; the typical human islet has a diameter of ca. 130 microns176.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [176]
Citations
Cites
Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216
Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., & Rajotte, R. V. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430401 · Cited by 5,237
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
The MAGIC investigators, Voight, B. F., The GIANT Consortium, Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.609 · Cited by 1,761
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
Cabrera, O., Berman, D. M., Kenyon, N. S., Ricordi, C., Berggren, P.-O., & Caicedo, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510790103 · Cited by 1,312
Triggering and amplifying pathways of regulation of insulin secretion by glucose.
Henquin, J. C. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1751 · Cited by 1,201
Genomics, type 2 diabetes, and obesity
McCarthy, M. I. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0906948 · Cited by 938
Type 2 diabetes across generations: from pathophysiology to prevention and management
Nolan, C. J., Damm, P., & Prentki, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60614-4 · Cited by 923
Diabetes Mellitus and the β Cell: The Last Ten Years
Ashcroft, F. M., & Rorsman, P. (2012) · Cell · doi:10.1016/j.cell.2012.02.010 · Cited by 902
Self-citationObesity, insulin resistance and free fatty acids
Boden, G. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3283444b09 · Cited by 848
Insulin granule dynamics in pancreatic beta cells
Rorsman, P., & Renstr�m, E. (2003) · Diabetologia · doi:10.1007/s00125-003-1153-1 · Cited by 844
Self-citationVariants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H., Hirota, Y., Mori, H., Jonsson, A., Sato, Y., et al. (2008) · Nature Genetics · doi:10.1038/ng.207 · Cited by 776
Unoki, H., Takahashi, A., Kawaguchi, T., Hara, K., Horikoshi, M., Andersen, G., Ng, D. P. K., Holmkvist, J., Borch-Johnsen, K., Jørgensen, T., et al. (2008) · Nature Genetics · doi:10.1038/ng.208 · Cited by 725
Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
Unger, R. H., & Cherrington, A. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60016 · Cited by 670
Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic -Cell Function
Gilon, P., & Henquin, J. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.5.0440 · Cited by 521
Clark, A., Wells, C. A., BULEY, I. D., Cruickshank, J. K., Vanhegan, R. I., Matthews, D. R., Cooper, G. J. S., Holman, R. R., & Turner, R. C. (1988) · PubMed · Cited by 518
Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
Maechler, P., & Wollheim, C. B. (1999) · Nature · doi:10.1038/45280 · Cited by 507
Kashyap, S., Belfort, R., Gastaldelli, A., Pratipanawatr, T., Berria, R., Pratipanawatr, W., Bajaj, M., Mandarino, L., DeFronzo, R., & Cusi, K. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2461 · Cited by 503
Functional and Molecular Defects of Pancreatic Islets in Human Type 2 Diabetes
Del Guerra, S., Lupi, R., Marselli, L., Masini, M., Bugliani, M., Sbrana, S., Torri, S., Pollera, M., Boggi, U., Mosca, F., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.3.727 · Cited by 466
Unique Arrangement of α- and β-Cells in Human Islets of Langerhans
Bosco, D., Armanet, M., Morel, P., Niclauss, N., Sgroi, A., Muller, Y. D., Giovannoni, L., Parnaud, G., & Berney, T. (2010) · Diabetes · doi:10.2337/db09-1177 · Cited by 450
Mechanism of glucose-induced insulin secretion.
