The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Sepsis-Induced Immunosuppression
Open accessAbstract
Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising number of diseases, and immune-suppressing therapies in organ transplant recipients and cancer patients. It is now recognized that sepsis is associated with profound and sustained immunosuppression, which has been implicated as a predisposing factor in the increased susceptibility of patients to secondary infections and mortality. In this review, we discuss mechanisms of sepsis-induced immunosuppression and biomarkers that identify a state of impaired immunity. We also highlight immune-enhancing strategies that have been evaluated in patients with sepsis, as well as therapeutics under current investigation. Finally, we describe future challenges and the need for a new treatment paradigm, integrating predictive enrichment with patient factors that may guide the future selection of tailored immunotherapy.
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Cites
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α
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Cited by
GPX4, ferroptosis, and diseases
Zhang, W., Liu, Y., Liao, Y., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 426
Immunopathophysiology of human sepsis
Wiersinga, W. J., & van der Poll, T. (2022) · eBioMedicine · doi:10.1016/j.ebiom.2022.104363 · Cited by 322
Self-citation
Metadata
- Authors
- Torres, L. K., Pickkers, P., & van der Poll, T.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2022-02-10
- Volume
- 84
- Issue
- 1
- Pages
- 157-181
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W3210828635
- Cited by
- 355
- References
- 138
- FWCI
- 10.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Torres, L. K., Pickkers, P., & van der Poll, T. (2022). Sepsis-Induced Immunosuppression. Annual Review of Physiology. https://doi.org/10.1146/annurev-physiol-061121-040214
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
