Cited by 111Glaucoma and retinal disordersNeuroprotection in Cerebral IschemiaNerve injury and regeneration

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Neuroprotection in Glaucoma: Animal Models and Clinical Trials

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Almasieh, Mohammadali, Levin, Leonard A.·2017·Annual Review of Vision Science

DOI 10.1146/annurev-vision-102016-061422

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Abstract

Glaucoma is a progressive neurodegenerative disease that frequently results in irreversible blindness. Glaucoma causes death of retinal ganglion cells (RGCs) and their axons in the optic nerve, resulting in visual field deficits and eventual loss of visual acuity. Glaucoma is a complex optic neuropathy, and a successful strategy for its treatment requires not only better management of known risk factors such as elevated intraocular pressure and the development of improved tools for detecting RGC injury but also treatments that address this injury (i.e., neuroprotection). Experimental models of glaucoma provide insight into the cellular and molecular mechanisms of glaucomatous optic neuropathy and aid the development of neuroprotective therapies.

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Calibration of the TonoLab Tonometer in Mice with Spontaneous or Experimental Glaucoma
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Optic Nerve Disease and Axon Pathophysiology
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A medical device/drug delivery system for treatment of glaucoma
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Increased Mitochondrial Fission and Volume Density by Blocking Glutamate Excitotoxicity Protect Glaucomatous Optic Nerve Head Astrocytes
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Accuracy of Pupil Assessment for the Detection of Glaucoma
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Dendritic and Synaptic Protection: Is It Enough to Save the Retinal Ganglion Cell Body and Axon?
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Lost in Translation
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Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB
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A Comparison of Argon Laser and Diode Laser Photocoagulation of the Trabecular Meshwork to Produce the Glaucoma Monkey Model
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Autoimmune aspects in glaucoma
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In Vivo Imaging of Retinal Ganglion Cell Axons within the Nerve Fiber Layer
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A topical nitric oxide-releasing dexamethasone derivative: effects on intraocular pressure and ocular haemodynamics in a rabbit glaucoma model
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Identification and localization of lamina cribrosa cells in the human optic nerve head
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Neuroprotection and regeneration in glaucoma.
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Autoimmune biomarkers in glaucoma patients
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Effect of the Aβ Aggregation Modulator MRZ-99030 on Retinal Damage in an Animal Model of Glaucoma
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Animal and Culture Models of Glaucoma for Studying Neuroprotection
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Central Visual Pathways in Glaucoma
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Glaucoma-Induced Degeneration of Retinal Ganglion Cells Prevented by Hypoxic Preconditioning: A Model of Glaucoma Tolerance
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Controlled Release of Dexamethasone From an Intravitreal Delivery System Using Porous Silicon Dioxide
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Effect of Restricting Perimetry Testing Algorithms to Reliable Sensitivities on Test-Retest Variability
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Identifying specific RGC types may shed light on their idiosyncratic responses to neuroprotection
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Targeting retinal ganglion cell recovery
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Stroke: the dashed hopes of neuroprotection
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Plate reader-based cell viability assays for glioprotection using primary rat optic nerve head astrocytes
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Introducing Harry A. Quigley, the 2004 Recipient of the Friedenwald Award
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Establishment of the ocular hypertension model using the common marmoset
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Translational Pharmacology in Glaucoma Neuroprotection
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Astrocytes and glaucomatous neurodegeneration
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Authors: Almasieh, M., & Levin, L. A.
Affiliations: Hôpital Maisonneuve-Rosemont (CA)
University of Wisconsin–Madison (US)
Corresponding author: Levin, Leonard A.
ORCID: Almasieh, Mohammadali
Levin, Leonard A.
Venue: Annual Review of Vision Science
Publisher: Annual Reviews
Published: 2017-09-15
Volume: 3
Issue: 1
Pages: 91-120
ISSN: 2374-4642 (ISSN-L)
2374-4650
DOI: 10.1146/annurev-vision-102016-061422
OpenAlex: W2732996930
Cited by: 111
References: 185
Citations by year: 2026: 7 · 2025: 10 · 2024: 8 · 2023: 19 · 2022: 19 · 2021: 13 · 2020: 18 · 2019: 12 · 2018: 3 · 2017: 2
FWCI: 1.77
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Vision Science (publishedVersion)
PubMed (publishedVersion)
Funders: Research to Prevent Blindness
Canada Research Chairs
National Institutes of Health
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: glaucoma, neuroprotection, retinal ganglion cells, optic neuropathy, glaucoma animal model, neuroprotective therapy, intraocular pressure, retinal ganglion cell death, visual field defects
MeSH terms: Neuroprotection, Animals, Disease Models, Animal, Glaucoma, Humans, Optic Nerve Diseases, Neuroprotective Agents, Neurodegenerative Diseases, Laser Therapy, Translational Research, Biomedical

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Neuroprotection in Glaucoma: Animal Models and Clinical Trials

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