Hedeskov, C. J. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.2.442 · Cited by 435
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
De Vos, A., Heimberg, H., Quartier, E., Huypens, P., Bouwens, L., Pipeleers, D., & Schuit, F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118308 · Cited by 425
Metabolic Fate of Glucose in Purified Islet Cells
Schuit, F., De Vos, A., Farfari, S., Moens, K., Pipeleers, D., Brun, T., & Prentki, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18572 · Cited by 421
Braun, M., Ramracheya, R., Bengtsson, M., Zhang, Q., Karanauskaite, J., Partridge, C., Johnson, P. R., & Rorsman, P. (2008) · Diabetes · doi:10.2337/db07-0991 · Cited by 417
Self-citationCyclic Oscillations of Basal Plasma Glucose and Insulin Concentrations in Human Beings
Lang, D. A., Matthews, D. R., Peto, J., & Turner, R. C. (1979) · New England Journal of Medicine · doi:10.1056/nejm197911083011903 · Cited by 400
Sako, Y., & Grill, V. (1990) · Endocrinology · doi:10.1210/endo-127-4-1580 · Cited by 370
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
Seino, S., Shibasaki, T., & Minami, K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45680 · Cited by 364
Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas
Rodriguez-Diaz, R., Abdulreda, M. H., Formoso, A. L., Gans, I., Ricordi, C., Berggren, P.-O., & Caicedo, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.008 · Cited by 356
Stein, D. T., Stevenson, B. E., Chester, M. W., Basit, M., Daniels, M. B., Turley, S. D., & McGarry, J. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119546 · Cited by 352
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
Kotarsky, K., Nilsson, N. E., Flodgren, E., Owman, C., & Olde, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)03064-4 · Cited by 352
Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects
Deng, S., Vatamaniuk, M. Z., Huang, X., Doliba, N. M., Lian, M.-M., Frank, A. M., Velidedeoğlu, E., Desai, N. M., Koeberlein, B., Wolf, B. A., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.3.624 · Cited by 346
Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
Lee, Y., Wang, M.-Y., Du, X. Q., Charron, M. J., & Unger, R. H. (2011) · Diabetes · doi:10.2337/db10-0426 · Cited by 327
Rodriguez‐Diaz, R., Dando, R., Jacques-Silva, M. C., Fachado, A., Molina, J., Abdulreda, M. H., Ricordi, C., Roper, S. D., Berggren, P., & Caicedo, A. (2011) · Nature Medicine · doi:10.1038/nm.2371 · Cited by 305
Metabolic Regulation: A Human Perspective
Frayn, K. N. (1996) · Cited by 273
Ivarsson, R., Quintens, R., Dejonghe, S., Tsukamoto, K., in ’t Veld, P., Renström, E., & Schuit, F. C. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2132 · Cited by 265
SUR1 Regulates PKA-independent cAMP-induced Granule Priming in Mouse Pancreatic B-cells
Eliasson, L., Ma, X., Renström, E., Barg, S., Berggren, P.-O., Galvanovskis, J., Gromada, J., Jing, X., Lundquist, I., Salehi, A., et al. (2003) · The Journal of General Physiology · doi:10.1085/jgp.20028707 · Cited by 257
Self-citationγ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells
Braun, M., Ramracheya, R., Bengtsson, M., Clark, A., Walker, J. N., Johnson, P. R., & Rorsman, P. (2010) · Diabetes · doi:10.2337/db09-0797 · Cited by 239
Self-citationOkada, Y., Taniguchi, H., & Shimada, C. (1976) · Science · doi:10.1126/science.185693 · Cited by 238
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes
Rosengren, A. H., Braun, M., Mahdi, T., Andersson, S. A., Travers, M. E., Shigeto, M., Zhang, E., Almgren, P., Ladenvall, C., Axelsson, A. S., et al. (2012) · Diabetes · doi:10.2337/db11-1516 · Cited by 237
Self-citationOstenson, C.-G., Gaisano, H., Sheu, L., Tibell, A., & Bartfai, T. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db04-1575 · Cited by 232
Nutrient Control of Insulin Secretion in Isolated Normal Human Islets
Henquin, J.-C., Dufrane, D., & Nenquin, M. (2006) · Diabetes · doi:10.2337/db06-0868 · Cited by 228
Voltage‐gated and resting membrane currents recorded from B‐cells in intact mouse pancreatic islets
Göpel, S., Kanno, T., Barg, S., Galvanovskis, J., & Rorsman, P. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00717.x · Cited by 226
Self-citationAbstracts of the IDF Congress in Paris 2003
(2003) · Diabetologia · doi:10.1007/s00125-003-1190-9 · Cited by 211
McCulloch, L. J., van de Bunt, M., Braun, M., Frayn, K. N., Clark, A., & Gloyn, A. L. (2011) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2011.08.026 · Cited by 207
Self-citationPKC-Dependent Stimulation of Exocytosis by Sulfonylureas in Pancreatic β Cells
