Neuroprotection in Glaucoma: Animal Models and Clinical Trials

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Reduction of Intraocular Pressure and Glaucoma Progression

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Oxidative stress in the eye and its role in the pathophysiology of ocular diseases

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Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

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Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

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Prevalence of Primary Angle Closure Glaucoma in the Last 20 Years: A Meta-Analysis and Systematic Review

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Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

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Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma

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Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

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Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments

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Retinal Neurodegeneration as an Early Manifestation of Diabetic Eye Disease and Potential Neuroprotective Therapies

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Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

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Therapeutic Drugs and Devices for Tackling Ocular Hypertension and Glaucoma, and Need for Neuroprotection and Cytoprotective Therapies

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Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art

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Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

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Translational Preclinical Pharmacologic Disease Models for Ophthalmic Drug Development

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Experimental Models of Glaucoma: A Powerful Translational Tool for the Future Development of New Therapies for Glaucoma in Humans—A Review of the Literature

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Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4

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Can Treatment With Citicoline Eyedrops Reduce Progression in Glaucoma? The Results of a Randomized Placebo-controlled Clinical Trial

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Glaucoma After Corneal Trauma or Surgery—A Rapid, Inflammatory, IOP-Independent Pathway

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Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress

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Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology

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Microglial cGAS–STING signaling underlies glaucoma pathogenesis

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Focused Update on AAV-Based Gene Therapy Clinical Trials for Inherited Retinal Degeneration

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Protective effect of the natural flavonoid naringenin in mouse models of retinal injury

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i Drugs and i Devices Discovery Research: Preclinical Assays, Techniques, and Animal Model Studies for Ocular Hypotensives and Neuroprotectants

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Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering

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Circular RNA-based therapy provides sustained and robust neuroprotection for retinal ganglion cells

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Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial

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Neuroprotective effect of mesenchymal stem cell-derived extracellular vesicles on optic nerve injury in chronic ocular hypertension

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A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations

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Treatment choices for newly diagnosed primary open angle and ocular hypertension patients

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Retinal Cell Protection in Ocular Excitotoxicity Diseases. Possible Alternatives Offered by Microparticulate Drug Delivery Systems and Future Prospects

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Molecular Targets Involved in the Neuroprotection Mediated by Terpenoids

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Nanoparticles for the treatment of glaucoma-associated neuroinflammation

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Bio-tactics for neuroprotection of retinal ganglion cells in the treatment of glaucoma

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Neuroprotection: A versatile approach to combat glaucoma

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Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects

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The neuroprotective effects of novel estrogen receptor GPER1 in mouse retinal ganglion cell degeneration

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Optogenetic Stimulation of the Superior Colliculus Confers Retinal Neuroprotection in a Mouse Glaucoma Model

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C3 Transferase-Expressing scAAV2 Transduces Ocular Anterior Segment Tissues and Lowers Intraocular Pressure in Mouse and Monkey

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The Role of MicroRNAs in Mitochondria-Mediated Eye Diseases

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Retinal Neuroprotection: Overcoming the Translational Roadblocks

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Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies

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Glaucoma: neuroprotection with NAD-based therapeutic interventions

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New perspectives of immunomodulation and neuroprotection in glaucoma

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Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma

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Role of mammalian target of rapamycin in regulating HIF-1α and vascular endothelial growth factor signals in glaucoma

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Mutation-independent therapies for retinal diseases: focus on gene-based approaches

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Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals

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Molecular changes in glaucomatous trabecular meshwork. Correlations with retinal ganglion cell death and novel strategies for neuroprotection

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A Robust Microbead Occlusion Model of Glaucoma for the Common Marmoset

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Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation

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Organotypic cultures as aging associated disease models

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A Deep Learning Approach to Improve Retinal Structural Predictions and Aid Glaucoma Neuroprotective Clinical Trial Design

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Using Noninvasive Electrophysiology to Determine Time Windows of Neuroprotection in Optic Neuropathies