Eliasson, L., Renström, E., Ämmälä, C., Berggren, P., Bertorello, A. M., Bokvist, K. B., Chibalin, A., Deeney, J. T., Flatt, P. R., Gäbel, J., et al. (1996) · Science · doi:10.1126/science.271.5250.813 · Cited by 193
Self-citationElectrophysiology of Stimulus-Secretion Coupling in Human β-Cells
Misler, S., Barnett, D. W., Gillis, K. D., & Pressel, D. M. (1992) · Diabetes · doi:10.2337/diab.41.10.1221 · Cited by 191
Gromada, J., Bokvist, K. B., Ding, W., Holst, J. J., Nielsen, J. H., & Rorsman, P. (1998) · Diabetes · doi:10.2337/diab.47.1.57 · Cited by 189
Self-citationRenström, E., Ding, W.-G., Bokvist, K., & Rorsman, P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80183-x · Cited by 186
Self-citationKv2.1 Ablation Alters Glucose-Induced Islet Electrical Activity, Enhancing Insulin Secretion
Jacobson, D. A., Kuznetsov, A., Lopez, J. P., Kash, S., Ämmälä, C. E., & Philipson, L. H. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.07.010 · Cited by 180
Smith, P. A., Ashcroft, F. M., & Rorsman, P. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80667-8 · Cited by 169
Self-citationSSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
Kailey, B., van de Bunt, M., Cheley, S., Johnson, P. R., MacDonald, P. E., Gloyn, A. L., Rorsman, P., & Braun, M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00207.2012 · Cited by 164
Self-citationGöpel, S., Zhang, Q., Eliasson, L., Ma, X., Galvanovskis, J., Kanno, T., Salehi, A., & Rorsman, P. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.059675 · Cited by 160
Self-citationMechanisms and Physiological Significance of the Cholinergic Control of Pancreatic -Cell Function
Gilon, P. (2001) · Endocrine Reviews · doi:10.1210/er.22.5.565 · Cited by 154
The emerging genetics of type 2 diabetes
Bonnefond, A., Froguel, P., & Vaxillaire, M. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.06.004 · Cited by 153
Hoppa, M. B., Collins, S., Ramracheya, R., Hodson, L., Amisten, S., Zhang, Q., Johnson, P., Ashcroft, F. M., & Rorsman, P. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.011 · Cited by 152
Self-citationElectrogenic arginine transport mediates stimulus‐secretion coupling in mouse pancreatic beta‐cells.
Smith, P. A., Sakura, H., Coles, B., Gummerson, N., Proks, P., & Ashcroft, F. M. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021955 · Cited by 142
Selective nucleotide-release from dense-core granules in insulin-secreting cells
Obermüller, S., Lindqvist, A., Karanauskaite, J., Galvanovskis, J., Rorsman, P., & Barg, S. (2005) · Journal of Cell Science · doi:10.1242/jcs.02549 · Cited by 138
Self-citationGöpel, S. O., Kanno, T., Barg, S., Eliasson, L., Galvanovskis, J., Renström, E., & Rorsman, P. (1999) · The Journal of General Physiology · doi:10.1085/jgp.114.6.759 · Cited by 137
Self-citationRamracheya, R., Ward, C., Shigeto, M., Walker, J. N., Amisten, S., Zhang, Q., Johnson, P. R., Rorsman, P., & Braun, M. (2010) · Diabetes · doi:10.2337/db09-1505 · Cited by 136
Self-citationRorsman, P., Bokvist, K., Ämmälä, C., Arkhammar, P., Berggren, P.-O., Larsson, O., & Wåhlander, K. (1991) · Nature · doi:10.1038/349077a0 · Cited by 135
Self-citationRosati, B., Marchetti, P., Crociani, O., Lecchi, M., Lupi, R., Arcangeli, A., Olivotto, M., & Wanke, E. (2000) · The FASEB Journal · doi:10.1096/fj.00-0077com · Cited by 133
Somatostatin Receptor Subtype 5 Regulates Insulin Secretion and Glucose Homeostasis
Strowski, M. Z., Köhler, M. G., Chen, H. Y., Trumbauer, M. E., Li, Z., Szalkowski, D., Gopal-Truter, S., Fisher, J. K., Schaeffer, J. M., Blake, A. D., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2001-0035 · Cited by 130
Jacques-Silva, M. C., Correa-Medina, M., Cabrera, O., Rodriguez-Diaz, R., Makeeva, N., Fachado, A., Diez, J., Berman, D. M., Kenyon, N. S., Ricordi, C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908935107 · Cited by 127
Hosker, J. P., Rudenski, A. S., Burnett, M. A., Matthews, D. R., & Turner, R. C. (1989) · Metabolism · doi:10.1016/0026-0495(89)90064-4 · Cited by 125
Singh, V., Brendel, M. D., Zacharias, S., Mergler, S., Jahr, H., Wiedenmann, B., Bretzel, R. G., Plöckinger, U., & Strowski, M. Z. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1578 · Cited by 123
Jeans, A. F., Oliver, P. L., Johnson, R., Capogna, M., Vikman, J., Molnár, Z., Babbs, A., Partridge, C. J., Salehi, A. A., Bengtsson, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610222104 · Cited by 122
Self-citationClustering of metabolic comorbidity in schizophrenia: a genetic contribution?
Gough, S. C. L., & O’Donovan, M. C. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105058380 · Cited by 121
The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β‐cell line
Swayne, L. A., Mezghrani, A., Varrault, A., Chemin, J., Bertrand, G., Dalle, S., Bourinet, E., Lory, P., Miller, R. J., Nargeot, J., et al. (2009) · EMBO Reports · doi:10.1038/embor.2009.125 · Cited by 121
γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
Taneera, J., Jin, Z., Jin, Y., Muhammed, S. J., Zhang, E., Lang, S., Salehi, A., Korsgren, O., Renström, E., Groop, L., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2548-7 · Cited by 117
R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion
Zhang, Q., Bengtsson, M., Partridge, C., Salehi, A., Braun, M., Cox, R., Eliasson, L., Johnson, P. R., Renström, E., Schneider, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1563 · Cited by 110
Self-citationGloyn, A. L., Odili, S., Zelent, D., Buettger, C., Castleden, H. A. J., Steele, A. M., Stride, A., Shiota, C., Magnuson, M. A., Lorini, R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413146200 · Cited by 108
Differences between Human and Rodent Pancreatic Islets
MacDonald, M. J., Longacre, M. J., Stoker, S. W., Kendrick, M. A., Thonpho, A., Brown, L. J., Hasan, N. M., Jitrapakdee, S., Fukao, T., Hanson, M. S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.241182 · Cited by 105
Quesada, I., Todorova, M. G., Alonso-Magdalena, P., Beltrá, M., Carneiro, E. M., Martin, F., Nadal, A., & Soria, B. (2006) · Diabetes · doi:10.2337/db06-0272 · Cited by 104
Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans
Rorsman, P., Eliasson, L., Kanno, T., Zhang, Q., & Gopel, S. (2011) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2011.06.009 · Cited by 103
Self-citationAutocrine regulation of insulin secretion
Braun, M., Ramracheya, R. D., & Rorsman, P. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01642.x · Cited by 103
Self-citationGlucose-induced changes in pancreatic islet blood flow mediated by central nervous system.
Jansson, L., & Hellerström, C. (1986) · American Journal of Physiology · doi:10.1152/ajpendo.1986.251.6.e644 · Cited by 103
KATP-channels and glucose-regulated glucagon secretion
Rorsman, P., Salehi, A. A., Abdulkader, F., Braun, M., & MacDonald, P. E. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.07.003 · Cited by 102
Self-citationType 2 diabetes mellitus: not quite exciting enough?