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The Prevalence Trend of Glaucoma by Age and Sex Difference in South Asia: A Systematic Review and Meta‐Analysis of Population‐Based Studies

Banik, S., Ghosh, A., & Debi, H. (2025) · Health Science Reports · doi:10.1002/hsr2.70542 · Cited by 10

Neuroprotection in glaucoma‑electrophysiology (Review)

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The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model

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Neuronal p58IPK Protects Retinal Ganglion Cells Independently of Macrophage/Microglia Activation in Ocular Hypertension

McLaughlin, T., Wang, J., Jia, L., Wu, F., Wang, Y., Wang, J. J., Mu, X., & Zhang, S. X. (2023) · Cells · doi:10.3390/cells12121558 · Cited by 8

Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma

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Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism

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Neuroprotective Strategies in Glaucoma - Translation to Clinical Trials

Fang, C. E. H., Guo, L., Hill, D., Yap, T. E., & Cordeiro, M. F. (2020) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2002062 · Cited by 9

Biomechanical Properties of the Sclera

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Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies

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Formulation and evaluation of polymer-coated bimatoprost-chitosan matrix ocular inserts for sustained lowering of IOP in rabbits

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The Anti-Inflammatory and Antioxidant Properties of Acebuche Oil Exert a Retinoprotective Effect in a Murine Model of High-Tension Glaucoma

Lucchesi, M., Marracci, S., Amato, R., Lapi, D., Garrido, Á. S., Espinosa‐Martín, P., Vázquez, C. M., Mate, A., & Monte, M. D. (2024) · Nutrients · doi:10.3390/nu16030409 · Cited by 7

Neuroprotection of the Inner Retina Also Prevents Secondary Outer Retinal Pathology in a Mouse Model of Glaucoma

Kumar, S., Ramakrishnan, H., Viswanáthan, S., Akopian, A., & Bloomfield, S. A. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.9.35 · Cited by 7

Targeted Delivery of Mitochondrial Calcium Channel Regulators: The Future of Glaucoma Treatment?

Cheung, L. T. Y., Manthey, A. L., Lai, J. S. M., & Chiu, K. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00648 · Cited by 7

Neuroprotection in Glaucoma

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Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model

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Fluoxetine Protects Retinal Ischemic Damage in Mice

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Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma

Sato, K., Takada, N., Fujioka, A., Himori, N., Yokoyama, Y., Tsuda, S., Omodaka, K., Kirihara, T., Ishikawa, M., Kunikata, H., et al. (2023) · Journal of Glaucoma · doi:10.1097/ijg.0000000000002257 · Cited by 7

Role of APOE in glaucoma

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Sustained Neurotrophic Factor Co-Treatment Enhances Donor and Host Retinal Ganglion Cell Survival in Mice

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Refractive adaptive optics scanning light ophthalmoscope with fast 2D MEMS scanner

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AAV-IKV mediated expression of decorin inhibits EMT and fibrosis in a murine model of Glaucoma and AAV-IKV transduction in Non-Human Primates

Rao, P., Mishra, M., Cashman, S. M., Walton, D. S., & Kumar‐Singh, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-92273-5 · Cited by 4

Statistical Analysis on Time to Blindness of Glaucoma Patients at Jimma University Specialized Hospital: Application of Accelerated Failure Time Model

Bambo, M. M., & Gebremariam, M. G. (2022) · Journal of Ophthalmology · doi:10.1155/2022/9145921 · Cited by 4

The Impact of Hindlimb Suspension on the Rat Eye: A Molecular and Histological Analysis of the Retina

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Oxidative Stress in Glaucoma: From Pathogenic Mechanisms to Emerging Antioxidant Therapies

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Artificial intelligence and neural networks in the diagnosis of glaucoma

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Primāras atvērta kakta glaukomas ķirurģiskās ārstēšanas ietekme uz redzes nerva strukturālajiem un funkcionālajiem rādītājiem un saistība ar ātrija nātrijurētiskā peptīda līmeni. Promocijas darbs

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Various forms of glaucoma and their treatments

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