Ashcroft, F. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh066 · Cited by 102
IN VIVO EFFECT OF FK506 ON HUMAN PANCREATIC ISLETS
RICORDI, C., ZENG, Y., ALEJANDRO, R., TZAKIS, A., VENKATARAMANAN, R., FUNG, J., BEREITER, D., MINTZ, D. H., & STARZL, T. E. (1991) · Transplantation · doi:10.1097/00007890-199109000-00026 · Cited by 102
Synaptotagmin‐7 is a principal Ca2+ sensor for Ca2+‐induced glucagon exocytosis in pancreas
Gustavsson, N., Wei, S., Hoang, D. N., Lao, Y., Zhang, Q., Radda, G. K., Rorsman, P., Südhof, T. C., & Han, W. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.168005 · Cited by 100
Self-citationBarnett, D. W., Pressel, D. M., & Misler, S. (1995) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00410201 · Cited by 100
Adipose tissue fatty acid metabolism in insulin-resistant men
Bickerton, A. S. T., Roberts, R., Fielding, B. A., Tornqvist, H. E., Blaak, E. E., Wagenmakers, A. J. M., Gilbert, M., Humphreys, S. M., Karpe, F., & Frayn, K. N. (2008) · Diabetologia · doi:10.1007/s00125-008-1040-x · Cited by 99
Braun, M., Ramracheya, R. D., Amisten, S., Bengtsson, M., Moritoh, Y., Zhang, Q., Johnson, P., & Rorsman, P. (2009) · Diabetologia · doi:10.1007/s00125-009-1382-z · Cited by 98
Self-citationDoliba, N. M., Qin, W., Najafi, H., Liu, C., Buettger, C. W., Sotiris, J., Collins, H. W., Li, C., Stanley, C. A., Wilson, D. F., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00218.2011 · Cited by 96
Olofsson, C. S., Salehi, A. A., Göpel, S., Holm, C., & Rorsman, P. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2836 · Cited by 93
Self-citationDai, X.-Q., Plummer, G., Casimir, M., Kang, Y., Hajmrle, C., Gaisano, H. Y., Manning Fox, J. E., & MacDonald, P. E. (2011) · Diabetes · doi:10.2337/db10-0440 · Cited by 92
Ryanodine receptors in human pancreatic β cells: localization and effects on insulin secretion
Johnson, J. D., Kuang, S., Misler, S., & Polonsky, K. S. (2004) · The FASEB Journal · doi:10.1096/fj.03-1280fje · Cited by 91
Kanno, T., Rorsman, P., & Göpel, S. O. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.031344 · Cited by 89
Self-citationScheen, A. J., Castillo, M. J., & Lefèbvre, P. J. (1996) · PubMed · Cited by 87
Varadi, A., Tsuboi, T., Johnson-Cadwell, L. I., Allan, V. J., & Rutter, G. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.208 · Cited by 86
Na+ currents in cultured mouse pancreatic B-cells
Plant, T. D. (1988) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00587723 · Cited by 85
Yashiro, H., Tsujihata, Y., Takeuchi, K., Hazama, M., Johnson, P. R. V., & Rorsman, P. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.187708 · Cited by 84
Self-citationGray, E. H., Muller, D. S., Squires, P. E., Asare‐Anane, H., Huang, G.-C., Amiel, S. A., Persaud, S. J., & Jones, P. M. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06891 · Cited by 81
Chepurny, O., Kelley, G., Dzhura, I., Leech, C. A., Roe, M., Dzhura, E., Li, X., Schwede, F., Genieser, H., & Holz, G. G. (2010) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00630.2009 · Cited by 80
Hellman, B. (1959) · Nature · doi:10.1038/1841498a0 · Cited by 74
Role of the Vesicular Chloride Transporter ClC-3 in Neuroendocrine Tissue
Maritzen, T., Keating, D. J., Neagoe, I., Zdebik, A. A., & Jentsch, T. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3750-08.2008 · Cited by 74
Jacobson, D. A., Mendez, F., Thompson, M., Torres, J., Cochet, O., & Philipson, L. H. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190207 · Cited by 73
Control of the Intracellular Redox State by Glucose Participates in the Insulin Secretion Mechanism
Rebelato, E., Abdulkader, F., Curi, R., & Carpinelli, Â. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024507 · Cited by 73
Casting a wider net for diabetes susceptibility genes
McCarthy, M. I. (2008) · Nature Genetics · doi:10.1038/ng0908-1039 · Cited by 72
Human Insulin Vesicle Dynamics During Pulsatile Secretion
Michael, D. J., Xiong, W., Geng, X., Drain, P., & Chow, R. H. (2007) · Diabetes · doi:10.2337/db06-0367 · Cited by 69
Transient Receptor Potential Cation Channels in Pancreatic β Cells
Colsoul, B., Vennekens, R., & Nilius, B. (2011) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2011_2 · Cited by 67
Targeting GIRK Channels for the Development of New Therapeutic Agents
Walsh, K. B. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00064 · Cited by 67
P2 Receptor Agonists Stimulate Insulin Release from Human Pancreatic Islets
Fernandez-Alvarez, J., Hillaire-Buys, D., Loubati??res-Mariani, M.-M., Gomis, R., & Petit, P. (2001) · Pancreas · doi:10.1097/00006676-200101000-00012 · Cited by 66
Metabolite-Regulated ATP-Sensitive K+ Channel in Human Pancreatic Islet Cells
Misler, S., Gee, W. M., Gillis, K. D., Scharp, D. W., & Falke, L. C. (1989) · Diabetes · doi:10.2337/diab.38.4.422 · Cited by 66
Calcium-activated K+ Channels of Mouse β-cells are Controlled by Both Store and Cytoplasmic Ca2+
Goforth, P. B., Bertram, R., Khan, F. A., Zhang, M., Sherman, A., & Satin, L. S. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028581 · Cited by 65
Exocytotic Properties of Human Pancreatic β‐cells
Braun, M., Ramracheya, R., Johnson, P. R., & Rorsman, P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03992.x · Cited by 60
Self-citationKiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells
Hanna, S. T., Pigeau, G. M., Galvanovskis, J., Clark, A., Rorsman, P., & MacDonald, P. E. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0588-0 · Cited by 57
Self-citationEnhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells
Düfer, M., Gier, B., Wolpers, D., Krippeit-Drews, P., Ruth, P., & Drews, G. (2009) · Diabetes · doi:10.2337/db08-1324 · Cited by 56
Diverse roles of extracellular calcium‐sensing receptor in the central nervous system
Bandyopadhyay, S., Tfelt‐Hansen, J., & Chattopadhyay, N. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22391 · Cited by 52
Protein metabolic effects of a prolonged fast and hypocaloric refeeding
Hoffer, L. J., & Forse, R. A. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.5.e832 · Cited by 52
Li, D.-Q., Jing, X., Salehi, A., Collins, S. C., Hoppa, M. B., Rosengren, A. H., Zhang, E., Lundquist, I., Olofsson, C. S., Mörgelin, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.011 · Cited by 50
Self-citationGating modifier peptides as probes of pancreatic β-cell physiology
Herrington, J. (2007) · Toxicon · doi:10.1016/j.toxicon.2006.09.012 · Cited by 50
Holmkvist, J., Tojjar, D., Almgren, P.-E., Lyssenko, V., Lindgren, C. M., Isomaa, B., Tuomilehto, J., Berglund, G., Renström, E., & Groop, P. (2007) · Diabetologia · doi:10.1007/s00125-007-0846-2 · Cited by 49
Dai, X.-Q., Fox, J. E. M., Chikvashvili, D., Casimir, M., Plummer, G., Hajmrle, C., Spigelman, A., Kin, T., Singer-Lahat, D., Kang, Y., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2512-6 · Cited by 46
New Uses for Old Drugs: Neonatal Diabetes and Sulphonylureas
Ashcroft, F. M. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.004 · Cited by 45
Voltage‐activated calcium and potassium currents in human pancreatic beta‐cells.
Kelly, R. P., Sutton, R., & Ashcroft, F. M. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018829 · Cited by 45
SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses.
Johnson, R., Oliver, P. L., & Davies, K. E. (2008) · Acta Biochimica Polonica · doi:10.18388/abp.2008_3022 · Cited by 45
Tirone, T. A., Norman, M. A., Moldovan, S., DeMayo, F. J., Wang, X. P., & Brunicardi, F. C. (2003) · Pancreas · doi:10.1097/00006676-200304000-00025 · Cited by 41
Palmitate-induced Ca2+-signaling in pancreatic beta-cells
Remizov, O., Jakubov, R., Düfer, M., Krippeit Drews, P., Drews, G., Waring, M., Brabant, G., Wienbergen, A., Rustenbeck, I., & Schöfl, C. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.09.026 · Cited by 41
Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of KATP-Induced Diabetes
Remedi, M. S., Agapova, S. E., Vyas, A. K., Hruz, P. W., & Nichols, C. G. (2011) · Diabetes · doi:10.2337/db11-0538 · Cited by 36
Silva, A. M., Rodrigues, R. J., Tomé, Â. R., Cunha, R. A., Misler, S., Rosário, L. M., & Santos, R. M. (2008) · Pancreas · doi:10.1097/mpa.0b013e31815a8473 · Cited by 35
Stefanovski, D., Richey, J. M., Woolcott, O. O., Lottati, M., Zheng, D., Harrison, L. N., Ionut, V., Kim, S. P., Hsu, I. R., & Bergman, R. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018134 · Cited by 34
Gromada, J., Bokvist, K. B., Ding, W. G., Holst, J. J., Nielsen, J. H., & Rorsman, P. (1998) · Diabetes · doi:10.2337/diabetes.47.1.57 · Cited by 34
Self-citationHellman, B. (1959) · PubMed · Cited by 30
Brunicardi, F. C., Atiya, A., Moldovan, S., Lee, T. C., Fagan, S. P., Kleinman, R. M., Adrian, T. E., Coy, D. H., Walsh, J. H., & Fisher, W. E. (2003) · Pancreas · doi:10.1097/00006676-200311000-00019 · Cited by 23
Electrophysiology of stimulus-secretion coupling in human beta-cells
Misler, S., Barnett, D. W., Gillis, K. D., & Pressel, D. M. (1992) · Diabetes · doi:10.2337/diabetes.41.10.1221 · Cited by 23
Comparison of cellular and medium insulin and GABA content as markers for living β-cells
Wang, C., Ling, Z., & PIPELEERS, D. G. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00222.2004 · Cited by 21
Galvanovskis, J., Braun, M., & Rorsman, P. (2011) · Interface Focus · doi:10.1098/rsfs.2010.0006 · Cited by 17
Self-citationIncreased levels of free fatty acids in fasted mice stimulate in vivo beta-cell electrical activity.
Fernández, J., & Valdeolmillos, M. (1998) · Diabetes · doi:10.2337/diabetes.47.11.1707 · Cited by 14
Metabolite-regulated ATP-sensitive K+ channel in human pancreatic islet cells
Misler, S., Gee, W. M., Gillis, K. D., et al. (1989) · Diabetes · doi:10.2337/diabetes.38.4.422 · Cited by 12
The αβδ of ion channels in human islet cells
Braun, M. (2009) · Islets · doi:10.4161/isl.1.2.9405 · Cited by 9
Self-citation
Research works printed but not linked: 3
- Hellman B, 1959, Acta Soc. Med. Ups., 64, 432
- Scheen AJ, 1996, Diabetes Metab., 22, 397
- Clark A, 1988, Diabetes Res., 9, 151
Cited by
Sorted by citations
Zamponi, G. W., Striessnig, J., Koschak, A., & DOLPHIN, A. C. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009654 · Cited by 1,158
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
Self-citationMolecular pathways associated with oxidative stress in diabetes mellitus
Ighodaro, O. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.058 · Cited by 585
Role of Insulin in Health and Disease: An Update
Rahman, M. S., Hossain, K. S., Das, S., Kundu, S., Adegoke, E. O., Rahman, M. A., Hannan, M. A., Uddin, M. J., & Pang, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126403 · Cited by 574
Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms
Wu, L., Hamid, E., Shin, W., & Chiang, H. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170305 · Cited by 462
Metadata
- Authors
- Rorsman, P., & Braun, M.
- Affiliations
- University of Oxford (GB)
- University of Alberta (CA)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2013-02-10
- Volume
- 75
- Issue
- 1
- Pages
- 155-179
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2140402299
- Cited by
- 599
- References
- 134
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 26 · 2023: 44 · 2022: 60 · 2021: 57 · 2020: 42 · 2019: 41 · 2018: 59 · 2017: 47 · 2016: 50 · 2015: 51 · 2014: 54 · 2013: 28
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (095531/Z/11/Z, 095531)
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- insulin secretion, pancreatic beta cells, human beta cells, glucose detection, action potential, ion channels, exocytosis, neurotransmitters, circulating hormones, diabetes mellitus, genetic and environmental risk factors
- MeSH terms
- Insulin Secretion, Action Potentials, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Ion Channels, Islets of Langerhans, Insulin-Secreting Cells
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